Relationship between plasma cholesterol, von Willebrand factor concentrations, extent of atherosclerosis and antibody titres to heat shock proteins-60, -65 and -70 in cholesterol-fed rabbits

International Journal of Experimental Pathology

Volumn 88, Issue 4, 2007, Pages 249-255

  Ghayour Mobarhan, Majid ^a,c   Lamb, David J ^a,d   Tavallaie, Shima ^c   Ferns, Gordon A A ^a,b  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b ROYAL SURREY COUNTY HOSPITAL   (United Kingdom)

^c MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

65 and 70; Cholesterol fed rabbit; Endothelium; Heat shock protein 60; vWF

Indexed keywords

ANTIBODY; CHOLESTEROL; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 65; HEAT SHOCK PROTEIN 70; VON WILLEBRAND FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ATHEROSCLEROSIS; BLOOD LEVEL; BLOOD SAMPLING; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MARKER; ENDOTHELIUM INJURY; ENZYME LINKED IMMUNOSORBENT ASSAY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; RABBIT;

ANIMALS; AORTA, THORACIC; AORTIC DISEASES; ARTERIOSCLEROSIS; AUTOANTIBODIES; BIOLOGICAL MARKERS; CHAPERONIN 60; CHOLESTEROL; CHOLESTEROL, DIETARY; DISEASE MODELS, ANIMAL; HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; RABBITS; VON WILLEBRAND FACTOR;

EID: 34547911390     PISSN: 09599673     EISSN: 13652613     Source Type: Journal    
DOI: 10.1111/j.1365-2613.2007.00542.x     Document Type: Conference Paper

References (26)

1. Boneu B., Abbal M., Plante J., Bierme R. (1975) Factor VIII complex and endothelial damage. Lancet 1, 1430.
2. Burian K., Kis Z., Virok D. et al. (2001) Independent and joint effects of antibodies to human heat-shock protein 60 and Chlamydia pneumoniae infection in the development of coronary atherosclerosis. Circulation 103, 1503 1508.
3. Cucuianu M.P., Cristea A., Roman S., Rus H., Missits I., Pechet L. (1983) Comparative behaviour of the components of the factor VIII complex in acute myocardial infarction. Thromb. Res. 30, 487 497.
4. De Meyer G.R.Y., Hoylaerts M.F., Kockx M.M., Yamamoto H., Herman A.G., Bult H. (1999) Intimal deposition of functional von Willebrand factor in atherogenesis. Arterioscler. Thromb. Vasc. Biol. 19, 2524 2534.
5. Ewenstein B.M. (1997) In: Vascular biology of von Willebrand factor. In: Vascular Endothelium, pp. 107 123 (ed. G.V.R. Born C.J. Schwartz Schattauer: Stuttgart.
6. Ghayour-Mobarhan M., Lamb D.J., Lovell D.P., Livingstone C., Wang T., Ferns G.A. (2005a) Plasma antibody titres to heat shock proteins-60, -65 and-70: their relationship to coronary risk factors in dyslipidaemic patients and healthy individuals. Scand. J. Clin. Lab. Invest. 65, 601 614.
7. Ghayour-Mobarhan M., New S.A., Lamb D.J. et al. (2005b) Dietary antioxidants and fat are associated with plasma antibody titers to heat shock proteins 60, 65, and 70 in subjects with dyslipidemia. Am. J. Clin. Nutr. 81, 998 1004.
8. Herz I., Rosso R., Roth A., Keren G., George J. (2006) Serum levels of anti heat shock protein 70 antibodies in patients with stable and unstable angina pectoris. Acute card. Care 8, 46 50.
9. Kahaleh M.B., Osborn I., LeRoy E.C. (1981) Increased factor VIII/von Willebrand factor antigen and von Willebrand factor activity in scleroderma and in Raynaud's phenomenon. Ann. Intern. Med. 94, 482 484.
10. Khan I.U., Wallin R., Gupta R.S., Kammer G.M. (1998) Protein kinase A-catalyzed phosphorylation of heat shock protein 60 chaperone regulates its attachment to histone 2B in the T lymphocyte plasma membrane. Proc. Natl. Acad. Sci. U.S.A. 95, 10425 10430.
11. Lamb D.J. Ferns G.A. (2002) The magnitude of the immune response to heat shock protein-65 following BCG immunisation is associated with the extent of experimental atherosclerosis. Atherosclerosis 165, 231 240.
12. Lamb D.J., Eales L.J., Ferns G.A. (1999) Immunization with bacillus Calmette-Guerin vaccine increases aortic atherosclerosis in the cholesterol-fed rabbit. Atherosclerosis 143, 105 113.
13. Lamb D.J., El Sankary W., Ferns G.A. (2003) Molecular mimicry in atherosclerosis: a role for heat shock proteins in immunisation. Atherosclerosis 167, 177 185.
14. Mannucci P.M. (1998) von Willebrand factor: a marker of endothelial damage? Arterioscler. Thromb. Vasc. Biol. 18, 1359 1362.
15. Morimoto R.I. (1993) Cells in stress: transcriptional activation of heat shock genes. Science 259, 1409 1410.
16. Newsholme S.J., Thudlum D.T., Gossett K.A., Watson E.S., Schwartz L.W. (2000) Evaluation of plasma von Willebrand factor as a biomarker for acute arterial damage in rats. Toxicol. Pathol. 28, 688 693.
17. Pockley A.G., Georgiades A., Thulin T., de Faire U., Frostegard J. (2003) Serum heat shock protein 70 levelspredict the development of atherosclerosis in subject with established hypertension. Hypertension 42, 235 238.
18. Ross R. (1999) Atherosclerosis-an inflammatory disease. N. Engl. J. Med. 340, 115 126.
19. Rutherford C., Martin W., Carrier M., Anggard E.E., Ferns G.A. (1997) Endogenously elicited antibodies to platelet derived growth factor-BB and platelet cytosolic protein inhibit aortic lesion development in the cholesterol-fed rabbit. Int. J. Exp. Pathol. 78, 21 32.
20. Stehouwer C.D.A., Fischer H.R.A., van Kuijk A.W.R., Polak B.C.P., Donker A.J.M. (1995) Endothelial dysfunction precedes development of microlbuminuria in IDDM. Diabetes 44, 561 564.
21. Udelsman R., Blake M.J., Stagg C.A., Li D.G., Putney D.J., Holbrook N.J. (1993) Vascular heat shock protein expression in response to stress. Endocrine and autonomic regulation of this age-dependent response. J. Clin. Invest. 91, 465 473.
22. Veres A., Fust G., Smieja M. et al. (2002) Relation ship of anti-60 kDa heat shock protein and anti-cholesterol antibodies to cardiovascular events. Circulation 106, 2775 2780.
23. Wojakowski W. Gminski J. (2001) Plasma levels of von Willebrand factor, endothelin, endothelin-1 prostacyclin and thromboxane in children from families with high risk of premature artery disease. Scand. J. Clin. Lab. Invest. 61, 317 323.
24. Xu Q., Willeit J., Marosi M. et al. (1993) Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis. Lancet 341, 255 259.
25. Xu Q., Kiechl S., Mayr M. et al. (1999) Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis: clinical significance determined in a follow-up study. Circulation 100, 1169 1174.
26. Zhu J.H., Quyyumi A.A., Rott D. et al. (2001) Antibodies to human heat-shock protein 60 are associated with the presence and severity of coronary artery disease: evidence for an autoimmune component of atherogensis. Circulation 103, 1071 1075.