Prepared and screened a modified TNF-α molecule as TNF-α autovaccine to treat LPS induced endotoxic shock and TNF-α induced cachexia in mouse

Cellular Immunology

Volumn 246, Issue 2, 2007, Pages 55-64

  Wan, Yi ^a,c   Xue, Xiaochang ^a,b   Li, Meng ^a,b   Zhang, Xiaoyong ^a   Qin, Xin ^a,b   Zhang, Cun ^a,b   You, Yanjie ^a,b   Wang, Weihua ^a,b   Jiang, Changli ^a,b   Wu, Shouzhen ^a,b   Liu, Yan ^a,b   Zhu, Wenhua ^a,b   Ran, Yonggang ^a,b   Zhang, Zhen ^a,b   Han, Wei ^a,b   Zhang, Yingqi ^a,b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b State Key Laboratory of Cancer Biology   (China)

^c Shaanxi Microbiology Institute   (China)

Author keywords

Adjuvant; Autovaccine; Cachexia; Endotoxic shock; T cell helper epitope; TNF

Indexed keywords

ALANYLLYSYLPHENYLALANYLVALYLALANYLALANYLTRYPTOPHYLTHREONYLLEUCYLLYSYL ALANINE; AMINO ACID; ASPARAGINYLTHREONYLASPARTYLGLYCYLSERYLTHREONYLASPARTYLTYROSYLGLYCYL ISOLEUCYLLEUCYLGLUTAMINYLISOLEUCYLASPARAGINYLSERYLARGININE; EPITOPE; GLUTAMINYLTYROSYLISOLEUCYLLYSYLALANYLASPARAGINYLSERYLLYSYLPHENYL ALANYLISOLEUCYLGLYCYLISOLEUCYLTHREONYLGLUTAMYLLEUCINE; HYBRID PROTEIN; LIPOPOLYSACCHARIDE; RECOMBINANT VACCINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CACHEXIA; CONTROLLED STUDY; CYTOLYSIS; DRUG EFFECT; DRUG SCREENING; DRUG SYNTHESIS; ESCHERICHIA COLI; HELPER CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOGENICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SEPTIC SHOCK; VACCINATION;

AMINO ACID SEQUENCE; ANIMALS; AUTOANTIBODIES; CACHEXIA; EPITOPES, T-LYMPHOCYTE; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; RECOMBINANT FUSION PROTEINS; SHOCK, SEPTIC; TUMOR NECROSIS FACTOR-ALPHA; VACCINES;

ESCHERICHIA COLI; MUS;

EID: 34548128259     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2007.05.005     Document Type: Article

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