Acceleration of autoimmunity by organochlorine pesticides: A comparison of splenic B-Cell effects of chlordecone and estradiol in (NZBxNZW)F1 Mice

Toxicological Sciences

Volumn 99, Issue 1, 2007, Pages 141-152

  Wang, Fei ^a,c   Roberts, Stephen M ^a,b   Butfiloski, Edward J ^b   Morel, Laurence ^b   Sobel, Eric S ^b  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Autoimmunity; Chlordecone; Estrogen; Spleen; Splenocytes; Systemic lupus erythematosus

Indexed keywords

AUTOANTIBODY; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR5; CHLORDECONE; ESTRADIOL; GLYCOL SALICYLATE; INTERCELLULAR ADHESION MOLECULE 1; ORGANOCHLORINE PESTICIDE; PROTEIN BCL 2; PROTEIN TYROSINE PHOSPHATASE SHP 1; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; APOPTOSIS; ARTICLE; AUTOIMMUNITY; CELL ACTIVATION; CELL COMPOSITION; COMPARATIVE STUDY; CONTROLLED STUDY; ESTROGEN ACTIVITY; FEMALE; GENE EXPRESSION; GERMINAL CENTER; IMMUNE SYSTEM; MOUSE; MOUSE STRAIN; NONHUMAN; OVARIECTOMY; PROTEIN EXPRESSION; SPLEEN CELL; SYSTEMIC LUPUS ERYTHEMATOSUS; UPREGULATION;

ANIMALS; ANTIGENS, DIFFERENTIATION; APOPTOSIS; AUTOIMMUNITY; B-LYMPHOCYTES; CELL PROLIFERATION; CHLORDECONE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ESTRADIOL; FEMALE; GERMINAL CENTER; INSECTICIDES; INTERCELLULAR ADHESION MOLECULE-1; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED STRAINS; OVARIECTOMY; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, CHEMOKINE; RECEPTORS, CXCR4; SHP1 PROTEIN TYROSINE PHOSPHATASE; SPLEEN; UP-REGULATION; VASCULAR CELL ADHESION MOLECULE-1;

MUS;

EID: 34547880380     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm137     Document Type: Article

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