Antitumor activity and pharmacokinetics of TAS-106, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine

Japanese Journal of Cancer Research

Volumn 92, Issue 3, 2001, Pages 343-351

  Shimamoto, Yuji ^a   Fujioka, Akio ^a   Kazuno, Hiromi ^a   Murakami, Yuko ^a   Ohshimo, Hideyuki ^a   Kato, Toshiyuki ^a   Matsuda, Akira ^b   Sasaki, Takuma ^c   Fukushima, Masakazu ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c KANAZAWA UNIVERSITY   (Japan)

Author keywords

1 (3 C ethynyl D ribo pentofuranosyl)cytosine; Antitumor activity; Pharmacokinetics; TAS 106; TAS 106 nucleotides

Indexed keywords

3' ETHYNYLCYTIDINE; ANTINEOPLASTIC ANTIMETABOLITE; CYTOSINE DERIVATIVE; DRUG METABOLITE; NUCLEOSIDE DERIVATIVE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG EXPOSURE; DRUG MECHANISM; DRUG METABOLISM; DRUG TISSUE LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RADIOACTIVITY; RAT; RAT STRAIN; SOLID TUMOR; TUMOR CELL LINE; TUMOR XENOGRAFT;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BREAST NEOPLASMS; CELL SURVIVAL; COLONIC NEOPLASMS; CYTIDINE; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; PANCREATIC NEOPLASMS; RATS; RATS, INBRED F344; RATS, NUDE; STOMACH NEOPLASMS; TISSUE DISTRIBUTION; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0035066987     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2001.tb01101.x     Document Type: Article

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