Xylitol intoxication associated with fulminant hepatic failure in a dog

Journal of Veterinary Emergency and Critical Care

Volumn 17, Issue 3, 2007, Pages 286-289

  Todd, Jeffrey M ^a   Powell, Lisa L ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Artificial sweetener; Liver failure; SAMe

Indexed keywords

CANIS FAMILIARIS;

EID: 34548128353     PISSN: 14793261     EISSN: 14764431     Source Type: Journal    
DOI: 10.1111/j.1476-4431.2007.00243.x     Document Type: Article

References (16)

1. Peldyak J, Makinen KK. Xylitol for caries prevention. J Dent Hyg 2002 76 (4) : 276 285.
2. Kuzuya T, Kanazawa Y, Kosaka K. Stimulation of insulin secretion by xylitol in dogs. Endocrinology 1969 84 (2) : 200 207.
3. Wilson RB, Martin JM. Plasma insulin concentrations in dogs and monkeys after xylitol, glucose or tolbutamide infusion. Diabetes 1970 19 (1) : 17 22.
4. Kuzuya T, Kanazawa Y, Kosaka K. Plasma insulin response to intravenously administered xylitol in dogs. Metabolism 1966 15 (12) : 1149 1152.
5. Dunayer EK, Gwaltney-Brand SM. Acute hepatic failure and coagulopathy associated with xylitol ingestion in eight dogs. J Am Vet Med Assoc 2006 229 (7) : 1113 1117.
6. Asano T, Greenberg BZ, Wittmers R, et al. Xylitol, a partial homologue of α-d-glucopyranose: potent stimulator of insulin release in dogs. Endocrinology 1977 100 (2) : 339 345.
7. Kitchens DH. Xylitol in the prevention of oral diseases. Spec Care Dentist 2005 25 (3) : 140 144.
8. Korttila K, Mattila MAK. Increased serum concentrations of lactic, pyruvic and uric acid and bilibubin after postoperative xylitol infusion. Acta Anaesthesiol Scan 1979 23 (3) : 273 277.
9. Dunayer EK. Hypoglycemia following canine ingestion of xylitol-containing gum. Veter Hum Toxicol 2004 46 (2) : 87 88.
10. Khalid Q, Rahman MA. Studies on xylitol-induced insulin secretion in vitro. Biomed Pharmacother 1984 38 (3) : 175 178.
11. Cope RB. A screening study of xylitol binding in vitro to activated charcoal. Veter Hum Toxicol 2004 46 (6) : 336 337.
12. Rothuizen J. General principles in the treatment of liver disease, In : Ettinger SJ, Feldman EC. eds. Textbook of Veterinary Internal Medicine, 6th edn. Philadephia, PA : WB Saunders Co. 2005, pp. 1436 1437.
13. Terneus MV, Kiningham KK, Carpenter AB, et al. Comparison of S-adenosyl-l-methionine and N-acetylcysteine protective effects on acetaminophen hepatic toxicity. J Pharmacol Exp Ther 2007 320 : 99 107.
14. Bauer J. Antioxidants in health and disease, In : Ettinger SJ, Feldman EC. eds. Textbook of Veterinary Internal Medicine, 6th edn. Philadephia, PA : WB Saunders Co. 2005, p. 523.
15. Frezza M, Surrenti C, Manzillo G, et al. Oral S-adenosy-l-methionine in the symptomatic treatment of intrahepatic cholestasis. Gastroenterology 1990 99 : 211 215.
16. Webster CR. History, clinical signs, and physical findings in hepatobiliary disease, In : Ettinger SJ, Feldman EC. eds. Textbook of Veterinary Internal Medicine, 6th edn. Philadephia, PA : WB Saunders Co. 2005, p. 1426.