Mechanism of action of a new antitumor ribonucleoside, 1-(3-C-ethynyl- β-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106), differs from that of 5-fluorouracil

Oncology Reports

Volumn 17, Issue 6, 2007, Pages 1453-1460

  Kazuno, Hiromi ^a   Shimamoto, Yuji ^a   Tsujimoto, Hiroaki ^a   Fukushima, Masakazu ^a   Matsuda, Akira ^b   Sasaki, Takuma ^c  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c AICHI GAKUIN UNIVERSITY   (Japan)

Author keywords

1 (3 C ethynyl D ribo pentofuranosyl)cytosine; 5 Fluorouracil; Cell cycle phase specificity; ECyd; Intracellular metabolism; RNA processing; TAS 106

Indexed keywords

1 (3 C ETHYNYLRIBOPENTOFURANOSYL)CYTOSINE; 1-(3-C-ETHYNYLRIBOPENTOFURANOSYL)CYTOSINE; ANTINEOPLASTIC AGENT; CYTIDINE; DRUG DERIVATIVE; FLUOROURACIL; RIBONUCLEOSIDE; RIBOSOME RNA; RNA PRECURSOR; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL PROLIFERATION; CHEMISTRY; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; IC 50; METABOLISM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYTIDINE; FLUOROURACIL; HUMANS; INHIBITORY CONCENTRATION 50; RIBONUCLEOSIDES; RNA PRECURSORS; RNA, RIBOSOMAL;

EID: 34548011036     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.17.6.1453     Document Type: Article

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