Impaired cutaneous wound healing in granulocyte/macrophage colony-stimulating factor knockout mice

British Journal of Dermatology

Volumn 157, Issue 3, 2007, Pages 458-465

  Fang, Y ^a   Gong, S J ^a   Xu, Y H ^b   Hambly, B D ^b   Bao, S ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Cytokine; Granulocyte macrophage colony stimulating factor; Wound healing

Indexed keywords

CD31 ANTIGEN; COLONY STIMULATING FACTOR 1; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN INJURY; VASCULARIZATION; WILD TYPE; WOUND CLOSURE; WOUND HEALING IMPAIRMENT;

ANIMALS; CYTOKINES; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; KERATINOCYTES; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SKIN; WOUND HEALING;

EID: 34547904651     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2007.07979.x     Document Type: Article

References (29)

1. Martin P. Wound healing - aiming for perfect skin regeneration. Science 1997 276 : 75 81.
2. Clark RAF. Overview and general considerations. In : The Molecular and Cellular Biology of Wound Repair (Clark RAF, ed 2nd edn. New York : Plenum Press, 1996 1 30.
3. Diegelmann RF, Evans MC. Wound healing: an overview of acute, fibrotic and delayed healing. Front Biosci 2004 9 : 283 9.
4. Crosier PS, Garnick MB, Clark SC. Granulocyte-macrophage colony-stimulating factor. In : Human Cytokines: Handbook for Basic and Clinical Research (Aggarwal BB, Gutterman JU, eds). Boston : Blackwell Publishing, 1998.
5. Middleton M, Thatcher N. G- and GM-CSF. Int J Antimicrob Agents 1998 10 : 91 3.
6. Imokawa G, Yada Y, Kimura M et al. Granulocyte/macrophage colony-stimulating factor is an intrinsic keratinocyte-derived growth factor for human melanocytes in UVA-induced melanosis. Biochem J 1996 313 : 625 31.
7. Bussolino F, Wang JM, Defilippi P et al. Granulocyte- and granulocyte-macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate. Nature 1989 337 : 471 3.
8. Hancock GE, Kaplan G, Cohn ZA. Keratinocyte growth regulation by the products of immune cells. J Exp Med 1988 168 : 1395 402.
9. Kawada A, Hiruma M, Noguchi H et al. Granulocyte and macrophage colony-stimulating factors stimulate proliferation of human keratinocytes. Arch Dermatol Res 1997 289 : 600 2.
10. Stagno F, Guglielmo P, Consoli U et al. Successful healing of hydroxyurea-related leg ulcers with topical granulocyte-macrophage colony-stimulating factor. Blood 1999 94 : 1479 80.
11. Da Costa RM, Ribeiro Jesus FM, Aniceto C et al. Randomized, double-blind, placebo-controlled, dose-ranging study of granulocyte-macrophage colony stimulating factor in patients with chronic venous leg ulcers. Wound Repair Regen 1999 7 : 17 25.
12. Voskaridou E, Kyrtsonis MC, Loutradi-Anagnostou A. Healing of chronic leg ulcers in the hemoglobinopathies with perilesional injections of granulocyte-macrophage colony-stimulating factor. Blood 1999 93 : 3568 9.
13. Braunstein S, Kaplan G, Gottlieb AB et al. GM-CSF activates regenerative epidermal growth and stimulates keratinocyte proliferation in human skin in vivo. J Invest Dermatol 1994 103 : 601 4.
14. Kaplan G, Walsh G, Guido LS et al. Novel responses of human skin to intradermal recombinant granulocyte/macrophage-colony-stimulating factor: Langerhans cell recruitment, keratinocyte growth, and enhanced wound healing. J Exp Med 1992 175 : 1717 28.
15. Jyung RW, Mustoe JA, Busby WH et al. Increased wound-breaking strength induced by insulin-like growth factor I in combination with insulin-like growth factor binding protein-1. Surgery 1994 115 : 233 9.
16. Jyung RW, Wu L, Pierce GF et al. Granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor: differential action on incisional wound healing. Surgery 1994 115 : 325 34.
17. Xing Z, Gauldie J, Tremblay GM et al. Intradermal transgenic expression of granulocyte-macrophage colony-stimulating factor induces neutrophilia, epidermal hyperplasia, Langerhans' cell/macrophage accumulation, and dermal fibrosis. Lab Invest 1997 77 : 615 22.
18. Ure I, Partsch B, Wolff K et al. Granulocyte/macrophage colony-stimulating factor increases wound-fluid interleukin 8 in normal subjects but does not accelerate wound healing. Br J Dermatol 1998 138 : 277 82.
19. Mann A, Breuhahn K, Schirmacher P et al. Keratinocyte-derived granulocyte-macrophage colony stimulating factor accelerates wound healing: stimulation of keratinocyte proliferation, granulation tissue formation, and vascularization. J Invest Dermatol 2001 117 : 1382 90.
20. Seymour JF, Lieschke GJ, Grail D et al. Mice lacking both granulocyte colony-stimulating factor (CSF) and granulocyte-macrophage CSF have impaired reproductive capacity, perturbed neonatal granulopoiesis, lung disease, amyloidosis, and reduced long-term survival. Blood 1997 90 : 3037 49.
21. Bao S, Beagley KW, France MP et al. Interferon-gamma plays a critical role in intestinal immunity against Salmonella typhimurium infection. Immunology 2000 99 : 464 72.
22. Shen J, Bao S, Reeve VE. Modulation of IL-10, IL-12, and IFN-gamma in the epidermis of hairless mice by UVA (320-400 nm) and UVB (280-320 nm) radiation. J Invest Dermatol 1999 113 : 1059 64.
23. Breuhahn K, Mann A, Muller G et al. Epidermal overexpression of granulocyte-macrophage colony-stimulating factor induces both keratinocyte proliferation and apoptosis. Cell Growth Differ 2000 11 : 111 21.
24. Gillitzer R, Goebeler M. Chemokines in cutaneous wound healing. J Leukoc Biol 2001 69 : 513 21.
25. Perales MA, Fantuzzi G, Goldberg SM et al. GM-CSF DNA induces specific patterns of cytokines and chemokines in the skin: implications for DNA vaccines. Cytokines Cell Mol Ther 2002 7 : 125 33.
26. Rollwagen FM, Davis TA, Li YY et al. Orally administered IL-6 induces elevated intestinal GM-CSF gene expression and splenic CFU-GM. Cytokine 2004 27 : 107 12.
27. Kishimoto T, Akira S, Taga T. Interleukin-6 and its receptor: a paradigm for cytokines. Science 1992 258 : 593 7.
28. Akira S, Kishimoto T. IL-6 and NF-IL6 in acute-phase response and viral infection. Immunol Rev 1992 127 : 25 50.
29. Lin ZQ, Kondo T, Ishida Y et al. Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice. J Leukoc Biol 2003 73 : 713 21.