Functional transplant of photoactivated adenylyl cyclase (PAC) into Aplysia sensory neurons

Neuroscience Research

Volumn 59, Issue 1, 2007, Pages 81-88

  Nagahama, Tatsumi ^a   Suzuki, Takeshi ^b,c   Yoshikawa, Shinya ^d   Iseki, Mineo ^b,c  

^a TOHO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

^d FUKUI PREFECTURAL UNIVERSITY   (Japan)

Author keywords

Aplysia; cAMP; Learning; Light; PAC; Sensory neurons; Spike width; Transplant

Indexed keywords

ADENOSINE PHOSPHATE; ADENYLATE CYCLASE; CYCLIC AMP; ISOBUTYLMETHYLXANTHINE; PROTOZOAL PROTEIN; SEROTONIN;

ANIMAL CELL; APLYSIA; ARTICLE; CONTROLLED STUDY; ENZYME ISOLATION; EUGLENA; EXPRESSION VECTOR; GANGLION; INJECTION; LIGHT EXPOSURE; MOTONEURON; NERVE STIMULATION; NONHUMAN; PERIKARYON; PHOTOACTIVATION; PHOTOSTIMULATION; PRIORITY JOURNAL; PROTEIN FUNCTION; SENSORY NERVE CELL; SEROTONINERGIC SYSTEM; SPIKE; SYNAPTIC TRANSMISSION;

1-METHYL-3-ISOBUTYLXANTHINE; ADENYLATE CYCLASE; ANIMALS; APLYSIA; BEHAVIOR, ANIMAL; CYCLIC AMP; DRUG INTERACTIONS; EUGLENA; GANGLIA, INVERTEBRATE; MEMBRANE POTENTIALS; MICROINJECTIONS; NEURONS, AFFERENT; PATCH-CLAMP TECHNIQUES; PHOSPHODIESTERASE INHIBITORS; PHOTIC STIMULATION; SEROTONIN; TIME FACTORS;

EID: 34548018020     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neures.2007.05.015     Document Type: Article

References (29)

1. + channel expression genes in to a single identified neuron in Aplysia kurodai. Zool. Sci. 21 (2004) 369-373
2. Baxter D.A., and Byrne J.H. Serotonergic modulation of two potassium currents in the pleural sensory neurons of Aplysia. J. Neurophysiol. 62 (1989) 665-679
3. Baxter D.A., and Byrne J.H. Differential effects of cAMP and serotonin on membrane current, action-potential duration, and excitability in somata of pleural sensory neurons of Aplysia. J. Neurophysiol. 64 (1990) 978-990
4. Brunelli M., Castellucci V., and Kandel E.R. Synaptic facilitation and behavioral sensitization in Aplysia: possible role of serotonin and cyclic AMP. Science 194 (1976) 1178-1181
5. Byrne J.H. Neural and molecular mechanisms underlying information storage in Aplysia: implication for learning and memory. Trends Neurosci. 8 (1985) 478-482
6. Byrne J.H. Cellular analysis of associative learning. Physiol. Rev. 67 (1987) 329-439
7. Byrne J.H., and Kandel E.R. Presynaptic facilitation revisited: state and time dependence. J. Neurosci. 16 (1996) 425-435
8. Carew T.J., and Shaley C.L. Invertebrate learning: from behavior to molecules. Annu. Rev. Neurosci. 9 (1986) 435-487
9. Carew T.J., Castellucci V.F., and Kandel E.R. An analysis of dishabituation and sensitization of the gill-withdrawal reflex in Aplysia. Int. J. Neurosci. 2 (1971) 79-98
10. Davis R.L. Physiology and biochemistry of Drosophila learning mutants. Physiol. Rev. 76 (1996) 299-317
11. + current in the pleural sensory neurons of Aplysia by serotonin and cAMP: implications for spike broadening. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 11476-11480
12. Iseki M., Matsunaga S., Murakami A., Ohno K., Shiga K., Yoshida K., Sugai M., Takahashi T., Hori T., and Watanabe M. A blue-light-activated adenylyl cyclase mediates photoavoidance in Euglena gracilis. Nature 415 (2002) 1047-1051
13. Iseki M., Matsunaga S., Murakami A., and Watanabe M. Photoactivated adenylyl cyclase (PAC), the photoreceptor flavoprotein with intrinsic effector function mediating euglenoid photomovements. In: Silva E., and Edwards A.M. (Eds). Comprehensive Series in Photochemical & Photobiological Sciences, Flavins: Photochemistry and Photobiology (2006), RSC Publishing 271-286
14. Kaang B.K. Parameters influencing ectopic gene expression in Aplysia neurons. Neurosci. Lett. 221 (1996) 29-32
15. + channel gene modifies the electrical properties and synaptic efficacy of identified Aplysia neurons. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 1133-1137
16. Kandel E.R., and Schwartz J.H. Molecular biology of learning: modulation of transmitter release. Science 218 (1982) 433-443
17. Klein M., Camardo J., and Kandel E.R. Serotonin modulates a specific potassium current in the sensory neurons that show presynaptic facilitation in Aplysia. Proc. Natl. Acad. Sci. U.S.A. 79 (1982) 5713-5717
18. Mayford M., and Kandel E.R. Genetic approaches to memory storage. Trends Genet. 15 (1999) 463-470
19. Menzel R., and Müller U. Learning and memory in honeybees: from behavior to neural substrates. Annu. Rev. Neurosci. 19 (1996) 379-404
20. Ocorr K.A., Walters E.T., and Byrne J.H. Associative conditioning analog selectively increases cAMP levels of tail sensory neurons in Aplysia. Proc. Natl. Acad. Sci. U.S.A. 82 (1985) 2548-2552
21. Pollock J.D., Bernier L., and Camardo J.S. Serotonin and cyclic adenosine 3':5'-monophosphate modulate the potassium current in tail sensory neurons in the pleural ganglion of Aplysia. J. Neurosci. 5 (1985) 1862-1871
22. Schröder-Lang S., Schwärzel M., Seifert R., Strünker T., Kateriya S., Looser J., Watanabe M., Kaupp U.B., Hegemann P., and Nagel G. Fast manipulation of cellular cAMP level by light in vivo. Nat. Methods 4 (2007) 39-42
23. Schwartz J.H., and Greenberg S.M. Molecular mechanisms for memory: second-messenger induced modifications of protein kinases in nerve cells. Ann. Rev. Neurosci. 10 (1987) 459-476
24. Sugita S., Baxter D.A., and Byrne J.H. cAMP-independent effects of 8-(4-parachlorophenylthio)-cyclic AMP on spike duration and membrane currents in pleural sensory neurons of Aplysia. J. Neurophysiol. 73 (1994) 1250-1259
25. + current in tail sensory neurons of Aplysia: role of serotonin and cAMP. J. Neurophysiol. 61 (1989) 32-44
26. Walters E.T., and Byrne J.H. Associative conditioning of single sensory neurons suggests a cellular mechanism for learning. Science 219 (1983) 405-408
27. Walters E.T., Byrne J.H., Carew T.J., and Kandel E.R. Mechanoafferent neurons innervating tail of Aplysia. I. Response properties and synaptic connections. J. Neurophysiol. 50 (1983) 1522-1542
28. Walters E.T., Byrne J.H., Carew T.J., and Kandel E.R. Mechanoafferent neurons innervating tail of Aplysia. II. Modulation by sensitizing stimulation. J. Neurophysiol. 50 (1983) 1543-1559
29. Yoshikawa S., Suzuki T., Watanabe M., and Iseki M. Kinetic analysis of the activation of photoactivated adenylyl cyclase (PAC), a blue-light receptor for photomovements of Euglena. Photochem. Photobiol. Sci. 4 (2005) 727-731