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Synthetic studies by Xu's group:, and references therein
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Enantiomeric excess was determined by the modified Mosher ester analysis: Ohtani, I.; Kusumi, T.; Kashman, Y.; Kakisawa, H. J. Am. Chem. Soc. 1991, 113, 4092. For absolute configuration, see Supporting Information.
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Enantiomeric excess was determined by the modified Mosher ester analysis: Ohtani, I.; Kusumi, T.; Kashman, Y.; Kakisawa, H. J. Am. Chem. Soc. 1991, 113, 4092. For absolute configuration, see Supporting Information.
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16
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19
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34547914265
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Structure determination of 11a and 11b is in Supporting Information.
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Structure determination of 11a and 11b is in Supporting Information.
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21
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0002266884
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23
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34547911175
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The 4Z-isomer structure was determined by precise NMR analysis. See Supporting Information.
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The 4Z-isomer structure was determined by precise NMR analysis. See Supporting Information.
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24
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34547888476
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The starting materials were recovered (2: 39%, 15: 30%). The longer the reaction time, the lower the isolated yield due to partial decompositions. Other thermal conditions: in toluene, rt, 4 days, no reaction; in toluene, 60°C, 2.5 days, partial decomposition of 15; in 1,2-dichlorobenzene, 140°C, 1 day, decomposition of 2 and 15.
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The starting materials were recovered (2: 39%, 15: 30%). The longer the reaction time, the lower the isolated yield due to partial decompositions. Other thermal conditions: in toluene, rt, 4 days, no reaction; in toluene, 60°C, 2.5 days, partial decomposition of 15; in 1,2-dichlorobenzene, 140°C, 1 day, decomposition of 2 and 15.
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25
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3042745794
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Review for the enzymatic Diels-Alder reaction: Oikawa, H.; Tokiwano, T. Nat. Prod. Rep. 2004, 21, 321.
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Review for the enzymatic Diels-Alder reaction: Oikawa, H.; Tokiwano, T. Nat. Prod. Rep. 2004, 21, 321.
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