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Volumn 51, Issue 4, 2007, Pages 511-519

Growth hormone (GH) and IGF-I assays: Methodological aspects and its implications in acromegaly diagnosis and follow-up;Ensaios para a medida de hormônio do crescimento (GH) e IGF-I: Aspectos metodológicos e suas implicações no diagnóstico e seguimento da acromegalia

Author keywords

Acromegaly; Diagnosis; Growth hormone; Immunoassays

Indexed keywords


EID: 34547903604     PISSN: 00042730     EISSN: 16779487     Source Type: Journal    
DOI: 10.1590/s0004-27302007000400003     Document Type: Review
Times cited : (2)

References (50)
  • 1
    • 0023251850 scopus 로고
    • Circulating molecular variants of growth hormone in childhood
    • Baumann G, Winter RJ, Shaw M. Circulating molecular variants of growth hormone in childhood. Pediatr Res 1987;22:21-2.
    • (1987) Pediatr Res , vol.22 , pp. 21-22
    • Baumann, G.1    Winter, R.J.2    Shaw, M.3
  • 2
    • 0033818789 scopus 로고    scopus 로고
    • Growth hormone (GH), GH receptor, and signal transduction
    • Kopchick JJ, Andry JM. Growth hormone (GH), GH receptor, and signal transduction. Mol Genet Metab 2000;71:293-314.
    • (2000) Mol Genet Metab , vol.71 , pp. 293-314
    • Kopchick, J.J.1    Andry, J.M.2
  • 3
    • 0032997336 scopus 로고    scopus 로고
    • Growth hormone heterogeneity in human pituitary and plasma
    • Baumann G. Growth hormone heterogeneity in human pituitary and plasma. Horm Res 1999;51(suppl. 1):2-6.
    • (1999) Horm Res , vol.51 , Issue.SUPPL. 1 , pp. 2-6
    • Baumann, G.1
  • 4
    • 0025999498 scopus 로고
    • Growth hormone heterogeneity: Genes, isohormones, variants, and binding proteins
    • Baumann G. Growth hormone heterogeneity: genes, isohormones, variants, and binding proteins. Endocr Rev 1991;12:424-49.
    • (1991) Endocr Rev , vol.12 , pp. 424-449
    • Baumann, G.1
  • 5
    • 0034856622 scopus 로고    scopus 로고
    • Growth hormone: Its measurement and the need for assay harmonization
    • Wood P. Growth hormone: its measurement and the need for assay harmonization. Ann Clin Biochem 2001;38:471-82.
    • (2001) Ann Clin Biochem , vol.38 , pp. 471-482
    • Wood, P.1
  • 6
    • 0033001755 scopus 로고    scopus 로고
    • Serum growth hormone measurements in clinical practice: An audit of performance from the UK National External Quality Assessment scheme
    • Seth J, Ellis A, Al-Sadie R. Serum growth hormone measurements in clinical practice: An audit of performance from the UK National External Quality Assessment scheme. Horm Res 1999;51(suppl. 1):13-9.
    • (1999) Horm Res , vol.51 , Issue.SUPPL. 1 , pp. 13-19
    • Seth, J.1    Ellis, A.2    Al-Sadie, R.3
  • 7
    • 0030926571 scopus 로고    scopus 로고
    • Growth hormone (GH) assays: Influence of standard preparations, GH isoforms, assay characteristics, and GH-binding protein
    • Jansson C, Boguszewski C, Rosberg S, Carlsson L, Albertsson-Wikland K. Growth hormone (GH) assays: influence of standard preparations, GH isoforms, assay characteristics, and GH-binding protein. Clin Chem 1997;43:950-6.
    • (1997) Clin Chem , vol.43 , pp. 950-956
    • Jansson, C.1    Boguszewski, C.2    Rosberg, S.3    Carlsson, L.4    Albertsson-Wikland, K.5
  • 8
    • 0023930989 scopus 로고
    • The circulating growth hormone (GH)-binding protein complex: A major constituent of plasma GH in man
    • Baumann G, Amburn K, Shaw MA. The circulating growth hormone (GH)-binding protein complex: a major constituent of plasma GH in man. Endocrinology 1988;122:976-84.
    • (1988) Endocrinology , vol.122 , pp. 976-984
    • Baumann, G.1    Amburn, K.2    Shaw, M.A.3
  • 9
    • 0025913941 scopus 로고
    • Plasma growth hormone (GH)-binding proteins: Effect on GH binding to receptors and GH action
    • Mannor DA, Winer LM, Shaw MA, Baumann G. Plasma growth hormone (GH)-binding proteins: effect on GH binding to receptors and GH action. J Clin Endocrinol Metab 1991;73:30-4.
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 30-34
    • Mannor, D.A.1    Winer, L.M.2    Shaw, M.A.3    Baumann, G.4
  • 10
    • 0028980496 scopus 로고
    • Identification of transformed alpha 2-macroglobulin as a growth hormone-binding protein in human blood
    • Kratzsch J, Selisko T, Birkenmeier G. Identification of transformed alpha 2-macroglobulin as a growth hormone-binding protein in human blood. J Clin Endocrinol Metab 1995;80:585-90.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 585-590
    • Kratzsch, J.1    Selisko, T.2    Birkenmeier, G.3
  • 11
    • 0022625025 scopus 로고
    • Molecular forms of human growth hormone secreted in vivo: Nonspecificity of secretory stimuli
    • Baumann G, Stolar MW. Molecular forms of human growth hormone secreted in vivo: nonspecificity of secretory stimuli. J Clin Endocrinol Metab 1986;62:789-90.
    • (1986) J Clin Endocrinol Metab , vol.62 , pp. 789-790
    • Baumann, G.1    Stolar, M.W.2
  • 12
    • 0037162458 scopus 로고    scopus 로고
    • Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis
    • Gent J, van Kerkhof P, Roza M, Bu G, Strous GJ. Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis. Proc Natl Acad Sci USA 2002;99:9858-63.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 9858-9863
    • Gent, J.1    van Kerkhof, P.2    Roza, M.3    Bu, G.4    Strous, G.J.5
  • 15
    • 0029838996 scopus 로고    scopus 로고
    • The regulation of growth hormone secretion
    • Cuttler L. The regulation of growth hormone secretion. Endocrinol Metab Clin North Am 1996;25:541-71.
    • (1996) Endocrinol Metab Clin North Am , vol.25 , pp. 541-571
    • Cuttler, L.1
  • 16
    • 33747360669 scopus 로고    scopus 로고
    • Novel mechanisms of growth hormone regulation: Growth hormone-releasing peptides and ghrelin
    • Lengyel AM. Novel mechanisms of growth hormone regulation: growth hormone-releasing peptides and ghrelin. Braz J Med Biol Res 2006;39:1003-11.
    • (2006) Braz J Med Biol Res , vol.39 , pp. 1003-1011
    • Lengyel, A.M.1
  • 18
    • 0033001585 scopus 로고    scopus 로고
    • International standards for growth hormone
    • Bristow AF. International standards for growth hormone. Horm Res 1999;51(suppl. 1):7-12.
    • (1999) Horm Res , vol.51 , Issue.SUPPL. 1 , pp. 7-12
    • Bristow, A.F.1
  • 19
    • 0037866478 scopus 로고    scopus 로고
    • Molecular heterogeneity of human GH: From basic research to clinical implications
    • Boguszewski CL. Molecular heterogeneity of human GH: from basic research to clinical implications. J Endocrinol Invest 2003;26:274-88.
    • (2003) J Endocrinol Invest , vol.26 , pp. 274-288
    • Boguszewski, C.L.1
  • 20
    • 0014412939 scopus 로고
    • Labelled antibodies and immunological assay systems
    • Miles LE, Hales CN. Labelled antibodies and immunological assay systems. Nature 1968;219:186-9.
    • (1968) Nature , vol.219 , pp. 186-189
    • Miles, L.E.1    Hales, C.N.2
  • 21
    • 0024595635 scopus 로고
    • Variability in the quantitation of circulating growth hormone using commercial immunoassays
    • Celniker AC, Chen AB, Wert RM, Jr., Sherman BM. Variability in the quantitation of circulating growth hormone using commercial immunoassays. J Clin Endocrinol Metab 1989;68:469-76.
    • (1989) J Clin Endocrinol Metab , vol.68 , pp. 469-476
    • Celniker, A.C.1    Chen, A.B.2    Wert Jr., R.M.3    Sherman, B.M.4
  • 22
    • 0036312912 scopus 로고    scopus 로고
    • Assessment of disease activity in treated acromegalic patients using a sensitive GH assay: Should we achieve strict normal GH levels for a biochemical cure?
    • Costa AC, Rossi A, Martinelli CE, Jr., Machado HR, Moreira AC. Assessment of disease activity in treated acromegalic patients using a sensitive GH assay: should we achieve strict normal GH levels for a biochemical cure? J Clin Endocrinol Metab 2002;87:3142-7.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3142-3147
    • Costa, A.C.1    Rossi, A.2    Martinelli Jr., C.E.3    Machado, H.R.4    Moreira, A.C.5
  • 24
    • 0742324440 scopus 로고    scopus 로고
    • Pitfalls in the biochemical assessment of acromegaly
    • Freda PU. Pitfalls in the biochemical assessment of acromegaly. Pituitary 2003;6:135-40.
    • (2003) Pituitary , vol.6 , pp. 135-140
    • Freda, P.U.1
  • 25
    • 0031763448 scopus 로고    scopus 로고
    • Evaluation of disease status with sensitive measures of growth hormone secretion in 60 postoperative patients with acromegaly
    • Freda PU, Post KD, Powell JS, Wardlaw SL. Evaluation of disease status with sensitive measures of growth hormone secretion in 60 postoperative patients with acromegaly. J Clin Endocrinol Metab 1998;83:3808-16.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 3808-3816
    • Freda, P.U.1    Post, K.D.2    Powell, J.S.3    Wardlaw, S.L.4
  • 27
    • 0021080158 scopus 로고
    • Use of a two-site immunoradiometric assay for growth hormone (GH) in identifying children with GH-dependent growth failure
    • Blethen SL, Chasalow FI. Use of a two-site immunoradiometric assay for growth hormone (GH) in identifying children with GH-dependent growth failure. J Clin Endocrinol Metab 1983;57:1031-5.
    • (1983) J Clin Endocrinol Metab , vol.57 , pp. 1031-1035
    • Blethen, S.L.1    Chasalow, F.I.2
  • 28
    • 0023837137 scopus 로고
    • Variable estimates of serum growth hormone concentrations by different radioassay systems
    • Reiter EO, Morris AH, MacGillivray MH, Weber D. Variable estimates of serum growth hormone concentrations by different radioassay systems. J Clin Endocrinol Metab 1988;66:68-71.
    • (1988) J Clin Endocrinol Metab , vol.66 , pp. 68-71
    • Reiter, E.O.1    Morris, A.H.2    MacGillivray, M.H.3    Weber, D.4
  • 29
    • 2542525315 scopus 로고    scopus 로고
    • Biochemical markers of acromegaly: GH vs. IGF-I
    • Barkan AL. Biochemical markers of acromegaly: GH vs. IGF-I. Growth Horm IGF Res 2004;14(suppl. A):S97-100.
    • (2004) Growth Horm IGF Res , vol.14 , Issue.SUPPL. A
    • Barkan, A.L.1
  • 30
    • 0028270653 scopus 로고
    • Enhanced sensitivity growth hormone (GH) chemiluminescence assay reveals lower postglucose nadir GH concentrations in men than women
    • Chapman IM, Hartman ML, Straume M, Johnson ML, Veldhuis JD, Thorner MO. Enhanced sensitivity growth hormone (GH) chemiluminescence assay reveals lower postglucose nadir GH concentrations in men than women. J Clin Endocrinol Metab 1994;78:1312-9.
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 1312-1319
    • Chapman, I.M.1    Hartman, M.L.2    Straume, M.3    Johnson, M.L.4    Veldhuis, J.D.5    Thorner, M.O.6
  • 31
    • 0346732359 scopus 로고    scopus 로고
    • Seeking the optimal target range for insulin-like growth factor I during the treatment of adult growth hormone disorders
    • Mukherjee A, Monson JP, Jonsson PJ, Trainer PJ, Shalet SM. Seeking the optimal target range for insulin-like growth factor I during the treatment of adult growth hormone disorders. J Clin Endocrinol Metab 2003;88:5865-70.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 5865-5870
    • Mukherjee, A.1    Monson, J.P.2    Jonsson, P.J.3    Trainer, P.J.4    Shalet, S.M.5
  • 32
    • 0042384687 scopus 로고    scopus 로고
    • Transsphenoidal surgery for acromegaly in Wales: Results based on stringent criteria of remission
    • De P, Rees DA, Davies N, John R, Neal J, Mills RG, et al. Transsphenoidal surgery for acromegaly in Wales: results based on stringent criteria of remission. J Clin Endocrinol Metab 2003;88:3567-72.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3567-3572
    • De, P.1    Rees, D.A.2    Davies, N.3    John, R.4    Neal, J.5    Mills, R.G.6
  • 33
    • 1442327778 scopus 로고    scopus 로고
    • Long-term biochemical status and disease-related morbidity in 53 postoperative patients with acromegaly
    • Serri O, Beauregard C, Hardy J. Long-term biochemical status and disease-related morbidity in 53 postoperative patients with acromegaly. J Clin Endocrinol Metab 2004;89:658-61.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 658-661
    • Serri, O.1    Beauregard, C.2    Hardy, J.3
  • 34
    • 1942473114 scopus 로고    scopus 로고
    • Growth hormone and pituitary radiotherapy, but not serum insulin-like growth factor-I concentrations, predict excess mortality in patients with acromegaly
    • Ayuk J, Clayton RN, Holder G, Sheppard MC, Stewart PM, Bates AS. Growth hormone and pituitary radiotherapy, but not serum insulin-like growth factor-I concentrations, predict excess mortality in patients with acromegaly. Clin Endocrinol Metab 2004;89:1613-7.
    • (2004) Clin Endocrinol Metab , vol.89 , pp. 1613-1617
    • Ayuk, J.1    Clayton, R.N.2    Holder, G.3    Sheppard, M.C.4    Stewart, P.M.5    Bates, A.S.6
  • 36
    • 33746067188 scopus 로고    scopus 로고
    • Age changes the diagnostic accuracy of mean profile and nadir growth hormone levels after oral glucose in postoperative patients with acromegaly
    • Colao A, Pivonello R, Cavallo LM, Gaccione M, Auriemma RS, Esposito F, et al. Age changes the diagnostic accuracy of mean profile and nadir growth hormone levels after oral glucose in postoperative patients with acromegaly. Clin Endocrinol (Oxf) 2006;65:250-6.
    • (2006) Clin Endocrinol (Oxf) , vol.65 , pp. 250-256
    • Colao, A.1    Pivonello, R.2    Cavallo, L.M.3    Gaccione, M.4    Auriemma, R.S.5    Esposito, F.6
  • 37
    • 0023627682 scopus 로고
    • Characterization of serum growth hormone (GH) and insulin-like growth factor I in active acromegaly with minimal elevation of serum GH
    • Daughaday WH, Starkey RH, Saltman S, Gavin JR, 3rd, Mills-Dunlap B, Heath-Monnig E. Characterization of serum growth hormone (GH) and insulin-like growth factor I in active acromegaly with minimal elevation of serum GH. J Clin Endocrinol Metab 1987;65:617-23.
    • (1987) J Clin Endocrinol Metab , vol.65 , pp. 617-623
    • Daughaday, W.H.1    Starkey, R.H.2    Saltman, S.3    Gavin 3rd, J.R.4    Mills-Dunlap, B.5    Heath-Monnig, E.6
  • 38
    • 2942694305 scopus 로고    scopus 로고
    • Determinants of survival in treated acromegaly in a single center: Predictive value of serial insulin-like growth factor I measurements
    • Biermasz NR, Dekker FW, Pereira AM, van Thiel SW, Schutte PJ, van Dulken H, et al. Determinants of survival in treated acromegaly in a single center: predictive value of serial insulin-like growth factor I measurements. J Clin Endocrinol Metab 2004;89:2789-96.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2789-2796
    • Biermasz, N.R.1    Dekker, F.W.2    Pereira, A.M.3    van Thiel, S.W.4    Schutte, P.J.5    van Dulken, H.6
  • 41
    • 0023684610 scopus 로고
    • Plasma insulin-like growth factor-I/somatomedin-C in acromegaly: Correlation with the degree of growth hormone hypersecretion
    • Barkan AL, Beitins IZ, Kelch RP. Plasma insulin-like growth factor-I/somatomedin-C in acromegaly: correlation with the degree of growth hormone hypersecretion. J Clin Endocrinol Metab 1988;67:69-73.
    • (1988) J Clin Endocrinol Metab , vol.67 , pp. 69-73
    • Barkan, A.L.1    Beitins, I.Z.2    Kelch, R.P.3
  • 42
    • 28744446861 scopus 로고    scopus 로고
    • Postoperative evaluation of patients with acromegaly: Clinical significance and timing of oral glucose tolerance testing and measurement of (free) insulin-like growth factor I, acid-labile subunit and growth hormone binding protein levels
    • Feelders RA, Bidlingmaier M, Strasburger CJ, Janssen JA, Uitterlinden P, Hofland LJ, et al. Postoperative evaluation of patients with acromegaly: clinical significance and timing of oral glucose tolerance testing and measurement of (free) insulin-like growth factor I, acid-labile subunit and growth hormone binding protein levels. J Clin Endocrinol Metab 2005;90(12):6480-9.
    • (2005) J Clin Endocrinol Metab , vol.90 , Issue.12 , pp. 6480-6489
    • Feelders, R.A.1    Bidlingmaier, M.2    Strasburger, C.J.3    Janssen, J.A.4    Uitterlinden, P.5    Hofland, L.J.6
  • 44
    • 0027241101 scopus 로고
    • Relationships between insulin-like growth factor-1 levels and growth hormone concentrations during diurnal profiles and following oral glucose in acromegaly
    • Dobrashian RD, O'Halloran DJ, Hunt A, Beardwell CG, Shalet SM. Relationships between insulin-like growth factor-1 levels and growth hormone concentrations during diurnal profiles and following oral glucose in acromegaly. Clin Endocrinol (Oxf) 1993;38:589-93.
    • (1993) Clin Endocrinol (Oxf) , vol.38 , pp. 589-593
    • Dobrashian, R.D.1    O'Halloran, D.J.2    Hunt, A.3    Beardwell, C.G.4    Shalet, S.M.5
  • 46
    • 1442352333 scopus 로고    scopus 로고
    • Significance of "abnormal" nadir growth hormone levels after oral glucose in postoperative patients with acromegaly in remission with normal insulin-like growth factor-I levels
    • Freda PU, Nuruzzaman AT, Reyes CM, Sundeen RE, Post KD. Significance of "abnormal" nadir growth hormone levels after oral glucose in postoperative patients with acromegaly in remission with normal insulin-like growth factor-I levels. J Clin Endocrinol Metab 2004;89:495-500.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 495-500
    • Freda, P.U.1    Nuruzzaman, A.T.2    Reyes, C.M.3    Sundeen, R.E.4    Post, K.D.5
  • 47
    • 17044384113 scopus 로고    scopus 로고
    • Clinical indicators of biochemical remission in acromegaly: Does incomplete disease control always mean therapeutic failure?
    • Damjanovic SS, Neskovic AN, Petakov MS, Popovic V, Macut D, Vukojevic P, et al. Clinical indicators of biochemical remission in acromegaly: does incomplete disease control always mean therapeutic failure? Clin Endocrinol (Oxf) 2005;62:410-7.
    • (2005) Clin Endocrinol (Oxf) , vol.62 , pp. 410-417
    • Damjanovic, S.S.1    Neskovic, A.N.2    Petakov, M.S.3    Popovic, V.4    Macut, D.5    Vukojevic, P.6
  • 49
    • 10344238021 scopus 로고    scopus 로고
    • The regulation of GH secretion by sex steroids
    • Chowen JA, Frago LM, Argente J. The regulation of GH secretion by sex steroids. Eur J Endocrinol 2004;151(suppl. 3):U95-100.
    • (2004) Eur J Endocrinol , vol.151 , Issue.SUPPL. 3
    • Chowen, J.A.1    Frago, L.M.2    Argente, J.3
  • 50
    • 0035742584 scopus 로고    scopus 로고
    • Commercial assays available for insulin-like growth factor I and their use in diagnosing growth hormone deficiency
    • Clemmons DR. Commercial assays available for insulin-like growth factor I and their use in diagnosing growth hormone deficiency. Horm Res 2001;55(suppl. 2):73-9.
    • (2001) Horm Res , vol.55 , Issue.SUPPL. 2 , pp. 73-79
    • Clemmons, D.R.1


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