Subantimicrobial dose doxycycline effects on alveolar bone loss in post-menopausal women

Journal of Clinical Periodontology

Volumn 34, Issue 9, 2007, Pages 776-787

  Payne, Jeffrey B ^a   Stoner, Julie A ^b   Nummikoski, Pirkka V ^c   Reinhardt, Richard A ^a   Goren, Arthur D ^d   Wolff, Mark S ^e   Lee, Hsi Ming ^d   Lynch, James C ^b   Valente, Robert ^f   Golub, Lorne M ^d  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d STONY BROOK UNIVERSITY   (United States)

^e NEW YORK UNIVERSITY   (United States)

^f Arthritis Center of Nebraska   (United States)

Author keywords

Computer assisted densitometric image analysis (CADIA); Dual energy X ray absorptiometry (DEXA); Osteopenia; Periodontal maintenance; Periodontitis; Post menopausal; Radiographic absorptiometry (RA) method; Randomized clinical trial

Indexed keywords

ANTIINFECTIVE AGENT; DOXYCYCLINE; PLACEBO;

AGED; ARTICLE; BONE DENSITY; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; FOLLOW UP; HUMAN; IMAGE PROCESSING; JAW; METABOLIC BONE DISEASE; MIDDLE AGED; OSTEOLYSIS; PERIODONTITIS; POSTMENOPAUSE; POSTMENOPAUSE OSTEOPOROSIS; RADIODENSITOMETRY; RANDOMIZED CONTROLLED TRIAL; SMOKING; TOOTH RADIOGRAPHY; TREATMENT OUTCOME;

AGED; ALVEOLAR BONE LOSS; ALVEOLAR PROCESS; ANTI-BACTERIAL AGENTS; BONE DENSITY; BONE DISEASES, METABOLIC; DENSITOMETRY, X-RAY; DOUBLE-BLIND METHOD; DOXYCYCLINE; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; PERIODONTAL POCKET; PERIODONTITIS; PLACEBOS; POSTMENOPAUSE; RADIOGRAPHY, BITEWING; SMOKING; TREATMENT OUTCOME;

EID: 34548104923     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2007.01115.x     Document Type: Article

References (41)

1. Bain, S., Ramamurthy, N. S., Impeduglia, T., Scolman, S., Golub, L. M. Rubin, C. (1997) Tetracycline prevents cancellous bone loss and maintains near-normal rates of bone formation in streptozotocin-diabetic rats. Bone 21, 147 153.
2. Caton, J. G., Ciancio, S. G., Blieden, T. M., Bradshaw, M., Crout, R. J., Hefti, A. F., Massaro, J. M., Polson, A. M., Thomas, J. Walker, C. (2000) Treatment with subantimicrobial dose doxycycline improves the efficacy of scaling and root planing in patients with adult periodontitis. Journal of Periodontology 71, 521 532.
3. Caton, J. G., Ciancio, S. G., Blieden, T. M., Bradshaw, M., Crout, R. J., Hefti, A. F., Massaro, J. M., Polson, A. M., Thomas, J. Walker, C. (2001) Subantimicrobial dose doxycycline as an adjunct to scaling and root planing: post-treatment effects. Journal of Clinical Periodontology 28, 782 789.
4. Ciancio, S. Ashley, R. (1998) Safety and efficacy of sub-antimicrobial- dose doxycycline therapy in patients with adult periodontitis. Advances in Dental Research 12, 27 31.
5. Civitelli, R., Pilgram, T. K., Dotson, M., Muckerman, J., Lewandowski, N., Armamento-Villareal, R., Yokoyama-Crothers, N., Kardaris, E. E., Hauser, J., Cohen, S. Hildebolt, C. F. (2002) Alveolar and postcranial bone density in postmenopausal women receiving hormone/estrogen replacement therapy: a randomized, double-blind, placebo-controlled trial. Archives of Internal Medicine 162, 1409 1415.
6. Craig, R. G., Yu, Z., Xu, L., Barr, R., Ramamurthy, N., Boland, J., Schnier, M. Golub, L. M. (1998) A chemically modified tetracycline inhibits streptozotocin-induced diabetic depression of skin collagen synthesis and steady-state type I procollagen mRNA. Biochimica et Biophysica Acta 1402, 250 260.
7. Cranney, A., Guyatt, G., Griffith, L., Wells, G., Tugwell, P. Rosen, C. Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group 2002) Meta-analyses of therapies for postmenopausal osteoporosis. IX: summary of meta-analyses of therapies for postmenopausal osteoporosis. Endocrine Reviews 23, 570 578.
8. Giannobile, W. V., Lynch, S. E., Denmark, R. G., Paquette, D. W., Fiorellini, J. P. Williams, R. C. (1995) Crevicular fluid osteocalcin and pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) as markers of rapid bone turnover in periodontitis. A pilot study in beagle dogs. Journal of Clinical Periodontology 22, 903 910.
9. Golub, L. M., Lee, H. M., Greenwald, R. A., Ryan, M. E., Sorsa, T., Salo, T. Giannobile, W. V. (1997) A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis. Inflammation Research 46, 310 319.
10. Golub, L. M., Lee, H. M., Lehrer, G., Nemiroff, A., McNamara, T. F., Kaplan, R. Ramamurthy, N. S. (1983) Minocycline reduces gingival collagenolytic activity during diabetes: preliminary observations and a proposed new mechanism of action. Journal of Periodontal Research 18, 516 526.
11. Golub, L. M., Lee, H. M., Ryan, M. E., Giannobile, W. V., Payne, J. Sorsa, T. (1998) Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms. Advances in Dental Research 12, 12 26.
12. Golub, L. M., Ramamurthy, N. S., Kaneko, H., Sasaki, T., Rifkin, B. McNamara, T. F. (1990) Tetracycline administration prevents diabetes-induced osteopenia in the rat: initial observations. Research Communications in Chemical Pathology and Pharmacology 68, 27 40.
13. Golub, L. M., Ramamurthy, N. S., Llavaneras, A., Ryan, M. E., Lee, H. M., Liu, Y., Bain, S. Sorsa, T. (1999) A chemically-modified nonantimicrobial tetracycline (CMT-8) inhibits gingival matrix metalloproteinases, periodontal breakdown, and extra-oral bone loss in ovariectomized rats. Annals of the New York Academy of Sciences 878, 290 310.
14. Hausmann, E., Allen, K., Carpio, L., Christersson, L. A. Clerehugh, V. (1992) Computerized methodology for detection of alveolar crestal bone loss from serial intraoral radiographs. Journal of Periodontology 63, 657 662.
15. Hildebolt, C. F., Pilgram, T. K., Dotson, M., Armamento-Villareal, R., Hauser, J., Cohen, S. Civitelli, R. (2004) Estrogen and/or calcium plus vitamin D increase mandibular bone mass. Journal of Periodontology 75, 811 816.
16. Hildebolt, C. F., Pilgram, T. K., Yokoyama-Crothers, N., Vannier, M. W., Dotson, M., Muckerman, J., Hauser, J., Cohen, S., Kardaris, E. E., Hanes, P., Shrout, M. K. Civitelli, R. (2000) Alveolar bone height and postcranial bone mineral density: negative effects of cigarette smoking and parity. Journal of Periodontology 71, 683 689.
17. Hujoel, P. P., Baab, D. A. DeRouen, T. A. (1993) Measures of treatment efficacy. Journal of Clinical Periodontology 20, 601 605.
18. Jeffcoat, M. K., Reddy, M. S., Webber, R. L., Williams, R. C. Ruttimann, U. (1987) Extra oral control of geometry for digital subtraction radiography. Journal of Periodontal Research 22, 396 402.
19. Kaldahl, W. B., Kalkwarf, K. L., Patil, K. D., Molvar, M. P. Dyer, J. K. (1996) Long-term evaluation of periodontal therapy: II. Incidence of sites breaking down. Journal of Periodontology 67, 103 108.
20. Kuhl, E. D. Nummikoski, P. V. (2000) Radiographic absorptiometry method in measurement of localized alveolar bone density changes. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics 89, 375 381.
21. Liang, K. Y. Zeger, S. L. (1986) Longitudinal data analysis using generalized linear models. Biometrika 73, 13 22.
22. Lindsay, R., Hart, D. M., Forrest, C. Baird, C. (1980) Prevention of spinal osteoporosis in oophorectomised women. Lancet 2, 1151 1154.
23. Looker, A. C., Orwoll, E. S., Johnston, C. C. Jr., Lindsay, R. L., Wahner, H. W., Dunn, W. L., Calvo, M. S., Harris, T. B. Heyse, S. P. (1997) Prevalence of low femoral bone density in older U.S. Adults from NHANES III. Journal of Bone and Mineral Research 12, 1761 1768.
24. North American Menopause Society 2006) The role of calcium in peri- and postmenopausal women: 2006 position statement of the North American Menopause Society. Menopause 13, 862 877.
25. Osborn, J. B., Stoltenberg, J. L., Huso, B. A., Aeppli, D. M. Pihlstrom, B. L. (1992) Comparison of measurement variability in subjects with moderate periodontitis using a conventional and constant force periodontal probe. Journal of Periodontology 63, 283 289.
26. Pacifici, R., Rifas, L., McCracken, R., Vered, I., McMurtry, C., Avioli, L. V. Peck, W. A. (1989) Ovarian steroid treatment blocks a postmenopausal increase in blood monocyte interleukin 1 release. Proceedings of the National Academy of Sciences of the United States of America 86, 2398 2402.
27. Payne, J. B., Reinhardt, R. A., Nummikoski, P. V., Dunning, D. G. Patil, K. D. (2000) The association of cigarette smoking with alveolar bone loss in postmenopausal females. Journal of Clinical Periodontology 27, 658 664.
28. Payne, J. B., Reinhardt, R. A., Nummikoski, P. V. Patil, K. D. (1999) Longitudinal alveolar bone loss in postmenopausal osteoporotic/osteopenic women. Osteoporosis International 10, 34 40.
29. Payne, J. B., Zachs, N. R., Reinhardt, R. A., Nummikoski, P. V. Patil, K. D. (1997) The association between estrogen status and alveolar bone density changes in postmenopausal women with a history of periodontitis. Journal of Periodontology 68, 24 31.
30. Pocock, S. J. (1997) Clinical trials with multiple outcomes: a statistical perspective on their design, analysis and interpretation. Controlled Clinical Trials 18, 530 545.
31. Preshaw, P. M., Hefti, A. F., Novak, M. J., Michalowicz, B. S., Pihlstrom, B. L., Schoor, R., Trummel, C. L., Dean, J., Van Dyke, T. E., Walker, C. B. Bradshaw, M. H. (2004) Subantimicrobial dose doxycycline enhances the efficacy of scaling and root planing in chronic periodontitis: a multicenter trial. Journal of Periodontology 75, 1068 1076.
32. Rifkin, B. R., Vernillo, A. T., Golub, L. M. Ramamurthy, N. S. (1994) Modulation of bone resorption by tetracyclines. Annals of the New York Academy of Sciences. 732, 165 180.
33. Riggs, B. L. Melton, L. J. (1986) Involutional osteoporosis. New England Journal of Medicine 314, 1676 1686.
34. Risteli, J., Elomaa, I., Niemi, S., Novamo, A. Risteli, L. (1993) Radioimmunoassay for the pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen: a new serum marker of bone collagen degradation. Clinical Chemistry 39, 635 640.
35. Rochon, J. (1998) Application of GEE procedures for sample size calculations in repeated measures experiments. Statistics in Medicine 17, 1643 1658.
36. Rüttimann, U. E., Webber, R. L. Schmidt, E. (1986) A robust digital method for film contrast correction in dental radiographs. Journal of Periodontal Research 21, 486 495.
37. Sanchez, J., Somolinos, A. L., Almodovar, P. I., Webster, G., Bradshaw, M. Powala, C. (2005) A randomized, double-blind, placebo-controlled trial of the combined effect of doxycycline hyclate 20-mg tablets and metronidazole 0.75% topical lotion in the treatment of rosacea. Journal of the American Academy of Dermatology 53, 791 797.
38. Sasaki, T., Ramamurthy, N. S. Golub, L. M. (1992) Tetracycline administration increases collagen synthesis in osteoblasts of streptozotocin-induced diabetic rats: a quantitative autoradiographic study. Calcified Tissue International 50, 411 419.
39. Skidmore, R., Kovach, R., Walker, C., Thomas, J., Bradshaw, M., Leyden, J., Powala, C. Ashley, R. (2003) Effects of subantimicrobial-dose doxycycline in the treatment of moderate acne. Archives of Dermatology 139, 459 464.
40. Tezal, M., Wactawski-Wende, J., Grossi, S. G., Dmochowski, J. Genco, R. J. (2005) Periodontal disease and the incidence of tooth loss in postmenopausal women. Journal of Periodontology 76, 1123 1128.
41. Williams, S., Wakisaka, A., Zeng, Q. Q., Barnes, J., Martin, G., Wechter, W. J. Liang, C. T. (1996) Minocycline prevents the decrease in bone mineral density and trabecular bone in ovariectomized aged rats. Bone 19, 637 644.