The existence of multiple conformers of interleukin-21 directs engineering of a superpotent analogue

Journal of Biological Chemistry

Volumn 282, Issue 32, 2007, Pages 23326-23336

  Bondensgaard, Kent ^a   Breinholt, Jens ^a   Madsen, Dennis ^a   Omkvist, Diana Højmark ^a   Kang, Lishan ^b   Worsaae, Anne ^a   Becker, Peter ^a   Schiødt, Christine Bruun ^a   Hjorth, Siv A ^a  

^a NOVO NORDISK A S   (Denmark)

^b SIBS Novo Nordisk Translational Research Centre for PreDiabetes   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS;

CELLULAR ASSAY; CYTOKINES; HUMAN INTERLEUKIN (HIL)-21; RECEPTOR BINDING;

CONFORMATIONS;

INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 4;

ANIMAL CELL; ARTICLE; CELL ASSAY; CONTROLLED STUDY; HUMAN; HUMAN CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RECEPTOR BINDING;

AMINO ACID SEQUENCE; CELL LINE; CRYSTALLOGRAPHY, X-RAY; HUMANS; INTERLEUKINS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; TEMPERATURE;

EID: 34548185676     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M701313200     Document Type: Article

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