Variations of mitotic index in normal and dysplastic squamous epithelium of the uterine cervix as a function of endometrial maturation

Modern Pathology

Volumn 20, Issue 9, 2007, Pages 1000-1008

  Fadare, Oluwole ^a,b   Yi, Xiaofang ^c   Liang, Sharon X ^d   Ma, Yanling ^e   Zheng, Wenxin ^c,f  

^a WILFORD HALL MEDICAL CENTER   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^d STONY BROOK UNIVERSITY MEDICAL CENTER   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f FUDAN UNIVERSITY   (China)

Author keywords

Cervical intraepithelial neoplasia (CIN); Cervical squamous epithelium; Cervical squamous metaplasia; Menstrual hormones and CIN

Indexed keywords

ADULT; AGED; ANALYTIC METHOD; ARTICLE; CANCER STAGING; CONTROLLED STUDY; ENDOMETRIUM; FEMALE; HISTOPATHOLOGY; HUMAN; HYSTERECTOMY; MAJOR CLINICAL STUDY; MITOSIS; MITOSIS INDEX; PRIORITY JOURNAL; UTERINE CERVIX CARCINOMA IN SITU; UTERINE CERVIX DYSPLASIA; UTERINE CERVIX EPITHELIUM;

EID: 34547953380     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.3800935     Document Type: Article

References (42)

1. Hendrickson MR, Kempson RL. Normal histology of the uterus and fallopian tubes. In: Sternberg SS (ed). Histology for Pathologists, 2nd edn. Lippincott Williams and Wilkins: Philadelphia, 1997, pp 879-927.
2. Fu YS. Development, anatomy, and histology of the lower female genital tract. In: Fu YS (ed). Pathology of the Uterine Cervix, Vagina and Vulva, 2nd edn. Saunders: Philadelphia, 2002, pp 24-56.
3. Nucci MR, Crum CP. Redefining early cervical neoplasia: recent progress. Adv Anat Pathol 2007;14:1-10.
4. Al-Saleh W, Delvenne P, Greimers R, et al. Assessment of Ki-67 antigen immunostaining in squamous intraepithelial lesions of the uterine cervix. Correlation with the histologic grade and human papillomavirus type. Am J Clin Pathol 1995;104:154-160.
5. Kruse AJ, Baak JP, de Bruin PC, et al. Ki-67 immunostaining in cervical intraepithelial neoplasia (CIN): a sensitive marker for grading. J Pathol 2001;193:48-54.
6. Heatley MK. What is the value of proliferation markers in the normal and neoplastic cervix? Histol Histopathol 1998;13:249-254.
7. McCluggage WG, Buhidma M, Tang L, et al. Monoclonal antibody MIB1 in the assessment of cervical squamous intraepithelial lesions. Int J Gynecol Pathol 1996;15:131-136.
8. Shurbaji MS, Brooks SK, Thurmond TS. Proliferating cell nuclear antigen immunoreactivity in cervical intraepithelial neoplasia and benign cervical epithelium. Am J Clin Pathol 1993;100:22-26.
9. Pirog EC, Baergen RN, Soslow RA, et al. Diagnostic accuracy of cervical low-grade squamous intraepithelial lesions is improved with MIB-1 immunostaining. Am J Surg Pathol 2002;26:70-75.
10. Chi CH, Rubio CA, Lagerlof B. The frequency and distribution of mitotic figures in dysplasia and carcinoma in situ. Cancer 1977;39:1218-1223.
11. Tanaka T. Proliferative activity in dysplasia, carcinoma in situ and microinvasive carcinoma of the uterine cervix. Pathol Res Pract 1986;181:531-539.
12. Mushika M, Miwa T, Suzuoki Y, et al. Detection of proliferative cells in dysplasia, carcinoma in situ, and invasive carcinoma of the uterine cervix by monoclonal antibody against DNA polymerase alpha. Cancer 1988;61:1182-1186.
13. Kobayashi I, Matsuo K, Ishibashi Y, et al. The proliferative activity in dysplasia and carcinoma in situ of the uterine cervix analyzed by proliferating cell nuclear antigen immunostaining and silver-binding argyrophilic nucleolar organizer region staining. Hum Pathol 1994;25:198-202.
14. Xue Y, Feng Y, Zhu G, et al. Proliferative activity in cervical intraepithelial neoplasia and cervical carcinoma. Chin Med J (Engl) 1999;112:373-375.
15. Popiolek D, Ventura K, Mittal K. Distinction of low-grade squamous intraepithelial lesions from high-grade squamous intraepithelial lesions based on quantitative analysis of proliferative activity. Oncol Rep 2004;11:687-691.
16. Van Leeuwen AM, Pieters WJ, Hollema H, et al. Atypical mitotic figures and the mitotic index in cervical intraepithelial neoplasia. Virchows Arch 1995;427:139-144.
17. Ward BE, Saleh AM, Williams JV, et al. Papillary immature metaplasia of the cervix: a distinct subset of exophytic cervical condyloma associated with HPV-6/11 nucleic acids. Mod Pathol 1992;5:391-395.
18. Egan AJ, Russell P. Transitional (urothelial) cell metaplasia of the uterine cervix: morphological assessment of 31 cases. Int J Gynecol Pathol 1997;16:89-98.
19. Weir MM, Bell DA, Young RH. Transitional cell metaplasia of the uterine cervix and vagina: an under-recognized lesion that may be confused with high-grade dysplasia. A report of 59 cases. Am J Surg Pathol 1997;21:510-517.
20. Gould SF, Shannon JM, Cunha GR. The autoradiographic demonstration of estrogen binding in normal human cervix and vagina during the menstrual cycle, pregnancy, and the menopause. Am J Anat 1983;168:229-238.
21. Scharl A, Vierbuchen M, Graupner J, et al. Immunohistochemical study of distribution of estrogen receptors in corpus and cervix uteri. Arch Gynecol Obstet 1988;241:221-233.
22. Ciocca DR, Puy LA, Lo Castro G. Localization of an estrogen-responsive protein in the human cervix during menstrual cycle, pregnancy, and menopause and in abnormal cervical epithelia without atypia. Am J Obstet Gynecol 1986;155:1090-1096.
23. Kanai M, Shiozawa T, Xin L, et al. Immunohistochemical detection of sex steroid receptors, cyclins, and cyclin-dependent kinases in the normal and neoplastic squamous epithelia of the uterine cervix. Cancer 1998;82:1709-1719.
24. Cano A, Serra V, Rivera J, et al. Expression of estrogen receptors, progesterone receptors, and an estrogen receptor-associated protein in the human cervix during the menstrual cycle and menopause. Fertil Steril 1990;54:1058-1064.
25. Mosny DS, Herholz J, Degen W, et al. Immunohistochemical investigations of steroid receptors in normal and neoplastic squamous epithelium of the uterine cervix. Gynecol Oncol 1989;35:373-377.
26. Remoue F, Jacobs N, Miot V, et al. High intraepithelial expression of estrogen and progesterone receptors in the transformation zone of the uterine cervix. Am J Obstet Gynecol 2003;189:1660-1665.
27. Kupryjanczyk J, Moller P. Estrogen receptor distribution in the normal and pathologically changed human cervix uteri: an immunohistochemical study with use of monoclonal anti-ER antibody. Int J Gynecol Pathol 1988;7:75-85.
28. Konishi I, Fujii S, Nonogaki H, et al. Imunohistochemical analysis of estrogen receptors, progestrone receptors, Ki-67 antigen, and human papillomavirus DNA in normal and neoplastic epithelium of the uterine cervix. Cancer 1991;68:1340-1350.
29. Scully RE, Bonfiglio TA, Kurman RJ, et al. Histological Typing of Female Genital Tract Tumours (International Histological Classification of Tumours), 2nd edn. Springer Verlag, 1994.
30. Kurman RJ, Norris HJ, Wilkinson E. Atlas of Tumor Pathology, 3rd series, Armed Forces Institute of Pathology: Fascicle Washington, DC, 1992.
31. Baak JR. Mitosis counting in tumors. Hum Pathol 1990;21:683-685.
32. Noyes RW, Hertig AT, Rock J. Dating the endometrial biopsy. Am J Obstet Gynecol 1975;122:262-263.
33. Pahuja S, Choudhury M, Gupta U. Ki-67 labelling as a proliferation marker in pre-invasive squamous epithelial lesions of cervix. Indian J Pathol Microbiol 2003;46:402-404.
34. Kalof AN, Cooper K. p16INK4a immunoexpression: surrogate marker of high-risk HPV and high-grade cervical intraepithelial neoplasia. Adv Anat Pathol 2006;13:190-194.
35. Richart RM. Cervical intraepithelial neoplasia. Pathol Annu 1973;8:301-328.
36. Arends MJ, Buckley CH, Wells M. Aetiology, pathogenesis, and pathology of cervical neoplasia. J Clin Pathol 1998;51:96-103.
37. Wells M, Ostor AG, Crum CP, et al. Epithelial tumours. In: Tavassoli FA, Devilee P (eds). World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. IARC Press: Lyon, 2003, pp 260-279.
38. Herrington CS. Human papillomaviruses and cervical neoplasia. II. Interaction of HPV with other factors. J Clin Pathol 1995;48:1-6.
39. Bosch FX, Lorincz A, Munoz N, et al. The causal relation between human papillomavirus and cervical cancer. J Clin Pathol 2002;55:244-265.
40. Stoler MH. Human papillomaviruses and cervical neoplasia: a model for carcinogenesis. Int J Gynecol Pathol 2000;19:16-28.
41. Evans MF, Cooper K. Human papillomavirus integration: detection by in situ hybridization and potential clinical application. J Pathol 2004;202:1-4.
42. Ostor AG. Natural history of cervical intraepithelial neoplasia: a critical review. Int J Gynecol Pathol 1993;12:186-192.