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Volumn 13, Issue 10, 2007, Pages 1099-1108
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CoMFA study of distamycin analogs binding to the minor-groove of DNA: A unified model for broad-spectrum activity
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Author keywords
3D QSAR; Broad spectrum antibacterials; Distamycin analogs; DNA minor groove binders; Drug resistant bacterial strains (MRSA, VSEF, PRSP); Unified CoMFA model
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Indexed keywords
BACTERIAL DNA;
DISTAMYCIN A DERIVATIVE;
METICILLIN;
PENICILLIN G;
VANCOMYCIN;
ANTIBACTERIAL ACTIVITY;
ANTIBIOTIC RESISTANCE;
ANTIMICROBIAL ACTIVITY;
ARTICLE;
COMPARATIVE MOLECULAR FIELD ANALYSIS;
CONTROLLED STUDY;
DRUG DESIGN;
DRUG DNA BINDING;
DRUG STRUCTURE;
ENTEROCOCCUS FAECALIS;
METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;
MINIMUM INHIBITORY CONCENTRATION;
MOLECULAR MODEL;
NONHUMAN;
PENICILLIN RESISTANCE;
PRIORITY JOURNAL;
QUANTITATIVE STRUCTURE ACTIVITY RELATION;
STATISTICAL SIGNIFICANCE;
STEREOSPECIFICITY;
STREPTOCOCCUS PNEUMONIAE;
STRUCTURE ACTIVITY RELATION;
THREE DIMENSIONAL IMAGING;
ANTIVIRAL AGENTS;
CHEMISTRY, PHARMACEUTICAL;
COMPUTER SIMULATION;
DISTAMYCINS;
DNA;
DRUG DESIGN;
ELECTROSTATICS;
MODELS, CHEMICAL;
MODELS, MOLECULAR;
MODELS, THEORETICAL;
MOLECULAR CONFORMATION;
QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;
SOFTWARE;
BACTERIA (MICROORGANISMS);
METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;
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EID: 34548147317
PISSN: 16102940
EISSN: 09485023
Source Type: Journal
DOI: 10.1007/s00894-007-0234-3 Document Type: Article |
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Times cited : (6)
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References (14)
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