Differentiation between pancreaticobiliary and upper gastrointestinal adenocarcinomas: Is analysis of cytokeratin 17 expression helpful?

American Journal of Clinical Pathology

Volumn 128, Issue 2, 2007, Pages 255-259

  Sarbia, Mario ^a   Fritze, Frauke ^a   Geddert, Helene ^b   Von Weyhern, Claus ^c   Rosenberg, Robert ^d   Gellert, Klaus ^a  

^a SANA KLINIKUM OFFENBACH   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Adenocarcinoma of unknown primary; Cancer of extrahepatic bile ducts; Distal gastric cancer; Esophageal cancer; Gastric cardiac cancer; Pancreatic cancer

Indexed keywords

CYTOKERATIN 17;

ADULT; AGED; ARTICLE; BILE DUCT CARCINOMA; CARDIA CARCINOMA; COLORECTAL CARCINOMA; COLORECTAL TUMOR; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; ESOPHAGEAL ADENOCARCINOMA; FEMALE; GASTROINTESTINAL CARCINOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRAHEPATIC BILE DUCT; MALE; PANCREAS ADENOCARCINOMA; PREVALENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH ADENOCARCINOMA; TISSUE MICROARRAY;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; BILE DUCT NEOPLASMS; FEMALE; GASTROINTESTINAL NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; KERATIN-17; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; TISSUE ARRAY ANALYSIS;

EID: 34547892659     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/EEML5CH79PWD0R2D     Document Type: Article

References (9)

1. Dennis JL, Hvidsten TR, Wit EC, et al. Markers of adenocarcinoma characteristic of the site of origin: development of a diagnostic algorithm. Clin Cancer Res. 2005;11:3766-3772.
2. Kende AI, Carr NJ, Sobin LH. Expression of cytokeratins 7 and 20 in carcinomas of the gastrointestinal tract. Histopathology. 2003;42:137-140.
3. Werling RW, Yaziji H, Bacchi CE, et al. CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: an immunohistochemical survey of 476 primary and metastatic carcinomas. Am J Surg Pathol. 2003;27:303-310.
4. Chu PG, Schwarz RE, Lau SK, et al. Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2. Am J Surg Pathol. 2005;29:359-367.
5. Miettinen M, Nobel MP, Tuma BT, et al. Keratin 17: immunohistochemical mapping of its distribution in human epithelial tumors and its potential application. Appl Immunohistochem. 1997;5:152-159.
6. Goldstein NS, Bassi D. Cytokeratins 7, 17, and 20 reactivity in pancreatic and ampulla of Vater adenocarcinomas: percentage of positivity and distribution is affected by the cut-point threshold. Am J Clin Pathol. 2001;115:695-702.
7. Kim MA, Lee HS, Yang HK, et al. Cytokeratin expression profile in gastric carcinomas. Hum Pathol. 2004;35:576-581.
8. Sobin LH, Wittekind C, for the International Union Against Cancer (UICC), eds. TNM Classification of Malignant Tumours. 6th ed. New York, NY: Wiley-Liss; 2002.
9. Sarbia M. The histological appearance of oesophageal adenocarcinoma: an analysis based on 215 resection specimens. Virchows Arch. 2006;448:532-538.