Moderators and mediators of treatment outcome for youth with ADHD: Understanding for whom and how interventions work

Journal of Pediatric Psychology

Volumn 32, Issue 6, 2007, Pages 664-675

  Hinshaw, Stephen P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ADHD; Mediator; Moderator

Indexed keywords

ANXIETY DISORDER; ATTENTION DEFICIT DISORDER; BEHAVIOR THERAPY; COMORBIDITY; DISEASE COURSE; DISEASE SEVERITY; HUMAN; HYPERACTIVITY; INTELLIGENCE QUOTIENT; REVIEW; SOCIAL CARE; STATISTICAL SIGNIFICANCE; SYMPTOMATOLOGY; TREATMENT OUTCOME; ADOLESCENT; CHILD; CLINICAL TRIAL; EPIDEMIOLOGY; METHODOLOGY; POPULATION AND POPULATION RELATED PHENOMENA; PSYCHOLOGICAL ASPECT; RISK FACTOR;

ADOLESCENT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; CLINICAL TRIALS; COMORBIDITY; EPIDEMIOLOGIC FACTORS; EPIDEMIOLOGIC MEASUREMENTS; HUMANS; RESEARCH DESIGN; RISK FACTORS; TREATMENT OUTCOME;

EID: 34548029982     PISSN: 01468693     EISSN: 1465735X     Source Type: Journal    
DOI: 10.1093/jpepsy/jsl055     Document Type: Review

References (38)

1. Mannuzza, S., & Klein, R. G. (1999). Adolescent and adult outcome in attention-deficit/hyperactivity disorder. In H. C. Quay & A.E. Hogan (Eds.), Handbook of Disruptive Behavior Disorders (pp. 279-294). New York: Kluwer Academic/Plenum.
2. Jensen, P. S., Weersing, R., Hoagwood, K. E., & Goldman, E. (2005). What is the evidence for evidence-based treatments? A hard look at our soft underbelly. Ment Health Serv Res, 7, 53-74.
3. Hinshaw, S. P. (2002). Intervention research, theoretical mechanisms, and causal processes related to externalizing behavior patterns. Dev Psychopathol, 14, 789-818.
4. Kazdin, A. E., & Nock, M. K. (2003). Delineating mechanisms of change in child and adolescent therapy: methodological issues and research recommendations. J Child Psychol Psychiatry, 44, 1116-1129.
5. Paul, G. L., & Lentz, R. J. (1997). Psychosocial Treatment of Chronic Mental Patients: Milieu vs Social-Learning Paradigms. Mass: Harvard University Press Cambridge.
6. Hinshaw, S. P. (2002). Is ADHD an impairing condition in childhood and adolescence? In P. S. Jensen & J. R. Cooper (Eds.), Attention-Deficit Hyperactivity Disorder: State of the Science, Best Practices (pp. 5-1-5-21). Kingston, NJ: Civic Research Institute.
7. Baron, R. M., & Kenny, D. A. (1986). The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol, 51, 1173-1182.
8. Kraemer, H. C., Stice, E., Kazdin, A. E., et al. (2001). How do risk factors work together? Mediators, moderators, and independent, overlapping, and proxy risk factors. Am J Psychiatry, 158, 848-856.
9. Kraemer, H. C., Wilson, G. T., Fairburn, C. G., & Agras, W. S. (2002). Mediators and moderators of treatment effects in randomized clinical trials. Arch Gen Psychiatry, 69, 877-884.
10. McClelland, G. H., & Judd, C. M. (1993). Statistical difficulties of detecting interactions and moderator effects. Psychol Bull, 114, 376-390.
11. MacKinnon, D. P., Lockwood, C. M., Hoffman, J. M., et al. (2002). A comparison of methods to test mediation and other intervening variable effects. Psychol Methods, 7, 83-104.
12. Holmbeck, G. N. (2002). Post-hoc probing of significant moderational and mediational effects in studies of pediatric populations. J Pediatr Psychol, 27, 87-96.
13. Owens, E. B., Hinshaw, S. P., Kraemer, H. C., et al. (2003). Which treatment for whom for ADHD? Moderators of treatment response in the MTA. J Consult Clin Psychol, 71, 540-552.
14. Swanson, J. M., Kraemer, H. C., Hinshaw, S. P., et al. (2001). Clinical relevance of the primary findings of the MTA: success rates based on severity of ADHD and ODD symptoms at the end of treatment. J Am Acad Child Adolesc Psychiatry, 40, 168-179.
15. MTA Cooperative Group. (1999). Fourteen-month randomized clinical trial of treatment strategies for attention-deficit hyperactivity disorder. Arch Gen Psychiatry, 56, 1073-1086.
16. Smeraldi, E., Zanardi, R., Benedetti, F., et al. (1998). Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine. Mol Psychiatry, 3, 508-511.
17. Hinshaw, S. P., Owens, E. B., Wells, K. C., et al. (2000). Family processes and treatment outcome in the MTA: negative/ineffective parenting practices in relation to multimodal treatment. J Abnorm Child Psychol, 28, 555-568.
18. Costello, E. J., Compton, S. N., Keeler, G., & Angold, A. (2003). Relationships between poverty and psychopathology: a natural experiment. JAMA, 290, 2023-2029.
19. Eddy, J. M., & Chamberlain, P. (2000). Family management and deviant peer association as mediators of the impact of treatment condition on youth antisocial behavior. J Consult Clin Psychol, 68, 857-863.
20. Howe, G. W., Reiss, D., & Yuh, J. (2002). Can prevention trials test theories of etiology? Dev Psychopathol, 14, 673-694.
21. Hinshaw, S. P., Klein, R., & Abikoff, H. (2002). Nonpharmacologic treatments and their combination with medication. In P. E. Nathan & J. Gorman (Eds.), A Guide to Treatments That Work. 2nd ed. (pp. 3-23). New York: Oxford University Press.
22. Arnold, L. E., Abikoff, H., Cantwell, D. P., et al. (1997). National Institute of Mental Health Collaborative Multimodal Treatment Study of Children With ADHD (MTA): clinical design challenges and choices. Arch Gen Psychiatry, 54, 865-870.
23. Hinshaw, S. P., March, J. S., Abikoff, H., et al. (1997). Comprehensive assessment of childhood attention-deficit hyperactivity disorder in the context of a multisite, multimodal clinical trial. J Atten Disord, 1, 217-234.
24. Richters, J. E., Arnold, L. E., Jensen, P. S., et al. (1995). The National Institute of Mental Health Collaborative Multisite Multimodal Treatment Study of Children With Attention-Deficit Hyperactivity Disorder (MTA): I. Background and rationale. J Am Acad Child Adolesc Psychiatry, 34, 987-1000.
25. Conners, C. K., Epstein, J. N., March, J. S., et al. (2001). Multimodal treatment of ADHD in the MTA: an alternative outcome analysis. J Am Acad Child Adolesc Psychiatry, 40, 159-167.
26. MTA Cooperative Group. (2004a). National Institute of Mental Health Multimodal Treatment Study of ADHD follow-up: 24-month outcomes of treatment strategies for attention-deficit hyperactivity disorder. Pediatrics, 113, 754-761.
27. MTA Cooperative Group. (2004b). National Institute of Mental Health Multimodal Treatment Study of ADHD follow-up: changes in effectiveness of and growth after the end of treatment. Pediatrics, 113, 762-770.
28. MTA Cooperative Group. (1999). Moderators and mediators of treatment response for children with ADHD: the MTA Study. Arch Gen Psychiatry, 56, 1088-1096.
29. Hinshaw, S. P., & Blachman, D. R. (2005). Attention-deficit/ hyperactivity disorder. In D. Bell-Dolan, S. Foster & E. J. Mash (Eds.), Handbook of Behavioral and Emotional Problems in Girls (pp. 117-147). New York: Kluwer Academic/Plenum.
30. Jensen, P. S., Hinshaw, S. P., Kraemer, H. C., et al. (2001). ADHD comorbidity findings from the MTA study: comparing comorbid subgroups. J Am Acad Child Adolesc Psychiatry, 40, 147-158.
31. March, J. S., Swanson, J. M., Arnold, L. E., et al. (2000). Anxiety as a predictor and outcome variable in the Multimodal Treatment of Children With ADHD (MTA). J Abnorm Child Psychol, 28, 527-541.
32. Arnold, L. E., Elliott, M., Sachs, L., et al. (2003). Effects of ethnicity on treatment attendance, stimulant response/dose, and 14-month outcome in ADHD. J Consult Clin Psychol, 71, 713-727.
33. Jensen, P. S., Hoagwood, K. E., Roper, M., et al. (2004). The Services for Children and Adolescents Parent Interview (SCAPI): development and performance characteristics. J Am Acad Child Adolesc Psychiatry, 43, 1334-1344.
34. Tannock, R. (1998). Attention deficit hyperactivity disorder: advances in cognitive, neurobiological, and genetic research. J Child Psychol Psychiatry, 29, 65-99.
35. Johnston, C., & Mash, E. J. (2001). Families of children with attention-deficit/hyperactivity disorder: review and recommendations for future research. Clin Child Fam Psychol Rev, 4, 183-207.
36. Campbell, S. B. (2002). Behavior Problems in Preschool Children. 2nd ed. New York: Guilford Press.
37. Kazdin, A. E., & Weisz, J. R. (2003). Evidence-Based Psychotherapies for Children and Adolescents. New York: Guilford.
38. Weersing, V. R., & Weisz, J. R. (2002). Mechanisms of action of youth psychotherapy. J Child Psychol Psychiatry, 43, 3-29.