Quantitation of five nevirapine oxidative metabolites in human plasma using liquid chromatography-tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 856, Issue 1-2, 2007, Pages 252-260

  Rowland, Lois S ^a   MacGregor, Thomas R ^a   Campbell, Scot J ^a   Jenkins, Rand ^b   Pearsall, Amy B ^b   Morris, Jennifer P ^b  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b Pharmaceutical Product Development   (United States)

Author keywords

12 Hydroxynevirapine; 2 Hydroxynevirapine; 3 Hydroxynevirapine; 4 Carboxynevirapine; 8 Hydroxynevirapine; Nevirapine metabolites

Indexed keywords

12-HYDROXYNEVIRAPINE; 2-HYDROXYNEVIRAPINE; 3-HYDROXYNEVIRAPINE; 4-CARBOXYNEVIRAPINE; 8-HYDROXYNEVIRAPINE; NEVIRAPINE METABOLITES;

ACETONITRILE; BIOASSAY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRECIPITATION (CHEMICAL); PROTEINS;

METABOLITES;

12 HYDROXYNEVIRAPINE; 2 HYDROXYNEVIRAPINE; 3 HYDROXYNEVIRAPINE; 4 CARBOXYNEVIRAPINE; 8 HYDROXYNEVIRAPINE; ACETONITRILE; DRUG METABOLITE; GLUCURONIDE; NEVIRAPINE; PIRENZEPINE; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ARTICLE; ASSAY; BLOOD SAMPLING; CONCENTRATION RESPONSE; DRUG BLOOD LEVEL; DRUG CONJUGATION; DRUG ISOLATION; DRUG MONITORING; FREEZE THAWING; HEPARINIZATION; HUMAN; HYDROLYSIS; LIQUID CHROMATOGRAPHY; LIVER DYSFUNCTION; METABOLITE; OXIDATION; PRECIPITATION; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; ROOM TEMPERATURE; STANDARD; STEADY STATE; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

CALIBRATION; HUMANS; NEVIRAPINE; OXIDATION-REDUCTION; QUALITY CONTROL; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE INHIBITORS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 34548137272     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.06.007     Document Type: Article

References (33)

1. Merluzzi V.J., Hargrave K.D., Labadia M., Grozinger K., Skoog M., Wu J.C., Shih C.-K., Eckner K., Hattox S., Adams J., Rosenthal A.S., Faanes R., Eckner R.J., Koup R.A., and Sullivan J.L. Science 250 (1990) 1411
2. Wu J.C., Warren T.C., Adams J., Proudfoot J., Skiles J., Raghavan P., Perry C., Potocki I., Farina P.R., and Grob P.M. Biochemistry 30 (1991) 2022
3. Lamson M.J., Sabo J.P., MacGregor T.R., Pav J.W., Rowland L., Hawi A., Cappola M., and Robinson P. Biopharm. Drug Dispos. 20 (1999) 285
4. Riska P., Lamson M., MacGregor T., Sabo J., Hattox S., Pav J., and Keirns J. Drug Metab. Dispos. 27 (1999) 895
5. Lamson M., MacGregor T., Riska P., Erickson D., Maxfield P., Rowland L., Gigliotti M., Robinson P., Azzam S., and Keirns J. Clin. Pharmacol. Ther. 65 (1999) 137
6. Grozinger K.G., Byrne D.P., Nummy L.J., and Ridges M.D. J. Heterocyclic Chem. 37 (2000) 229
7. Kappelhoff B.S., vanLeth F., MacGregor T.R., Lange J.M.A., Beijnen J.H., and Huitema A.D.R. Antiviral Ther. 10 (2005) 145
8. Kappelhoff B.S., van Leth F., Robinson P.A., MacGregor T.R., Baraldi F., Montella F., Uip D.E., Thompson M.A., Russell D.B., Lange J.M.A., Beijnen J.H., and Huitema A.D.R. Antiviral Ther. 10 (2005) 489
9. Kappelhoff B.S., Huitema A.D.R., van Leth F., Robinson P.A., MacGregor T.R., Lange J.M.A., and Beijnen J.H. HIV Clin. Trials 6 (2005) 254
10. van Heeswijk R.P.G., Hoetelmans R.M.W., Meenhorst P.L., Mulder J.W., and Beijnen J.H. J. Chromatogr. B 713 (1998) 395
11. Pav J.W., Rowland L.S., and Korpalski D.J. J. Pharm. Biomed. Anal. 20 (1999) 91
12. Hollanders R.M.F., van Ewijk-Beneken Kolmer E.W.J., Burger D.M., Wuis E.W., Koopmans P.P., and Hekster Y.A. J. Chromatogr. B 744 (2000) 65
13. Aymard G., Legrand M., Trichereau N., and Diquet B. J. Chromatogr. B 744 (2000) 227
14. Dailly E., Thomas L., Kergueris M.F., Jolliet P., and Bourin M. J. Chromatogr. B 758 (2001) 129
15. Lopez R.M., Pou L., Gomez M.R., Ruiz I., and Monterde J. J. Chromatogr. B 751 (2001) 371
16. Marzolini C., Beguin A., Telenti A., Schreyer A., Buelin T., Biollaz J., and Decosterd L.A. J. Chromatogr. B 774 (2002) 127
17. Fan B., and Stewart J.T. J. Pharm. Biomed. Anal. 28 (2002) 903
18. Poirier J.-M., Robidou P., and Jaillon P. Ther. Drug Monit. 24 (2002) 302
19. Tribut O., Arvieux C., Michelet C., Chapplain J.-M., Allain H., and Bentue-Ferrer D. Ther. Drug Monit. 24 (2002) 554
20. Droste J.A.H., Verweij-van Wissen C.P.W.G.M., and Burger D.M. Ther. Drug Monit. 25 (2003) 393
21. Rezk N.L., Tidwell R.R., and Kashuba A.D.M. J. Chromatogr. B 791 (2003) 137
22. Kappelhoff B.S., Rosing H., Huitema A.D.R., and Beijnen J.H. J. Chromatogr. B 792 (2003) 353
23. Rezk N.L., Tidwell R.R., and Kashuba A.D.M. J. Chromatogr. B 805 (2004) 241
24. Silverthorn C.F., and Parsons T.L. Biomed. Chromatogr. 20 (2006) 23
25. Ramachandran G., Hemanthkumar A.K., Kumaraswami V., and Swaminathan S. J. Chromatogr. B 843 (2006) 339
26. Langmann P., Schirmer D., Vath T., Desch S., Zilly M., and Klinker H. J. Chromatogr. B 767 (2002) 69
27. Fan B., and Stewart J.T. J. Pharm. Biomed. Anal. 30 (2002) 955
28. Dubuisson J.G., King J.R., Stringer J.S.A., Turner M.L., Bennetto C., and Acosta E.P. J. Acquir. Immune Defic. Syndr. 35 (2004) 155
29. Chi B.H., Lee A., Acosta E.P., Westerman L.E., Sinkala M., and Stringer J.S.A. HIV Clin. Trials 7 (2006) 263
30. Villani P., Feroggio M., Gianelli L., Bartoli A., Montagna M., Maserati R., and Regazzi M.B. Ther. Drug Monit. 23 (2001) 380
31. Chi J., Jayewardene A.L., Stone J.A., and Aweeka F.T. J. Pharm. Biomed. Anal. 31 (2003) 953
32. Azoulay S., Nevers M.-C., Creminon C., Heripret L., Durant J., Dellamonica P., Grassi J., Guedj R., and Duval D. Antimicrob. Agents Chemother. 48 (2004) 104
33. Homon C.A., Esber H.J., Zavorskas P., Tanswell P., and Farina P.R. Ther. Drug Monit. 9 (1987) 236