Insertion of foreign T cell epitopes in human tumor necrosis factor α with minimal effect on protein structure and biological activity

Journal of Biological Chemistry

Volumn 279, Issue 32, 2004, Pages 33593-33600

  Nielsen, Finn Stausholm ^a   Sauer, Jørgen ^b   Bäcklund, Johan ^a   Voldborg, Bjørn ^a   Gregorius, Klaus ^c   Mouritsen, Søren ^a   Bratt, Tomas ^a  

^a Pharmexa AS   (Denmark)

^b ALK ABELLÓ   (Denmark)

^c NONE   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; BIOCHEMISTRY; MONOMERS; NEUROSURGERY; TUMORS;

BIOLOGICAL ACTIVITIES; CYSTEINE; TERTIARY STRUCTURES; TUMOR NEUROSIS FACTOR (TNF);

VACCINES;

ALANINE; ARGININE; ASPARAGINE; ASPARTIC ACID; CYSTEINE; EPITOPE; FOREIGN EPITOPE; MONOMER; MUTANT PROTEIN; OLIGOMER; SERINE; TRIMER; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; TYROSINE; UNCLASSIFIED DRUG; VACCINE;

ANTIBODY PRODUCTION; ARTICLE; CIRCULAR DICHROISM; CROSS REACTION; CYTOTOXICITY; DISULFIDE BOND; HELPER CELL; HUMAN; HUMAN CELL; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; MOLECULAR INTERACTION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; PROTEIN VARIANT; SIGNAL TRANSDUCTION; SOLUBILITY; T LYMPHOCYTE; VACCINE PRODUCTION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY SPECIFICITY; BINDING SITES; CIRCULAR DICHROISM; CYSTEINE; DISULFIDES; EPITOPES; HUMANS; IMMUNE SERA; IMMUNIZATION; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA; VACCINES;

INSERTION SEQUENCES;

EID: 4043091394     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M403072200     Document Type: Article

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