Effect of ABCB1 (MDR1) 3435C>T, and 2677G>A,T polymorphisms and P-glycoprotein inhibitors on salivary digoxin secretion in congestive heart failure patients

Pharmacological Reports

Volumn 59, Issue 3, 2007, Pages 323-329

  Bartnicka, Lilianna ^a   Kurzawski, Mateusz ^a   Drozdzik, Agnieszka ^a   Plonska Gosciniak, Edyta ^a   Gornik, Wanda ^a   Drozdzik, Marek ^a  

^a POMERANIAN MEDICAL UNIVERSITY   (Poland)

Author keywords

ABCB1 polymorphism; Digoxin; P glycoprotein; Salivary secretion

Indexed keywords

ADENINE; AMIODARONE; ATORVASTATIN; CARVEDILOL; CYTOSINE; DIGOXIN; FAMOTIDINE; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; GUANINE; MULTIDRUG RESISTANCE PROTEIN 1; PREDNISONE; PROPAFENONE; SIMVASTATIN; SPIRONOLACTONE; TYROSINE; VERAPAMIL;

ADULT; AGED; AMINO ACID SUBSTITUTION; ARTICLE; COMBINATION CHEMOTHERAPY; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG SALIVA LEVEL; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SALIVATION; STEADY STATE;

EID: 34548128779     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Becquemont L, Verstuyft C, Kerb R, Brinkmann U, Lebot M, Jaillon P, Funck-Brentano C: Effect of grapefruit juice on digoxin pharmacokinetics in humans. Clin Pharmacol Ther, 2001, 70, 311-316.
2. Drozdzik M, Mysliwiec K, Lewinska-Cheustowska M, Banach J, Drozdzik A, Grabarek J: P-glycoprotein drug transporter MDR1 gene polymorphism in renal transplant patients with and without gingival overgrowth. J Clin Periodontol, 2004, 31, 758-763.
3. Gerloff T, Schaefer M, Johne A, Oselin K, Meisel C, Cascorbi I, Roots I: MDR1 genotypes do not discriminate between absorptive pharmacokinetic parameters of a single oral dose of 1 mg digoxin in healthy white volunteers. Br J Clin Pharmacol, 2002, 54, 661-616.
4. Gustincich S, Manfioletti G, Del Sal G, Schneider C, Carninci P: A fast method for high-quality genomic DNA extraction from whole human blood. Biotechniques, 1991, 11, 298-300.
5. Haeckel R, Hanecke P: Application of saliva for drug monitoring an in vitro model for transmembrane transport. Eur J Clin Chem Clin Biochem, 1996, 34, 171-191.
6. Haeckel R, Muhlenfeld HM: Reasons-for intraindividual inconstancy of the digoxin saliva to serum concentration ratio. J Clin Chem Clin Biochem, 1989, 27, 653-658.
7. Hoffmeyer S, Burk O, von Richter O, Arnold BP, Brockmoller J, Johne A, Cascorbi I et al.: Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA, 2000, 97, 3473-3478.
8. Johne A, Kopke K, Gerloff T, Mai I, Rietbrock S, Meisel C, Hoffmeyer S et al.: Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene. Clin Pharmacol Ther, 2002, 72, 584-594.
9. Jusko WJ, Gerbracht L, Golden LH, Koup JR: Digoxin concentrations in serum and saliva. Res Commun Chem Pathol Pharmacol, 1975, 17, 310-312.
10. Kurata Y, Ieiri I. Kimura M, Morita M, Irie S, Urae A, Ohdo S et al.: Role of human MDR1 gene polymorphism in bioavailability and interpretation of digoxin, a substrate of P-glycoprotein. Clin Pharmacol Ther, 2002, 72, 209-219.
11. Kurzawski M, Pawlik A, Górnik W, Droździk M: Frequency of common MDR1 gene variants in a Polish population. Pharmacol Rep, 2006, 58, 35-40.
12. Liu H, Delgado RD: Therapeutic drug concentration monitoring using saliva samples. Clin Pharmacokinet, 1999, 36, 453-470.
13. Marzolini C, Paus E, Buclin T, Kim R: Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin Pharmacol Ther, 2004, 75, 13-33.
14. Sakaeda T: MDR1 genotype-related pharmacokinetics: fact or fiction? Drug Metab Pharmacokinet, 2005, 20, 391-414.
15. Seymour RA, Thomason JM, Ellis JS: The pathogenesis of drug-induced gingival overgrowth. J Clin Periodontol, 1996, 23, 165-175.
16. Tanabe M, Ieiri I, Nagata N, Inoue K, Ito S, Kanamori Y, Takahashi M et al.: Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene. J Pharmacol Exp Ther, 2001, 297, 1137-1143.
17. Uematsu T, Yamaoka M, Doto F, Tanaka H, Matsuura T, Furusawa K: Expression of ATP-binding cassette transporter in human salivary ducts. Arch Oral Biol, 2003, 48, 87-90.
18. Wang D, Johnson AD, Papp AC, Kroetz DL, Sadee W: Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability. Pharmacogenetics Genomics, 2005, 15, 693-704.