Patients with rheumatoid arthritis have higher levels of mannan-binding lectin than their first-degree relatives and unrelated controls

Journal of Rheumatology

Volumn 34, Issue 8, 2007, Pages 1692-1694

  Saevarsdottir, Saedis ^a   Steinsson, Kristjan ^b   Grondal, Gerdur ^b   Valdimarsson, Helgi ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

Author keywords

Complement; Extended family; Mannan binding lectin; Rheumatoid arthritis; Rheumatoid factor

Indexed keywords

IMMUNOGLOBULIN; MANNAN BINDING LECTIN; RHEUMATOID FACTOR;

ARTICLE; CONTROLLED STUDY; EXTENDED FAMILY; FEMALE; GENE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; ICELAND; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MBL2 GENE; PRIORITY JOURNAL; RELATIVE; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID;

ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; FAMILY; FEMALE; HUMANS; MALE; MANNOSE-BINDING LECTIN; POLYMORPHISM, GENETIC; RHEUMATOID FACTOR;

EID: 34547960576     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Steinsson K, Alarcon-Riquelme M. Genetic aspects of rheumatic diseases. Scand J Rheumatol 2005;34:167-77.
2. Saevarsdottir S, Vikingsdottir T, Valdimarsson H. The potential role of mannan-binding lectin in the clearance of self-components including immune complexes. Scand J Immunol 2004;60:23-9.
3. Saevarsdottir S, Oskarsson OO, Aspelund T, et al. Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk. J Exp Med 2005;201:117-25.
4. Saevarsdottir S, Kristjansdottir H, Grondal G, Vikingsdottir T, Steinsson K, Valdimarsson H. Mannan binding lectin and complement C4A in Icelandic multicase families with systemic lupus erythematosus. Ann Rheum Dis 2006;65:1462-7.
5. Graudal NA, Homann C, Madsen HO, et al. Mannan binding lectin in rheumatoid arthritis. A longitudinal study. J Rheumatol 1998;25:629-35.
6. Ip WK, Lau YL, Chan SY, et al. Mannose-binding lectin and rheumatoid arthritis in southern Chinese. Arthritis Rheum 2000;43:1679-87.
7. Jacobsen S, Madsen HO, Klarlund M, et al. The influence of mannose binding lectin polymorphisms on disease outcome in early polyarthritis. TIRA Group. J Rheumatol 2001;28:935-42.
8. Graudal NA, Madsen HO, Tarp U, et al. The association of variant mannose-binding lectin genotypes with radiographic outcome in rheumatoid arthritis. Arthritis Rheum 2000;43:515-21.
9. Stanworth SJ, Donn RP, Hassall A, Dawes P, Ollier W, Snowden N. Absence of an association between mannose-binding lectin polymorphism and rheumatoid arthritis. Br J Rheumatol 1998;37:186-8.
10. Horiuchi T, Tsukamoto H, Morita C, et al. Mannose binding lectin (MBL) gene mutation is not a risk factor for systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in Japanese. Genes Immun 2000;1:464-6.
11. Barton A, Platt H, Salway F, et al. Polymorphisms in the mannose binding lectin (MBL) gene are not associated with radiographic erosions in rheumatoid or inflammatory polyarthritis. J Rheumatol 2004;31:442-7.
12. Saevarsdottir S, Vikingsdottir T, Vikingsson A, Manfredsdottir V, Geirsson AJ, Valdimarsson H. Low mannose binding lectin predicts poor prognosis in patients with early rheumatoid arthritis. A prospective study. J Rheumatol 2001;28:728-34.
13. Gupta B, Agrawal C, Raghav SK, et al. Association of mannose-binding lectin gene (MBL2) polymorphisms with rheumatoid arthritis in an Indian cohort of case-control samples. J Hum Genet 2005;50:583-91.
14. Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
15. Garred P, Madsen HO, Marquart H, et al. Two edged role of mannose binding lectin in rheumatoid arthritis: a cross sectional study. J Rheumatol 2000;27:26-34.
16. Arnold JN, Wormald MR, Suter DM, et al. Human serum IgM glycosylation: Identification of glycoforms which can bind to mannan binding lectin. J Biol Chem 2005;280:29080-7.
17. Troelsen LN, Garred P, Madsen HO, Jacobsen S. Genetically determined high serum levels of mannose-bindings lectin and agalactosyl IgG are associated with ischemic heart disease in rheumatoid arthritis. Arthritis Rheum 2007;56:21-9.