Hypoxia and antioxidants enhance soluble ICAM-1 release from cardiac fibroblasts

Molecular and Cellular Biochemistry

Volumn 303, Issue 1-2, 2007, Pages 259-262

  Sapna, S ^a   Shivakumar, K ^a  

^a SREE CHITRA TIRUNAL INSTITUTE FOR MEDICAL SCIENCES AND TECHNOLOGY   (India)

Author keywords

Cardiac fibroblasts; Hypoxia; N acetyl L cysteine; P42 44 MAPK; Protein kinase C; Pyrrolidine dithiocarbamate; SICAM 1

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; INTERCELLULAR ADHESION MOLECULE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE C; PYRROLIDINE DITHIOCARBAMATE;

ANIMAL CELL; ARTICLE; CELL SURFACE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; FIBROBLAST CULTURE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HYPOXIA; MALE; NONHUMAN; OXIDATION REDUCTION STATE; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUPERNATANT;

ACETYLCYSTEINE; ANIMALS; CELL HYPOXIA; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLASTS; FREE RADICAL SCAVENGERS; HEART VENTRICLES; INTERCELLULAR ADHESION MOLECULE-1; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

RATTUS;

EID: 34547921647     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-007-9475-9     Document Type: Article

References (16)

1. Tsakadze NL, Sithu SD, Sen U et al (2006) Tumor Necrosis Factor-α-converting enzyme (TACE/ADAM-17) mediates the ectodomain cleavage of intercellular adhesion molecule-1 (ICAM-1). J Biol Chem 281:3157-3164
2. Tsakadze NL, Sen U, Zhao Z et al (2004) Signals mediating cleavage of intercellular adhesion molecule-1. Am J Physiol Cell Physiol 287:C55-C63
3. Otto VI, Gloor SM, Frentzel S et al (2002) The production of macrophage inflammatory protein-2 induced by soluble intercellular adhesion molecule-1 in mouse astrocytes is mediated by src tyrosine kinases and p42/44 mitogen-activated protein kinase. J Neurochem 80:824-834
4. Gho YS, Kleinman HK, Sosne G (1999) Angiogenic activity of human soluble intercellular adhesion molecule-1. Cancer Res 59:5128-5132
5. Garton KJ, Gough PJ, Raines EW (2006) Emerging roles for ectodomain shedding in the regulation of inflammatory responses. J Leukoc Biol 79:1105-1116
6. Hwang SJ, Ballantyne CM, Sharrett AR et al (1997) Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: The atherosclerosis risk in communities (ARIC) study. Circulation 96:4219-4225
7. Miwa K, Igawa A, Inoue H (1997) Soluble E-selectin, ICAM-1 and VCAM-1 levels in systemic and coronary circulation in patients with variant angina. Cardiovasc Res 36:37-44
8. Niessen HWM, Krijnen PAJ, Visser CA et al (2002) Intercellular adhesion molecule-1 in the heart. Annals N Y Acad Sci 973:573-585
9. Blann AD, McCollum CN (1994) Circulating endothelial cell/leukocyte adhesion molecules in atherosclerosis. Thromb Haemost 72:151-154
10. Zund G, Uezono S, Stahl GL et al (1997) Hypoxia enhances induction of endothelial ICAM-1: Role for metabolic acidosis and proteasomes. Am J Physiol Cell Physiol 273:C1571-C1580
11. Kumaran C, Shivakumar K (2002) Calcium- and superoxide anion-mediated mitogenic action of substance P on cardiac fibroblasts. Am J Physiol Heart Circ Physiol 282:H1855-H1862
12. Brown RD, Ambler SK, Mitchell MD et al (2005) The cardiac fibroblast: therapeutic target in myocardial remodeling and failure. Ann Rev Pharmacol Toxicol 45:657-687
13. Kacimi R, Karliner JS, Koudssi F et al (1998) Expression and regulation of adhesion molecules in cardiac cells by cytokines. Circ Res 82:576-586
14. Walther M, Kaffenberger W, Van Beuningen D (1999) Influence of clinically used antioxidants on radiation-induced expression of intercellular cell adhesion molecule-1 on HUVEC. Int J Radiat Biol 75:1317-1325
15. Munoz C, Castellanos MC, Alfranca A et al (1996) Transcriptional up-regulation of Intracellular Adhesion Molecule-1 in human endothelial cells by the antioxidant Pyrrolidine Dithiocarbamate involves the activation of Activating Protein-1. J Immunol 157:3587-3597
16. Radomska-Lesniewska DM, Sadowska AM, Van Overveld FJ et al (2006) Influence of N-acetylcysteine on ICAM-1 expression and IL-8 release from endothelial and epithelial cells. J Physiol Pharmacol 57:325-334