Areca nut extracts-activated secretion of leukotriene B4, and phosphorylation of p38 mitogen-activated protein kinase and elevated intracellular calcium concentrations in human polymorphonuclear leukocytes

Journal of Periodontal Research

Volumn 42, Issue 5, 2007, Pages 393-401

  Hung, S L ^a   Lin, Y J ^a   Chien, E J ^a   Liu, W G ^a   Chang, H W ^a   Liu, T Y ^b   Chen, Y T ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Areca nut; Calcium; Leukotriene B4; p38 mitogen activated protein kinase; Polymorphonuclear leukocyte

Indexed keywords

1,2 BIS(2 AMINOPHENOXY)ETHANE N,N,N',N' TETRAACETIC ACID ACETOXYMETHYL ESTER; 1,2-BIS(2-AMINOPHENOXY)ETHANE N,N,N',N'-TETRAACETIC ACID ACETOXYMETHYL ESTER; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AUTACOID; CHELATING AGENT; DRUG DERIVATIVE; EGTAZIC ACID; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; LEUKOTRIENE B4; MITOGEN ACTIVATED PROTEIN KINASE P38; PLANT EXTRACT; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BETEL NUT; CALCIUM SIGNALING; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYME IMMUNOASSAY; FLUOROMETRY; HUMAN; IMMUNOBLOTTING; METABOLISM; NEUTROPHIL; PHOSPHORYLATION; SECRETION; TIME;

ARECA; CALCIUM SIGNALING; CHELATING AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EGTAZIC ACID; ENZYME INHIBITORS; FLUOROMETRY; HUMANS; IMIDAZOLES; IMMUNOBLOTTING; IMMUNOENZYME TECHNIQUES; INFLAMMATION MEDIATORS; LEUKOTRIENE B4; NEUTROPHILS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLANT EXTRACTS; PYRIDINES; TIME FACTORS;

EID: 34548209653     PISSN: 00223484     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2006.00958.x     Document Type: Article

References (54)

1. Jeng JH, Chang MC, Hahn LJ. Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives. Oral Oncol 2001 37 : 477 492.
2. Mehta FS, Sanjana MK, Barretto MA, Doctor R. Relation of betel leaf chewing to periodontal disease. J Am Dent Assoc 1955 50 : 531 536.
3. Waerhaug J. Prevalence of periodontal disease in Ceylon. Association with age, sex, oral hygiene, socioeconomic factors, vitamin deficiencies, malnutrition, betel and tobacco consumption and ethnic group. Final report. Acta Odontol Scand 1967 25 : 205 231.
4. Ling L-J, Hung S-L, Tseng S-C et al. Association between betel quid chewing, periodontal status and periodontal pathogens. Oral Microbiol Immunol 2001 16 : 364 369.
5. Amarasena N, Ekanayaka AN, Herath L, Miyazaki H. Association between smoking, betel chewing and gingival bleeding in rural Sri Lanka. J Clin Periodontol 2003 30 : 403 408.
6. Chang MC, Kuo MY, Hahn LJ, Hsieh CC, Lin SK, Jeng JH. Areca nut extract inhibits the growth, attachment, and matrix protein synthesis of cultured human gingival fibroblasts. J Periodontol 1998 69 : 1092 1097.
7. Jeng JH, Ho YS, Chan CP et al. Areca nut extract up-regulates prostaglandin production, cyclooxygenase-2 mRNA and protein expression of human oral keratinocytes. Carcinogenesis 2000 21 : 1365 1370.
8. 2, interleukin-6 and TNF-alpha production of oral epithelial cells by areca nut extract and arecoline. Carcinogenesis 2003 24 : 1301 1315.
9. Ling L-J, Ho F-C, Chen Y-T, Holborow D, Liu T-Y, Hung S-L. Areca nut extracts modulated expression of alkaline phosphatase and receptor activator of nuclear factor KB ligand in osteoblasts. J Clin Periodontol 2005 32 : 353 359.
10. Miyasaki KT, Wilson ME, Brunetti AD, Genco RJ. Oxidative and nonoxidative killing of Actinobacillus actinomycetemcomitans by human neutrophils. Infect Immun 1986 53 : 154 160.
11. Miyasaki KT. The neutrophil: mechanisms of controlling periodontal bacteria. J Periodontol 1991 62 : 761 774.
12. Delima AJ, Van Dyke TE. Origin and function of the cellular components in gingival crevice fluid. Periodontol 2000 2003 31 : 55 76.
13. Anderson DC, Schmalsteig FC, Finegold MJ et al. The severe and moderate phenotypes of heritable Mac-1, LFA-1 deficiency: their quantitative definition and relation to leukocyte dysfunction and clinical features. J Infect Dis 1985 152 : 668 689.
14. Seymour GJ. Possible mechanisms involved in the immunoregulation of chronic inflammatory periodontal disease. J Dent Res 1987 66 : 2 9.
15. De Beule F, Bercy P, Ferrant A. The effectiveness of a preventive regimen on the periodontal health of patients undergoing chemotherapy for leukemia and lymphoma. J Clin Periodontol 1991 18 : 346 347.
16. Hart TC, Shapira L, Van Dyke TE. Neutrophil defects as risk factors for periodontal diseases. J Periodontol 1994 65 : 521 529.
17. Hung S-L, Chen Y-L, Wan H-C, Liu T-Y, Chen Y-T, Ling L-J. Effects of areca nut extracts on the functions of human neutrophils in vitro. J Periodont Res 2000 35 : 186 193.
18. Hung S-L, Cheng Y-Y, Peng J-L, Chang L-Y, Liu T-Y, Chen Y-T. Inhibitory effects of areca nut extracts on phagocytosis of Actinobacillus actinomycetemcomitans ATCC 33384 by neutrophils. J Periodontol 2005 76 : 373 379.
19. Hung S-L, Lee Y-Y, Liu T-Y, Peng J-L, Cheng Y-Y, Chen Y-T. Modulation of phagocytosis, chemotaxis, and adhesion of neutrophils by areca nut extracts. J Periodontol 2006 77 : 579 585.
20. Lai Y-L, Lin J-C, Yang S-F, Liu T-Y, Hung S-L. Areca nut extracts reduced the intracellular reactive oxygen species and release of myeloperoxidase by human polymorphonuclear leukocytes. J Periodont Res 2007 (in press).
21. Denzlinger C. Biology and pathophysiology of leukotrienes. Crit Rev Oncol Hematol 1996 23 : 167 223.
22. Hammarberg T, Radmark O. 5-Lipoxygenase binds calcium. Biochemistry 1999 38 : 4441 4447.
23. Hammarberg T, Provost P, Persson B, Radmark O. The N-terminal domain of 5-lipoxygenase binds calcium and mediates calcium stimulation of enzyme activity. J Biol Chem 2000 275 : 38787 38793.
24. Werz O, Burkert E, Samuelsson B, Radmark O, Steinhilber D. Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes. Blood 2002 99 : 1044 1052.
25. Werz O, Burkert E, Fischer L et al. Extracellular signal-regulated kinases phosphorylate 5-lipoxygenase and stimulate 5-lipoxygenase product formation in leukocytes. FASEB J 2002 16 : 1441 1443.
26. Samuelsson B, Dahlen SE, Lindgren JA, Rouzer CA, Serhan CN. Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science 1987 237 : 1171 1176.
27. 4 in inflammation. Crit Rev Immunol 1990 10 : 1 12.
28. 4-induced permeability increase in postcapillary venules and its inhibition by three different antiinflammatory drugs. Inflammation 1989 13 : 693 705.
29. 2 and tumour necrosis factor alpha in experimental gingivitis in humans. J Periodont Res 1993 28 : 241 247.
30. 4 in gingival crevicular fluid and gingival tissue in specific periodontal diseases. J Periodontol 2001 72 : 1025 1031.
31. Baroukh B, Saffar JS. The effect of leukotriene synthesis inhibitors on hamster periodontitis. Arch Oral Biol 1990 35 : 189S 192S.
32. Liu TY, Chen CL, Chi CW. Oxidative damage to DNA induced by areca nut extract. Mutat Res 1996 367 : 25 31.
33. Bhakdi S, Greulich S, Muhly M et al. Potent leukocidal action of Escherichia coli hemolysin mediated by permeabilization of target cell membranes. J Exp Med 1989 169 : 737 754.
34. Lakhanpal S, Gonchoroff NJ, Katzmann JA, Handwerger BS. A flow cytofluorometric double staining technique for simultaneous determination of human mononuclear cell surface phenotype and cell cycle phase. J Immunol Methods 1987 96 : 35 40.
35. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985 260 : 3440 3450.
36. Kuehl FA Jr., Egan RW. Prostaglandins, arachidonic acid, and inflammation. Science 1980 210 : 978 984.
37. Lewis RA, Austen KF, Soberman RJ. Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases. N Engl J Med 1990 323 : 645 655.
38. Werz O, Steinhilber D. Development of 5-lipoxygenase inhibitors - lessons from cellular enzyme regulation. Biochem Pharmacol 2005 70 : 327 333.
39. 4 stimulates polymorphonuclear leukocyte adhesion to cultured vascular endothelial cells. J Clin Invest 1984 74 : 1552 1555.
40. 4 stimulates osteoclastic bone resorption both in vitro and in vivo. J Bone Miner Res 1996 11 : 1619 1627.
41. Traianedes K, Dallas MR, Garrett IR, Mundy GR, Bonewald LF. 5-Lipoxygenase metabolites inhibit bone formation in vitro. Endocrinology 1998 139 : 3178 3184.
42. Weissmann G, Smolen JE, Korchak HM. Release of inflammatory mediators from stimulated neutrophils. N Engl J Med 1980 303 : 27 34.
43. Korchak HM, Vienne K, Rutherford LE, Wilkenfeld C, Finkelstein MC, Weissmann G. Stimulus response coupling in the human neutrophil. II. Temporal analysis of changes in cytosolic calcium and calcium efflux. J Biol Chem 1984 259 : 4076 4082.
44. Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 1992 258 : 607 614.
45. Lee MJ, Hsu JD, Lin CL, Lin MH, Yuan SC, Wang CJ. Induction of epidermal proliferation and expressions of PKC and NF-kappaB by betel quid extracts in mouse: the role of lime-piper additives in betel quid. Chem Biol Interact 2002 140 : 35 48.
46. Koivunen J, Aaltonen V, Peltonen J. Protein kinase C (PKC) family in cancer progression. Cancer Lett 2006 8 : 1 10.
47. Lin SC, Lu SY, Lee SY, Lin CY, Chen CH, Chang KW. Areca (betel) nut extract activates mitogen-activated protein kinases and NF-kappaB in oral keratinocytes. Int J Cancer 2005 116 : 526 535.
48. Yang SC, Lin SC, Chiang WF, Yen CY, Lin CH, Liu SY. Areca nut extract treatment elicits the fibroblastoid morphological changes, actin re-organization and signaling activation in oral keratinocytes. J Oral Pathol Med 2003 32 : 600 605.
49. Eberhard J, Jepsen S, Pohl L, Albers HK, Acil Y. Bacterial challenge stimulates formation of arachidonic acid metabolites by human keratinocytes and neutrophils in vitro. Clin Diagn Lab Immunol 2002 9 : 132 137.
50. 4 is measurable in serum of smokers and nonsmokers. Clin Chem 1989 35 : 459 460.
51. 4 by rat alveolar macrophages. Respiration 1989 56 : 198 203.
52. Saareks V, Riutta A, Mucha I, Alanko J, Vapaatalo H. Nicotine and cotinine modulate eicosanoid production in human leukocytes and platelet rich plasma. Eur J Pharmacol 1993 248 : 345 349.
53. Nilsson E, Edenius C, Lindgren JA. Ethanol affects leukotriene generation and leukotriene-induced functional responses in human polymorphonuclear granulocytes. Scand J Clin Lab Invest 1995 55 : 589 596.
54. Ko YC, Chiang TA, Chang SJ, Hsieh SF. Prevalence of betel quid chewing habit in Taiwan and related sociodemographic factors. J Oral Pathol Med 1992 21 : 261 264.