Large cell neuroendocrine carcinoma of the uterine cervix exhibiting TTF1 immunoreactivity [1]

Histopathology

Volumn 51, Issue 3, 2007, Pages 405-407

  McCluggage, W G ^a   Sargent, A ^b   Bailey, A ^b   Wilson, G E ^b  

^a ROYAL GROUP OF HOSPITALS TRUST   (United Kingdom)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPLATIN; CD56 ANTIGEN; CHROMOGRANIN; ETOPOSIDE; GENE PRODUCT; SYNAPTOPHYSIN; THYROID TRANSCRIPTION FACTOR 1;

ADENOCARCINOMA; ADULT; AGED; CANCER CHEMOTHERAPY; CANCER STAGING; CASE REPORT; FEMALE; HISTOLOGY; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPE 18; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LARGE CELL NEUROENDOCRINE CARCINOMA; LETTER; LYMPHADENOPATHY; METASTASIS; MITOSIS RATE; NEUROENDOCRINE TUMOR; NEUROSECRETORY CELL; PATHOLOGY; PRIORITY JOURNAL; RADICAL HYSTERECTOMY; UTERINE CERVIX; UTERINE CERVIX BIOPSY; UTERINE CERVIX CANCER; WART VIRUS;

ADULT; AGED; CARCINOMA, LARGE CELL; CARCINOMA, NEUROENDOCRINE; CELL NUCLEUS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS; UTERINE CERVICAL NEOPLASMS;

EID: 34548118811     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2007.02773.x     Document Type: Letter

References (16)

1. Gilks CB, Young RH, Gersell DJ, Clement PB. Large cell neuroendocrine carcinoma of the uterine cervix: a clinicopathologic study of 12 cases. Am. J. Surg. Pathol. 1997 21 905 914.
2. Sato S, Shimamoto T, Amada S et al. Large cell neuroendocrine carcinoma of the uterine cervix: a clinicopathological study of six cases. Int. J. Gynecol. Pathol. 2003 22 226 230.
3. Rhemtula H, Grayson W, van Iddekinge B, Tiltman A. Large-cell neuroendocrine carcinoma of the uterine cervix - a clinicopathological study of five cases. S Afr. Med. J. 2001 91 525 528.
4. Albores-Saavedra J, Gilks CB, Gersell D et al. Terminology of endocrine tumors of the uterine cervix. Results of a workshop sponsored by the College of American Pathologists and the National Cancer Institute. Arch. Pathol. Lab. Med. 1997 121 34 39.
5. Tavassoli FA, Devilee P, eds. World Health Organization classification of tumours. Pathology and genetics. Tumours of the breast and female genital organs. Lyon : IARC Press 2003.
6. Travis WD, Linnoila RI, Tsokos MG et al. Neuroendocrine tumors of the lung with proposed criteria for large-cell neuroendocrine carcinoma. An ultrastructural, immunohistochemical and flow cytometric study of 35 cases. Am. J. Surg. Pathol. 1991 15 529 553.
7. Cetiner H, Kir G, Akoz I et al. Large-cell neuroendocrine carcinoma of the cervix associated with cervical-type invasive adenocarcinoma: a report of a case and discussion of histogenesis. Int. J. Gynecol. Cancer 2006 16 438 442.
8. Tsou MH, Tan TD, Cheng SH, Chiou YK. Small cell carcinoma of the uterine cervix with large cell neuroendocrine carcinoma component. Gynecol. Oncol. 1998 68 69 72.
9. Grayson W, Rhemtula HA, Taylor LF et al. Detection of human papillomavirus in large cell neuroendocrine carcinoma of the uterine cervix: a study of 12 cases. J. Clin. Pathol. 2002 55 108 114.
10. Kaufmann O, Dietl M. Thyroid transcription factor-1 is the superior immunohistochemical marker for pulmonary adenocarcinomas and large cell carcinomas compared to surfactant proteins A and B. Histopathology 2000 36 8 16.
11. Agoff SN, Lamp LW, Philip AT et al. Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumors. Mod. Pathol. 2000 13 238 242.
12. Cheuk W, Kwan MY, Suster S, Chan JK. Immunostaining for thyroid transcription factor 1 and cytokeratin 20 aids the distinction of small cell carcinoma from Merkel cell carcinoma, but not pulmonary from extrapulmonary small cell carcinomas. Arch. Pathol. Lab. Med. 2001 125 228 231.
13. Jones TD, Kernek KM, Yang XJ et al. Thyroid transcription factor 1 expression in small cell carcinoma of the urinary bladder: an immunohistochemical profile of 44 cases. Hum. Pathol. 2005 36 718 723.
14. Ordonez NG. Value of thyroid transcription factor-1 immunostaining in distinguishing small cell lung carcinomas from other small cell carcinomas. Am. J. Surg. Pathol. 2000 24 1217 1223.
15. O'Neill CJ, McCluggage WG. p16 expression in the female genital tract and its value in diagnosis. Adv. Anat. Pathol. 2006 13 8 15.
16. Graham AD, Williams ARW, Salter DM. TTF-1 expression in primary ovarian epithelial neoplasia. Histopathology 2006 48 764 765.