CMV-induced neonatal thrombocytopenia: A case report and review of the literature

American Journal of Perinatology

Volumn 24, Issue 7, 2007, Pages 429-434

  Aslam, Muhammad ^a   Anderson, Jennifer L ^a   Guglietti, Deborah ^a   Cardwell, Dorcas ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

CMV immunoglobulin; Cytomegalovirus; Ganciclovir; Hearing loss; Intracranial calcifications; Thrombocytopenia; TORCH

Indexed keywords

AMPICILLIN; CYTOMEGALOVIRUS ANTIBODY; GANCICLOVIR; GENTAMICIN; VALGANCICLOVIR;

CASE REPORT; CYTOMEGALOVIRUS INFECTION; FEMALE; FOLLOW UP; HEARING TEST; HUMAN; INFECTION COMPLICATION; NEWBORN; NEWBORN INFECTION; PETECHIA; PRIORITY JOURNAL; REVIEW; SCREENING TEST; SPLENOMEGALY; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; URINE CULTURE; VIRUS CULTURE; VIRUS DIAGNOSIS;

ANTIVIRAL AGENTS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; FEMALE; GANCICLOVIR; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; INFANT, NEWBORN; PLATELET TRANSFUSION; THROMBOCYTOPENIA;

EID: 34547872378     PISSN: 07351631     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-984409     Document Type: Review

References (33)

1. Demmler GJ. Cytomegalovirus. In: Feigin RD, Cherry JD, Demmler GJ, Kaplan SL, eds. Textbook of Pediatric Infectious Diseases. 5th ed. Philadelphia: Saunders; 2004: 1912
2. Mocarski ES. Cytomegaloviruses and their replication. In: Fields B, Knipe D, Howley P eds. Virology. Vol. 2. 3rd ed. Philadelphia: Lippincott-Raven; 1996:2447
3. Walker A, Petheram SJ, Ballard L, et al. Characterization of human cytomegalovirus strains by analysis of short tandem repeat polymorphisms. J Clin Microbiol 2001;39:2219-2226
4. Demmler GJ. Infectious Diseases Society of America and Centers for Disease Control. Summary of a workshop on surveillance for congenital cytomegalovirus disease. Rev Infect Dis 1991;13:315-329
5. Hamprecht K, Maschmann J, Vochem M, et al. Epidemiology of transmission of cytomegalovirus from mother to preterm infant by breastfeeding. Lancet 2001;357:513-518
6. Maschmann J, Hamprecht K, Dietz K, et al. Cytomegalovirus infection of extremely low-birth weight infants via breast milk. Clin Infect Dis 2001;33:1998-2003
7. Neuberger P, Hamprecht K, Vochem M, et al. Case-control study of symptoms and neonatal outcome of human milk-transmitted cytomegalovirus infection in premature infants. J Pediatr 2006;148:326-331
8. Malm G, Engman ML. Congenital cytomegalovirus infections. Semin Fetal Neonatal Med 2007;12:154-159
9. Fowler KB, Stagno S, Pass RF. Maternal age and congenital cytomegalovirus infection: screening of two diverse newborn populations, 1980-1990. J Infect Dis 1993;168:552-556
10. Kylat RI, Kelly EN, Ford-Jones EL. Clinical findings and adverse outcome in neonates with symptomatic congenital cytomegalovirus (SCCMV) infection. Eur J Pediatr 2006;165:773-778
11. Noyola DE, Demmler GJ, Nelson CT, et al. Early predictors of neurodevelopmental outcome in symptomatic congenital cytomegalovirus infection. J Pediatr 2001;138:325-331
12. Boppana SB, Fowler KB, Vaid Y, et al. Neuroradiographic findings in the newborn period and long-term outcome in children with symptomatic congenital cytomegalovirus infection. Pediatrics 1997;99:409-414
13. Coats DK, Demmler GJ, Paysse EA, et al. Ophthalmologic findings in children with congenital cytomegalovirus infection. J AAPOS 2000;4:110-116
14. Istas AS, Demmler GJ, Dobbins JG, et al. Surveillance for congenital cytomegalovirus disease: a report from the National Congenital Cytomegalovirus Disease Registry. Clin Infect Dis 1995;20:665-670
15. Hicks T, Fowler K, Richardson M, et al. Congenital cytomegalovirus infection and neonatal auditory screening. J Pediatr 1993;123:779-782
16. Williamson WD, Demmler GJ, Percy AK, Catlin FI. Progressive hearing loss in infants with asymptomatic congenital cytomegalovirus infection. Pediatrics 1992;90:862-866
17. Fowler KB, McCollister FP, Dahle AJ, et al. Progressive and fluctuating sensorineural hearing loss in children with asymptomatic congenital cytomegalovirus infection. J Pediatr 1997;130:624-630
18. Boppana SB, Fowler KB, Pass RF, et al. Congenital cytomegalovirus infection: association between virus burden in infancy and hearing loss. J Pediatr 2005;146:817-823
19. Ross SA, Fowler KB, Ashrith G, et al. Hearing loss in children with congenital cytomegalovirus infection born to mothers with preexisting immunity. J Pediatr 2006;148:332-336
20. Jones RN, Neale ML, Beattie B, et al. Development and application of a PCR-based method including an internal control for diagnosis of congenital cytomegalovirus infection. J Clin Microbiol 2000;38:1-6
21. Grazia Revello M, Zavattoni M, Sarasini A, et al. Prenatal diagnostic and prognostic value of human cytomegalovirus load and IgM antibody response in blood of congenitally infected fetuses. J Infect Dis 1999;180:1320-1323
22. Nelson CT, Istas AS, Wilkerson MK, Demmler GJ. PCR detection of cytomegalovirus DNA in serum as a diagnostic test for congenital cytomegalovirus infection. J Clin Microbiol 1995;33:3317-3318
23. Demmler GJ, Buffone GJ, Schimbor CM, May RA. Detection of cytomegalovirus in urine from newborns by using polymerase chain reaction DNA amplification. J Infect Dis 1988;158:1177-1184
24. Whitley RJ, Cloud G, Gruber W, et al. Ganciclovir treatment of symptomatic congenital cytomegalovirus infection: results of a phase II study. J Infect Dis 1997;175:1080-1086
25. Kimberlin DW, Lin CY, Sanchez PJ, et al. Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial. J Pediatr 2003;143:16-25
26. Crumpacker CS. Ganciclovir. N Engl J Med 1996;335:721-729
27. Vallejo JG, Englund JA, Garcia-Prats JA, Demmler GJ. Ganciclovir treatment of steroid-associated cytomegalovirus disease in a congenitally infected neonate. Pediatr Infect Dis J 1994;13:239-241
28. Nigro G, Scholz H, Bartmann U. Ganciclovir therapy for symptomatic congenital cytomegalovirus infection in infants: a two-regimen experience. J Pediatr 1994;124:318-322
29. Xu HR, Li XN, Chen WL, Liu GY. Chu NN, Yu C. A sensitive assay for simultaneous determination of plasma concentrations of valganciclovir and its active metabolite ganciclovir by LC/MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci 2007;848:329-334
30. Adler SP, Nigro G, Pereira L. Recent advances in the prevention and treatment of congenital cytomegalovirus infections. Semin Perinatol 2007;31:10-18
31. Plotkin SA. Vaccination against cytomegalovirus, the changeling demon. Pediatr Infect Dis J 1999;18:313-325
32. Pass RF, Duliege AM, Boppana S, et al. A subunit cytomegalovirus vaccine based on recombinant envelope glycoprotein B and a new adjuvant. J Infect Dis 1999;180:970-975
33. American College of Obstetricians and Gynecologists (ACOG). Perinatal viral and parasitic infections. Washington, DC: American College of Obstetricians and Gynecologists; 200013. ACOG practice bulletin, no. 20