A golgi analysis of cortical pyramidal cells in the unilateral parkinson rat: Absence of change in the affected hemisphere vs hypertrophy in the intact hemisphere

Restorative Neurology and Neuroscience

Volumn 25, Issue 2, 2007, Pages 91-99

  Miklyaeva, Elena I ^a   Whishaw, Ian Q ^a   Kolb, Bryan ^a  

^a UNIVERSITY OF LETHBRIDGE   (Canada)

Author keywords

6 OHDA lesion; Dendritic arborization and dopamine; Dopamine; Dopamine and cortical neurons; Dopamine depletion; Golgi and dopamine; Nigrostriatal bundle lesion; Parkinson rat; Skilled reaching; Spine density

Indexed keywords

AMPHETAMINE; APOMORPHINE; DOPAMINE; OXIDOPAMINE;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STRUCTURE; CIRCLING BEHAVIOR; CONTROLLED STUDY; FEMALE; FRONTAL CORTEX; GOLGI COMPLEX; HEMISPHERE; MOTOR DYSFUNCTION; NEOCORTEX; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SENSORIMOTOR FUNCTION; STAINING;

ANIMALS; APOMORPHINE; CEREBRAL CORTEX; DENDRITES; DENDRITIC SPINES; DEXTROAMPHETAMINE; FEMALE; FORELIMB; GOLGI APPARATUS; HYPERTROPHY; MOTOR ACTIVITY; MOTOR CORTEX; OXIDOPAMINE; PARKINSON DISEASE, SECONDARY; PSYCHOMOTOR PERFORMANCE; PYRAMIDAL CELLS; RATS; RATS, LONG-EVANS; ROTATION; SYNAPSES;

EID: 34548063226     PISSN: 09226028     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Bennett, D. J., Xu, Y., Hollerbach, J. M., & Hunter, I. W. (1989). Identifying the mechanical impedance of the elbow joint during posture and movement, Soc Neurosci Abs, 15, 396.
2. Boecker, H., Ceballos-baumann, A., Bartenstein, P., Weindl, A., Siebner, H. R., Fassbender, T., et al., (1999). Sensory processing in Parkinson's disease and Huntington's disease: Investigations with 3D H20-Pet, Brain, 122, 1651-1751.
3. Buhmann, C., Glauche, V., Sturenburg, H. J., Oechsner, M., Weiller, C., & Buchel, C. (2003). Pharmacologically modulated fMRI-cortical responsiveness to levodopa in drug-naïve hemiparkinsonian patients, Brain, 126, 451-461.
4. Cenci, M. A., Whishaw, I. Q., & Schallert, T. (2002). Animal models of neurological deficits: how relevant is the rat? Nat Rev Neurosci, 3, 574-579.
5. Chadha, A., Dawson, L. G., Jenner, P. G., & Duty, S. (2000). Effect of unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway on GABA(A) receptor subunit gene expression in the rodent basal ganglia and thalamus, Neuroscience, 95, 119-126.
6. DeLong, M. R., & Wichmann, T. (1993). Basal gangliathalamocortical circuits in Parkinsonian signs, Clin Neurosci, 1, 18-26.
7. Donoghue, J. P., & Wise, S. P. (1982). The motor cortex of the rat: Cytoarchitecture and microstimulation mapping, J Compar Neurol, 212, 76-88.
8. Dunnett, S. B., Whishaw, I. Q., Rogers, D. C., & Jones, G. H. (1987). Dopamine rich grafts ameliorate whole body motor asymmetry and sensory neglect but not independent limb use in rats with 6-hydroxydopamine lesions, Brain Res, 415, 63-78.
9. Escola, L., Michelet, T., Macia, F., Guehl, D., Bioulac, B., & Burbaud, P. (2003). Disruption of information processing in the supplementary motor area of the MPTP-treated monkey: a clue to the pathophysiology of akinesia? Brain, 126, 95-114.
10. Evenden, J. L., & Robbins, T. W. (1984). Effects of unilateral 6-hydroxydopamine lesions of the caudate-putamen on skilled forepaw use in the rat, Behav Brain Res, 14, 61-68.
11. Florio, T., DiLoreto, S., Cerrito, F., & Scarnati, E. (1993). Influence of prelimbic and sensorimotor cortices on striatal neurons in the rat: electrophysiological evidence for converging inputs and the effects of 6-OHDA-induced degeneration of the substantia nigra, Brain Res, 619, 180-188.
12. Forgie, M., Gibb, R., & Kolb, B. (1996). Unilateral lesions of the forelimb area of rat motor cortex: Lack of evidence for use-dependent neural growth in the undamaged hemisphere, Brain Research, 710, 249-259.
13. Gibb, R., & Kolb, B. (1998). A method for vibratome sectioning of Golgi-Cox stained whole rat brain, Journal of Neuroscience Methods, 79, 1-4.
14. Gonzalez, C., & Kolb, B. (2003). A comparison of different models of stroke on behaviour and brain morphology, European Journal of Neuroscience, 18, 1950-1962.
15. Hamilton, M. H., Garcia-Munoz, M., & Arbuthnott, G. W. (1985), Separation of the motor consequences from other actions of unilateral 6-hydroxydopamine lesions in the nigrostriatal neurons of rat brain, Brain Res, 348, 220-228.
16. Hedreen, J. C. (1977), Corticostriatal cells identified by the peroxidase method, Neurosci Lett, 4, 1-7.
17. Hefti, F., Melamed, E., Sahakian, B. J., & Wurtman, R. J. (1980). Circling behavior in rats with partial unilateral nigrostriatal lesions: affect of amphetamine, apomorphine and dopa, Pharmacol Biochem Behav, 12, 185-188.
18. Hornykiewicz, O. (1973). Parkinson's disease: from brain homogenate to treatment, Fed Proc, 32, 183-190.
19. Ingham, C. A., Hood, S. H., van Maldegem, B., Weenink, A., & Arbuthnott, G. W. (1993). Morphological changes in the rat neostriatum after unilateral 6-hydroxy-dopamine injections into the nigrostriatal pathway, Exp Brain Res, 93, 17-27.
20. Jones, T. A. (1992). Dendritic overgrowth and pruning of pyramidal neurons after neocortical damage: relation to behavior, PhD thesis, Univ of Texas, Austin.
21. Jones, T. A., & Schallert, T. (1994). Use-dependent growth of pyramidal neurons after neocortical damage, J Neurosci, 14, 2140-2152.
22. Kleim, J. A., Ryder, R. C., Witt-Lajeunesse, A., Vandenberg, P.M., & Kolb, B. (2006). Emergence of movement representations within adult parietal cortex following neonatal frontal cortex damage, Manuscript in submission.
23. Klockgether, T., & Dichgans, J. (1994). Visual control of arm movement in Parkinson's disease, Movement Disord, 9, 48-56.
24. Kolb, B. (1995). Brain plasticity and behavior, Mahwah, NJ: Lawrence Erlbaum.
25. Kolb, B., Cote, S., Ribeiro-da-Silva, & Cuello, A. C. (1997). NGF stimulates recovery of function and dendritic growth after unilateral motor cortex lesions in rats, Neuroscience, 76, 1139-1151.
26. Kolb, B., Cioe, J., & Whishaw, I. Q. (2000). Is there an optimal age for recovery from motor cortex lesions? I. Behavioural and anatomical sequelae of bilateral motor cortex lesions in rats on postnatal days 1, 10, and in adulthood, Brain Research, 882, 62-74.
27. Kolb, B., & Whishaw, I. Q. (1998). Brain plasticity and behavior, Annual Review of Psychology, 49, 43-64.
28. Lazarus, A., & Stelmach, G. E. (1992). Interlimb coordination in Parkinson's disease, Movement Disord, 7, 159-170.
29. Magill, P. J., Bolam, J. P., & Bevan, M. D. (2001). Dopamine regulates the impact of the cerebral cortex on the subthalamic nucleus-globus pallidus network, Neuroscience, 106, 313-330.
30. Marshall, J. F., & Ungerstedt, U. (1977). Supersensitivity to apomorphine following destruction of the ascending dopamine neurons: quantification using the rotational model, Eur J Pharmacol, 41, 361-367.
31. 125I] Iodosulpride, a highly selective ligand, Science, 28, 752-755.
32. Meredith, G. E., Ypma, P., & Zahm, D.S. (1995). Effects of dopamine depletion on the morphology of medium spiny neurons in the shell and core of the rat nucleus accumbens, J Neurosci, 15, 3808-3820.
33. Metz, G. A., & Whishaw, I. Q. (2002). Cortical and subc ortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and coordination, J Neurosci Method, 115, 169-179.
34. Miklyaeva, E. I., Castaneda, E., & Whishaw, I. Q. (1994). Skilled reaching deficits in unilateral dopamine-depleted rats: impairments in movement and posture and compensatory adjustments, J Neurosci, 14, 7148-7158.
35. Miklyaeva, E. I., Martins, D. J., & Whishaw, I. Q. (1995). Impairments and compensatory adjustments in spontaneous movement after unilateral dopamine depletion in rats, Brain Res, 681, 23-40.
36. Miklyaeva, E. I., & Whishaw, I. Q. (1996). HemiParkinson analog rats display active support in good limbs versus passive support in bad limbs on a skilled reaching task of variable height, Behav Neurosci, 110, 117-125.
37. Miklyaeva, E. I., Woodward, N. C., Nikiforov, E. G., Tompkins, G. J., Klassen, F., Ioffe, M. E., & Whishaw, I. Q. (1997), The ground reaction forces of postural adjustments during skilled reaching in unilateral dopamine-depleted hemiparkinson rats, Beh Brain Res, 88, 143-152.
38. Muir, G. D., & Whishaw, I. Q. (1999). Ground reaction forces in locomoting hemi-parkinsonian rats: a definitive test for impairments and compensations, Exp Brain Res, 126, 307-314.
39. Pang, Z., Ling, G. Y., Gajendiran, M., & Xu, Z. C. (2001). Enhanced excitatory synaptic transmission in spiny neurons of rat striatum after unilateral dopamine denervation, Neurosci Lett, 308, 201-205.
40. Pelled, G., Bergman, H., & Goelman, G. (2002). Bilateral overactivation of the sensorimotor cortex in the unilateral rodent model of Parkinson's disease - a functional magnetic resonance imaging study, Eur J Neurosci, 15, 389-394.
41. Porter, R., & Lemon, R. (1995). Corticospinal function and voluntary movement, Oxford: Clarendon Press.
42. Prusky, G., & Whishaw, I. Q. (1996). Morphology of identified corticospinal cells in the rat following motor cortex injury: absence of use-dependent change, Brain Res, 714, 1-8.
43. Robinson, T. E., Castañeda, E., & Whishaw, I. Q. (1990). Compensatory changes in striatal dopamine neurons following recovery from injury induced by 6-OHDA or methamphetamine: a review of evidence from microdialysis studies, Can J Psychol, 44, 253-275.
44. Sabatini, U., Boulanouar, K., Fabre, N., Martin, F., Carel, C., Colonnese, C., et al., (2000). Cortical motor reorganization in akinetic patients with Parkinson's disease: a functional MRI study, Brain, 123, 394-404.
45. Sabol, K. E., Neill, D. B., Wages, S. A., Church, W. H., & Justice, J. B. (1985). Dopamine depletion in a striatal subregion disrupts performance of a skilled motor task in the rat, Brain Res, 335, 108-120.
46. Schallert, T., Fleming, S. M., Leasure, J. L., Tillerson, J. L., & Bland, S. T. (2000). CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury, Neuropharmacology, 39, 777-787.
47. Schallert, T., Fleming, S. M., & Woodlee, M. T. (2003). Should the injured and intact hemispheres be treated differently during the early phases of physical restorative therapy in experimental stroke or parkinsonism? Phys Med Rehabil Clin N Am, 14, S27-46.
48. Schallert, T., & Jones, T. A. (1993). Exuberant neuronal growth after brain damage in adult rats: the essential role of behavioral experience, J Neurotransplant Plast, 4, 193-198.
49. Schultz, W. (1982). Depletion of dopamine in the striatum as an experimental model of Parkinsonism: direct effects and adaptive mechanisms, Prog Neurobiol, 18, 121-166.
50. Schwarting, R. K., & Huston, J. P. (1996). The unilateral 6-hydroxydopamine lesion model in behavioural brain research analysis of functional deficits, recovery, and treatments, Prog Neurobiol, 50, 275-331.
51. Sholl, D. A. (1956). The organization of the cerebral cortex, London: Methuen.
52. Siegfried, B., & Bures, J. (1980). Handedness in rats: blockade of reaching behavior by unilateral 6-OHDA injections into substantia nigra and caudate nucleus, Physiol Psychol, 8, 360-368.
53. Tillerson, J. L., Cohen, A. D., Caudle, W. M., Philhower, J., Miller, G. W., Zigmond, et al., (2001). J Neurosci, 21, 4427-4435.
54. Tillerson, J. L., Cohen, A. D., Caudle, W. M., Zigmond, M. J., Schallert, T., & Miller, G. W. (2002). Forced nonuse in unilateral parkinsonian rats exacerbates injury, J Neurosci, 22, 6790-6799.
55. Uguru-Okorie, D. C., & Arbuthnott, G. W. (1981). Altered paw preference after unilateral 6-hydroxydopamine injections into lateral hypothalamus, Neuropsychologia, 19, 463-467.
56. Vergara-Aragon, P., Gonzalez, C. L. R., & Whishaw, I. Q. (2003). A novel skilled-reaching impairment in paw supination on the "good" side of the hemi-Parkinson rat improved with rehabilitation, J Neurosci, 23, 579-586.
57. Whishaw, I. Q., O'Connor, W. T., & Dunnett, S. B. (1986). The contributions of motor cortex, nigrostriatal dopamine and caudateputamen to skilled forelimb use in the rat, Brain, 109, 805-843.
58. Whishaw, I. Q., Castaneda, E., & Gorny, B. P. (1992). Dopamine and skilled limb use in the rat: more severe bilateral impairments follow substantia nigra than sensorimotor cortex 6-hydroxydopamine injection, Behav Brain Res, 47, 89-92.
59. Whishaw, I. Q., Pellis, S. M., Gorny, B. P., Kolb, B., & Tetzlaff, W. (1993). Proximal and distal impairments in rat forelimb use in reaching follow unilateral pyramidal tract lesions, Behav Brain Res, 56, 59-76.
60. Withers, G. S., & Greenough, W. T. (1989). Reach training selectivity alters dendritic branching in subpopulations of layer II-III pyramids in rat motor-somatosensory forelimb cortex, Neuropsychologia, 27, 61-69.
61. Woolley, C. S., Gould, E., Frankfurt, M., & McEwen, B. S. (1990). Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons, J Neurosci, 10, 4035-4039.
62. Zilles, K. (1988). The cortex of the rat, Germany, Berlin: Springer.