Keratinocyte-derived granulocyte-macrophage colony stimulating factor accelerates wound healing: Stimulation of keratinocyte proliferation, granulation tissue formation, and vascularization

Journal of Investigative Dermatology

Volumn 117, Issue 6, 2001, Pages 1382-1390

  Mann, Amrit ^a   Breuhahn, Kai ^a,b   Schirmacher, Peter ^b   Blessing, Manfred ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

GM CSF; Skin; Transgenic mice; Wound healing

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; EPIDERMIS; EPITHELIZATION; EXCISION; GRANULATION TISSUE; KERATINOCYTE; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SKIN; TRANSGENIC MOUSE; VASCULARIZATION; WOUND HEALING;

EID: 0035677890     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-202x.2001.01600.x     Document Type: Article

References (57)

1. Leaper DJ: Proteinases, their inhibitors, and cytokine profiles in acute wound fluid
2. Transforming growth factor beta in tissue fibrosis
3. Granulocyte macrophage colony-stimulating factor contributes to enhanced monocyte survival in chronic atopic dermatitis
4. GM-CSF activates regenerative epidermal growth and stimulates keratinocyte proliferation in human skin in vivo
5. Overexpression of GM-CSF in the epidermis of transgenic mice induces both keratinocyte proliferation and apoptosis
6. Granulocyte- and granulocyte-macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate
7. In vitro and in vivo activation of endothelial cells by colony-stimulating factors
8. GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells
9. CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha
10. Cutaneous tissue repair: Basic biologic considerations. I
11. Randomized, double-blind, placebo-controlled, dose-ranging study of granulocyte-macrophage colony stimulating factor in patients with chronic venous leg ulcers
12. Human granulocyte-macrophage colony-stimulating factor is a growth factor active on a variety of cell types of nonhemopoietic origin
13. Pressure ulcer accelerated healing with local injections of granulocyte macrophage-colony stimulating factor
14. Transforming growth factors beta1, beta 2, and beta3 and their receptors are differentially regulated during normal and impaired wound healing
15. Digital necroses and Sharp's syndrome: The success of topical application of granulocyte/macrophage-colony stimulating factor in promoting healing after amputation of three toes
16. Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice
17. Gene expression and production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils
18. Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion
19. Keratinocyte growth regulation by the products of immune cells
20. Recombinant human granulocyte-macrophage colony-stimulating factor applied locally in low doses enhances healing and prevents recurrence of chronic venous ulcers
21. The effects of rhGM-CSF on macrophage function
22. Increased wound-breaking strength induced by insulin-like growth factor I in combination with insulin-like growth factor binding protein-1
23. Granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor: Differential action on incisional wound healing
24. Recent advances in cytokine therapy in leprosy
25. Novel responses of human skin to intradermal recombinant granulocyte/macrophage-colony-stimulating factor: Langerhans cell recruitment, keratinocyte growth, and enhanced wound healing
26. Granulocyte and macrophage colony-stimulating factors stimulate proliferation of human keratinocytes
27. Immunological effects of BCG as an adjuvant in autologous tumor vaccines
28. Up- and downregulation of granulocyte-macrophage colony-stimulating factor activity in murine skin increase susceptibility to skin carcinogenesis by independent mechanisms
29. Wound healing - Aiming for perfect skin regeneration
30. TGF-beta regulation of epithelial cell proliferation
31. TGF-beta stimulation and inhibition of cell proliferation: New mechanistic insights
32. Growth factor-induced acceleration of tissue repair through direct and inductive activities in a rabbit dermal ulcer model
33. Correlation between interleukin-6 and matrix metalloproteinase-9 in early wound healing in children
34. Interleukin-6 and the skin
35. Growth related secretion and production of GM-CSF by epithelial cell line
36. Granulocyte macrophage colony-stimulating factor is overproduced by keratinocytes in atopic dermatitis. Implications for sustained dendritic cell activation in the skin
37. Transforming growth factor-beta stimulates wound healing and modulates extracellular matrix gene expression in pig skin. I. Excisional wound model
38. Transforming growth factor-beta stimulates wound healing and modulates extracellular matrix gene expression in pig skin: Incisional wound model
39. Granulocyte-macrophage colony-stimulating factor mRNA stabilization enhances transgenic expression in normal cells and tissues
40. Becaplermin gel in the treatment of pressure ulcers: A phase II randomized, double-blind, placebo-controlled study
41. Granulocyte-macrophage colony stimulating factor gene expression and function during tumor promotion
42. Granulocyte-macrophage colony-stimulating factor: Pleiotropic cytokine with potential clinical usefulness
43. Transforming growth factor-beta 1 up-regulates type IV collagenase expression in cultured human keratinocytes
44. Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis
45. TGF-beta s and TGF-beta type II receptor in human epidermis: Differential expression in acute and chronic skin wounds
46. Successful healing of hydroxyurea-related leg ulcers with topical granulocyte-macrophage colony-stimulating factor
47. Granulocyte/macrophage colony-stimulating factor increases wound-fluid interleukin 8 in normal subjects but does not accelerate wound healing
48. A complex element regulates IFN-gamma-stimulated monocyte chemoattractant protein-1 gene transcription
49. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is expressed in mouse skin in response to tumor-promoting agents and modulates dermal inflammation and epidermal dark cell numbers
50. Healing of chronic leg ulcers in the hemoglobinopathies with perilesional injections of granulocyte-macrophage colony-stimulating factor
51. Control of type II transforming growth factor-beta receptor expression by integrin ligation [In Process Citation]
52. Transgenic studies with a keratin promoter-driven growth hormone transgene: Prospects for gene therapy
53. 12-O-tetradecanoylphorbol-13-acetate promotion of transgenic mouse epidermis coexpressing transforming growth factor-alpha and v-fos: Acceleration of autonomous papilloma formation and malignant conversion via c-Ha-ras activation
54. Gene transfer for cytokine functional studies in the lung: The multifunctional role of GM-CSF in pulmonary inflammation
55. Intradermal transgenic expression of granulocyte-macrophage colony-stimulating factor induces neutrophilia, epidermal hyperplasia, Langerhans' cell/macrophage accumulation, and dermal fibrosis
56. Overexpression of granulocyte-macrophage colony-stimulating factor induces pulmonary granulation tissue formation and fibrosis by induction of transforming growth factor-beta 1 and myofibroblast accumulation