Neuroprotection with or without erythropoiesis; sometimes less is more

British Journal of Pharmacology

Volumn 151, Issue 8, 2007, Pages 1141-1142

  Torup, L ^a  

^a H LUNDBECK A S   (Denmark)

Author keywords

CEPO; EPO; MCAO; Stroke

Indexed keywords

CARBAMYLATED ERYTHROPOIETIN; ERYTHROPOIETIN; RECOMBINANT ERYTHROPOIETIN; UNCLASSIFIED DRUG;

ANEMIA; DRUG EFFECT; DRUG EFFICACY; ERYTHROPOIESIS; HEMATOCRIT; HEMATOLOGICAL PARAMETERS; HEMATOLOGY; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; CEREBROVASCULAR ACCIDENT; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROPOIETIN; HEMATOCRIT; NEUROPROTECTIVE AGENTS; RATS;

EID: 34547907376     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707287     Document Type: Review

References (18)

1. Brines ML, Ghezzi P, Keenan S, Agnello D, de Lanerolle NC, Cerami C et al. (2000). Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc Natl Acad Sci USA 97: 10526-10531.
2. Coull AJ, Rothwell PM (2004). Underestimation of the early risk of recurrent stroke: evidence of the need for a standard definition. Stroke 35: 1925-1929.
3. Digicaylioglu M, Bichet S, Marti HH, Wenger RH, Rivas LA, Bauer C et al. (1995). Localization of specific erythropoietin binding sites in defined areas of the mouse brain. Proc Natl Acad Sci USA 92: 3717-3720.
4. Ehrenreich H, Hasselblatt M, Dembowski C, Cepek L, Lewczuk P, Stiefel M et al. (2002). Erythropoietin therapy for acute stroke is both safe and beneficial. Mol Med 8: 495-505.
5. Leist M, Ghezzi P, Grasso G, Bianchi R, Villa P, Fratelli M et al. (2004). Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science 305: 239-242.
6. Lu D, Mahmood A, Qu C, Goussev A, Schallert T, Chopp M (2005). Erythropoietin enhances neurogenesis and restores spatial memory in rats after traumatic brain injury. J Neurotrauma 22: 1011-1017.
7. Masuda S, Nagao M, Takahata K, Konishi Y, Gallyas Jr F, Tabira T et al. (1993). Functional erythropoietin receptor of the cells with neural characteristics Comparison with receptor properties of erythroid cells. J Biol Chem 268: 11208-11216.
8. Masuda S, Okano M, Yamagishi K, Nagao M, Ueda M, Sasaki R (1994). A novel site of erythropoietin production Oxygen-dependent production in cultured rat astrocytes. J Biol Chem 269: 19488-19493.
9. Morishita E, Masuda S, Nagao M, Yasuda Y, Sasaki R (1996). Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death. Neuroscience 76: 105-116.
10. Rosenzweig M, Bender C, Lucke J, Yasko J, Brufsky A (2004). The decision to prematurely terminate a trial of R-HuEPO due to thrombotic events. J Pain Symptom Manage 27: 185-190.
11. Sakanaka M, Wen TC, Matsuda S, Masuda S, Morishita E, Nagao M et al. (1998). In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc Natl Acad Sci USA 95: 4635-4640.
12. Siren AL, Fratelli M, Brines M, Goemans C, Casagrande S, Lewczuk P et al. (2001). Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Natl Acad Sci USA 98: 4044-4049.
13. Tsai PT, Ohab JJ, Kertesz N, Groszer M, Matter C, Gao J et al. (2006). A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci 26: 1269-1274.
14. Villa P, Bigini P, Mennini T, Agnello D, Laragione T, Cagnotto A et al. (2003). Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis. J Exp Med 198: 971-975.
15. Villa P, Van Beek J, Larsen A, Gerwien J, Christensen S, Cerami A et al. (2007). Reduced functional deficits, neuroinflammation, and secondary tissue damage after treatment of stroke by non-erythropoietic erythropoietin derivatives. J Cereb Blood Flow Metab 27: 552-563.
16. Wang L, Zhang Z, Gregg SR, Zhang R, Jiao Z, Le Tourneau Y et al. (2007a). The Sonic Hedgehog Pathway Mediates Carbamylated EPO Enhanced Proliferation and Differentiation of Adult Neural Progenitor Cells. International Stroke Conference Abstract.
17. Wang L, Zhang Z, Wang Y, Zhang R, Chopp M (2004). Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats. Stroke 35: 1732-1737.
18. Wang Y, Zhang Z, Rhodes K, Renzi M, Zhang RL, Kapke A et al. (2007b). Postischemic treatment with erythropoietin or carbamylated erythropoietin reduces infarction and improves neurological outcome in a rat model of focal cerebral ischemia. Br J Pharmacol 151: 1377-1384 (this issue).