A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 18, 2007, Pages 5036-5040

  Renslo, Adam R ^a   Atuegbu, Andy ^a   Herradura, Prudencio ^a   Jaishankar, Priyadarshini ^a   Ji, Mingzhe ^a   Leach, Karen L ^a   Huband, Michael D ^a   Dermyer, Michael R ^a   Wu, Luping ^a   Vara Prasad, J V N ^a   Gordeev, Mikhail F ^a  

^a PFIZER INC   (United States)

Author keywords

Antibacterials; Azetidines; Mitochondrial protein synthesis inhibition; Oxazolidinones; Piperidines; Selectivity

Indexed keywords

ANTIINFECTIVE AGENT; LINEZOLID; OXAZOLIDINONE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CHEMICAL REACTION; DRUG SYNTHESIS; ESCHERICHIA COLI; HYDROGENATION; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MITOCHONDRION; PROTEIN SYNTHESIS INHIBITION;

ANTI-BACTERIAL AGENTS; ENTEROCOCCUS FAECALIS; MICROBIAL SENSITIVITY TESTS; MITOCHONDRIA; OXAZOLIDINONES; PROTEIN BIOSYNTHESIS; PROTEIN SYNTHESIS INHIBITORS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

EID: 34547867743     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.07.022     Document Type: Article

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