Diverse humoral autoimmunity to the ribosomal P proteins in systemic lupus erythematosus and hepatitis C virus infection

Journal of Molecular Medicine

Volumn 85, Issue 9, 2007, Pages 953-959

  Kessenbrock, K ^a,h   Fritzler, M J ^b   Groves, M ^c   Eissfeller, P ^d   Von Muhlen C A ^e   Hopfl P ^f   Mahler, M ^g  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF CALGARY   (Canada)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d MIKROGEN GMBH   (Germany)

^e PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^f Thermo Fisher Scientific   (United States)

^g Dr Fooke Laboratorien GmbH   (Germany)

^h MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

Author keywords

Autoantibodies; HCV; Lupus; Peptide; Ribosomal P; SLE

Indexed keywords

RIBOSOME PROTEIN;

ADULT; ALPHA HELIX; AMINO TERMINAL SEQUENCE; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; AUTOIMMUNITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNOREACTIVITY; MALE; MICROARRAY ANALYSIS; MIXED CONNECTIVE TISSUE DISEASE; MOLECULAR RECOGNITION; MUTATIONAL ANALYSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDE SEQUENCE; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; RHEUMATOID ARTHRITIS; STRUCTURE ANALYSIS; SYSTEMIC LUPUS ERYTHEMATOSUS;

AMINO ACID SEQUENCE; AUTOANTIBODIES; AUTOIMMUNITY; EPITOPE MAPPING; EPITOPES; HEPATITIS C; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; RIBOSOMAL PROTEINS;

EID: 34548033234     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-007-0239-5     Document Type: Article

References (31)

1. Eber T, Chapman J, Shoenfeld Y (2005) Anti-ribosomal P-protein and its role in psychiatric manifestations of systemic lupus erythematosus: myth or reality? Lupus 14:571-575
2. Elkon K (1994) Ribosomal RNP. In: van Venrooij WJ and Maini RN (eds) Manual of biological markers of disease. Kluwer, Dordrecht, pp 1-11
3. Martin AL, Reichlin M (1996) Fluctuations of antibody to ribosomal P proteins correlate with appearance and remission of nephritis in SLE. Lupus 5:22-29
4. Reichlin M, Wolfson-Reichlin M (1999) Evidence for the participation of anti-ribosomal P antibodies in lupus nephritis. Arthritis Rheum 42:2728-2729
5. Torre JC, Mozo L, Suarez A, Ramos E, Gutierrez C (1996) Antibodies to ribosomal P proteins and hepatic damage in undifferentiated CTD. Ann Rheum Dis 55:562-563
6. Bonfa E, Golombek SJ, Kaufmann LD, Skelly S, Weissbach H, Brot N, Elkon KB (1987) Association between lupus psychosis and anti-ribosomal P protein antibodies. N Engl J Med 317:265-271
7. Mahler M, Kessenbrock K, Raats J, Fritzler MJ, Blüthner M (2003) Characterization of the human autoimmune response to the major C-terminal epitope of the ribosomal P proteins. J Mol Med 81:194-204
8. Greenwood DL, Gitlits VM, Alderuccio F, Sentry JW, Toh BH (2002) Autoantibodies in neuropsychiatric lupus. Autoimmunity 35:79-86
9. Nagai T, Arinuma Y, Yanagida T, Yamamoto K, Hirohata S (2005) Anti-ribosomal P protein antibody in human systemic lupus erythematosus up-regulates the expression of proinflammatory cytokines by human peripheral blood monocytes. Arthritis Rheum 2:847-855
10. Katzav A, Solodeev I, Brodsky O, Chapman J, Pick CG, Blank M, Zhang W, Reichlin M, Shoenfeld Y (2007) Induction of autoimmune depression in mice by anti-ribosomal P antibodies via the limbic system. Arthritis Rheum 56:938-948
11. Bruner BF, Wynn DM, Reichlin M, Harley JB, James JA (2005) Humoral antigenic targets of the ribosomal p0 lupus autoantigen are not limited to the carboxyl region. Ann N Y Acad Sci 1051:390-403
12. Lin JL, Dubljevic V, Fritzler MJ, Toh BH (2005) Major immunoreactive domains of human ribosomal P proteins lie N-terminal to a homologous C-22 sequence: application to a novel ELISA for systemic lupus erythematosus. Clin Exp Immunol 141:155-164
13. Elkon K, Skelly S, Parnassa A, Moller W, Danho W, Weissbach H, Brot N (1986) Identification and chemical synthesis of a ribosomal protein antigenic determinant in systemic lupus erythematosus. Proc Natl Acad Sci USA 83:7419-7423
14. Mesri EA, Levitus G, Hontebeyrie-Joskowicz M, Dighiero G, Van Regenmortel MH, Levin MJ (1990) Major Trypanosoma cruzi antigenic determinant in Chagas' heart disease shares homology with the systemic lupus erythematosus ribosomal P protein epitope. J Clin Microbiol 28:1219-1224
15. Ramos-Casals M, Font J, Garcia-Carrasco M, Cervera R, Jimenez S, Trejo O, de la Red G, Sanchez-Tapias JM, Ingelmo M (2000) Hepatitis C virus infection mimicking systemic lupus erythematosus: study of hepatitis C virus infection in a series of 134 Spanish patients with systemic lupus erythematosus. Arthritis Rheum 43:2801-2806
16. Ohira H, Takiguchi J, Rai T, Abe K, Yokokawa J, Sato Y, Takeda I, Kanno T (2004) High frequency of anti-ribosomal P antibody in patients with systemic lupus erythematosus-associated hepatitis. Hepatol Res 28:137-139
17. Cacoub P, Poynard T, Ghillani P, Charlotte F, Olivi M, Piette JC, Opolon P (1999) Extrahepatic manifestations of chronic hepatitis C. MULTIVIRC Group. Multidepartment Virus C. Arthritis Rheum 42:2204-2212
18. McMurray RW, Elbourne K (1997) Hepatitis C virus infection and autoimmunity. Semin Arthritis Rheum 26:689-701
19. Tzang BS, Chen TY, Hsu TC, Liu YC, Tsay GJ (1999) Presentation of autoantibody to proliferating cell nuclear antigen in patients with chronic hepatitis B and C virus infection. Ann Rheum Dis 58:630-634
20. Gaubitz M, Herrmann M, Shahin M, Schotte H, Willeke P, Domschke W (2001) Cat scratch disease (bartonellosis) mimicking an SLE flare. Lupus 10:883-885
21. Mahler M, Kessenbrock K, Szmyrka M, Takasaki Y, Garcia-De La Torre I, Shoenfeld Y, Hiepe F, Shun-le C, von Muhlen CA, Locht H, Hopfl P, Wiik A, Reeves W, Fritzler MJ (2006) International multicenter evaluation of autoantibodies to ribosomal P proteins. Clin Vaccine Immunol 13:77-83
22. Mahler M, Kessenbrock K, Raats J, Fritzler MJ (2004) Technical and clinical evaluation of anti-ribosomal P protein immunoassays. J Clin Lab Anal 18:215-223
23. Piotto M, Saudek V, Sklenar V (1992) Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions. J Biomol NMR 2:661-665
24. Sharp KA, Nicholls A, Friedman R, Honig B (1991) Extracting hydrophobic free energies from experimental data: relationship to protein folding and theoretical models. Biochemistry 30:9686-9697
25. Wuthrich K (1986) NMR of proteins and nucleic acids. Wiley, New York
26. Blüthner M, Mahler M, Müller DB, Dünzl H, Bautz FA (2000) Identification of an alpha-helical epitope region on the PM/Scl-100 autoantigen with structural homology to a region on the heterochromatin p25beta autoantigen using immobilized overlapping synthetic peptides. J Mol Med 78:47-54
27. Zampieri S, Mahler M, Blüthner M, Qiu Z, Malmegrim K, Ghirardello A, Doria A, van Venrooij WJ, Raats JM (2003) Recombinant anti-P protein autoantibodies isolated from a human autoimmune library: reactivity, specificity and epitope recognition. Cell Mol Life Sci 60:588-598
28. Soares MR, Bisch PM, Campos De Carvalho AC, Valente AP, Almeida FC (2004) Correlation between conformation and antibody binding: NMR structure of cross-reactive peptides from T. cruzi, human and L. braziliensis. FEBS Lett 560:134-140
29. Omagari K, Ohba K, Kadokawa Y, Hayashida K, Isomoto H, Takeshima F, Mizuta Y, Murata I, Kohno S (2003) Anti-extractable nuclear antigens (ENA) antibodies in patients with chronic hepatitis C before and after treatment with interferon. Autoimmunity 36:269-273
30. Ni J, Hembrador E, Di Bisceglie AM, Jacobson IM, Talal AH, Butera D, Rice CM, Chambers TJ, Dustin LB (2003) Accumulation of B lymphocytes with a naive, resting phenotype in a subset of hepatitis C patients. J Immunol 170:3429-3439
31. Arbuckle MR, McClain MT, Rubertone MV, Scofield RH, Dennis GJ, James JA, Harley JB (2003) Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med 349:1526-1533