Sodium pumps: Ouabain, ion transport, and signaling in hypertension [1]

American Journal of Physiology - Renal Physiology

Volumn 293, Issue 1, 2007, Pages

  Blaustein, Mordecai P ^a   Hamlyn, John M ^a   Pallone, Thomas L ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

17BETA (3 FURYL) 5BETA ANDROSTANE 3BETA,14BETA,17ALPHA TRIOL; 2 [4 (2,5 DIFLUOROBENZYLOXY)PHENOXY] 5 ETHOXYANILINE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) INHIBITOR; CALCIUM; CARDIOTONIC STEROID; CARRIER PROTEIN; DIGITALIS; DIGITOXIGENIN; DIGOXIN; HORMONE RECEPTOR; OUABAIN; STEROID; UNCLASSIFIED DRUG; CARDIOTONIC AGENT; ENZYME INHIBITOR;

BLOOD PRESSURE; CALCIUM CELL LEVEL; HYPERTENSION; ION TRANSPORT; LETTER; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SODIUM CALCIUM EXCHANGE; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM; NOTE; PATHOPHYSIOLOGY; PHYSIOLOGY;

CALCIUM; CARDIOTONIC AGENTS; CARRIER PROTEINS; ENZYME INHIBITORS; HUMANS; HYPERTENSION; NA(+)-K(+)-EXCHANGING ATPASE; OUABAIN; SIGNAL TRANSDUCTION; STEROIDS;

EID: 34548033959     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00092.2007     Document Type: Letter

References (10)

1. Abarquez RF Jr. Digitalis in the treatment of hypertension. A preliminary report. Acta Med Philipp 3: 161-170, 1967.
2. Dostanic I, Paul RJ, Lorenz JN, Theriault S, Van Huysse JW, Lingrel JB. The α2 isoform of Na,K-ATPase mediates ouabain-induced hypertension in mice and increased vascular contractility in vitro. Am J Physiol Heart Circ Physiol 288: H477-H485, 2005.
3. Dostanic-Larson I, Van Huysse JW, Lorenz JN, Lingrel JB. The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation. Proc Natl Acad Sci USA 102: 15845-15850, 2005.
4. Ferrari P, Ferrandi M, Tripodi G, Torielli L, Padoani G, Minotti E, Melloni P, Bianchi G. PST 2238: a new antihypertensive compound that modulates Na,K-ATPase in genetic hypertension. J Pharmacol Exp Ther 288: 1074-1083, 1999.
5. 2+ exchanger type-1 in vascular smooth muscle. Nature Med 10: 1193-1199, 2004.
6. James PF, Grupp IL, Grupp G, Woo AL, Askew GR, Croyle ML, Welsh RA, Lingrel JB. Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart. Mol Cell 3: 555-563, 1999.
7. Kaunitz JD. Membrane transport proteins: not just for transport anymore. Am J Physiol Renal Physiol 290: F995-F996, 2006.
8. Manunta P, Hamilton BP, Hamlyn JM. Structure-activity relationships for the hypertensinogenic activity of ouabain: role of the sugar and lactone ring. Hypertension 37: 472-477, 2001.
9. Manunta P, Hamilton J, Rogowski AC, Hamilton BP, Hamlyn JM. Chronic hypertension induced by ouabain but not digoxin in the rat: antihypertensive effect of digoxin and digitoxin. Hypertens Res 23, Suppl: S77-S85, 2000.
10. Zhang J, Lee MY, Cavalli M, Chen L, Berra-Romani R, Balke CW, Bianchi G, Ferrari P, Hamlyn JM, Iwamoto T, Lingrel JB, Matteson DR, Wier WG, Blaustein MP. Sodium pump α2 subunits control myogenic tone and blood pressure in mice. J Physiol 569: 243-256, 2005.