Development of a practical and reliable synthesis of laquinimod

Organic Process Research and Development

Volumn 11, Issue 4, 2007, Pages 674-680

  Wennerberg, Johan ^a   Björk, Anders ^b   Fristedt, Tomas ^b   Granquis, Bo ^a   Jansson, Karl ^b   Thuvesson, Ingela ^b  

^a DUPONT COMPANY   (United States)

^b Active Biotech Research AB   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 34547913770     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op700001c     Document Type: Article

References (14)

1. (a) Noseworthy, I. H.; Wolinsky, J. S.; Lublin, F. D. Neurology 2000, 54, 1726.
2. (b) Jönsson, S.; Andersson, G.; Fex, T.; Fristedt, T.; Hedlund, G.; Jansson, K.; Abramo, L.; Fritzon, I.; Pekarski, O.; Runström, A.; Sandin, H.; Thuvesson, I.; Björk, A. J. Med. Chem. 2004, 47, 2075.
3. (c) Björk, A.; Jönsson, S.; Fex, T.; Hedlund, G. U.S. Patent 6,077,851, 2000.
4. (a) Polman, C.; Barkhof, F.; Sandberg-Wolheim, M.; Linde, A.; Nordle, Ö.; Nederman, T. Neurology 2005, 64, 987.
5. (b) Jansson, K. U.S. Patent 6,875,869 B2, 2005.
6. (a) Eriksoo, E.; Sandberg, E. B.; Stålhandske, L. J. T. U.S. Patent 4,547,511, 1985.
7. (b) Sjovall, S.; Hansen, L.; Granquist, B. Org. Process Res. Dev. 2004, 8, 802.
8. Buckley, J.; Webb, R. L.; Laird, T.; Ward, R. J. Chem. Eng. News 1982, 60 (28), 5.
9. De Wall, G. Chem. Eng. News 1982, 60 (37), 5.
10. 3, see: Conlon, D. A.; Drahus-Paone, A.; Ho, G.-J.; Pipik, B.; Helmy, R.; McNamara, J. M.; Shi, Y.-J.; Williams, J. M.; McDonald, D.; Deschênes, D.; Gallant, M.; Mastracchio, A.; Roy, B.; Scheigetz, J. Org. Process Res. Dev. 2006, 10, 36.
11. Mosely, J. D.; Bansal, P.; Bowden, S. A.; Couch, A. E. M.; Hubacek, I.; Weingärtner, G. Org. Process Res. Dev. 2006, 10, 153.
12. Jansson, K.; Fristedt, T.; Olsson, A.; Svensson, B.; Jönsson, S. J. Org. Chem. 2006, 71, 1658.
13. Evolved chloromethane was absorbed in methanolic potassium hydroxide.
14. Bodanszky, M. Peptide Chemistry: A Practical Textbook; Springer: New York, 1988.