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Volumn 9, Issue 4, 2007, Pages 280-285

Advances in the immunopathophysiology of the idiopathic inflammatory myopathies: Not as simple as suspected

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CHEMOKINE; ANGIOGENIC FACTOR; INTERFERON;

EID: 34547865042     PISSN: 15233774     EISSN: 15346307     Source Type: Journal    
DOI: 10.1007/s11926-007-0045-7     Document Type: Review
Times cited : (5)

References (49)
  • 1
    • 0016850495 scopus 로고
    • Polymyositis and dermatomyositis (first of two parts)
    • Bohan A, Peter JB: Polymyositis and dermatomyositis (first of two parts). N Eng J Med 1975, 292:344-347.
    • (1975) N Eng J Med , vol.292 , pp. 344-347
    • Bohan, A.1    Peter, J.B.2
  • 2
    • 0016638734 scopus 로고
    • Polymyositis and dermatomyositis (second of two parts)
    • Bohan A, Peter JB: Polymyositis and dermatomyositis (second of two parts). N Eng J Med 1975, 292:403-407.
    • (1975) N Eng J Med , vol.292 , pp. 403-407
    • Bohan, A.1    Peter, J.B.2
  • 3
    • 0026429550 scopus 로고
    • Polymyositis, dermatomyositis, and inclusion-body myositis
    • Dalakas MC: Polymyositis, dermatomyositis, and inclusion-body myositis. N Eng J Med 1991, 325:1487-1498.
    • (1991) N Eng J Med , vol.325 , pp. 1487-1498
    • Dalakas, M.C.1
  • 4
    • 0141651951 scopus 로고    scopus 로고
    • Polymyositis and dermatomyositis
    • Dalakas MC, Hohlfeld R: Polymyositis and dermatomyositis. Lancet 2003, 362:971-982.
    • (2003) Lancet , vol.362 , pp. 971-982
    • Dalakas, M.C.1    Hohlfeld, R.2
  • 5
    • 0022619727 scopus 로고
    • Microvascular deposition of complement membrane attack complex in dermatomyositis
    • Kissel JT, Mendell JR, Rammohan KW: Microvascular deposition of complement membrane attack complex in dermatomyositis. N Eng J Med 1986, 314:329-334.
    • (1986) N Eng J Med , vol.314 , pp. 329-334
    • Kissel, J.T.1    Mendell, J.R.2    Rammohan, K.W.3
  • 6
    • 2642583192 scopus 로고    scopus 로고
    • Uncertainties in the pathogenesis of adult dermatomyositis
    • Greenberg SA, Amato AA: Uncertainties in the pathogenesis of adult dermatomyositis. Curr Opin Neurol 2004, 17:359-364.
    • (2004) Curr Opin Neurol , vol.17 , pp. 359-364
    • Greenberg, S.A.1    Amato, A.A.2
  • 8
    • 20944450759 scopus 로고    scopus 로고
    • Greenberg SA, Pinkus JL, Pinkus GS, et al.: Interferon-alpha/beta- mediated innate immune mechanisms in dermatomyositis. Ann Neurol 2005, 57:664-678. This study showed that the CD4+ cells in DM are not T-helper but plasmacytoid DCs. Furthermore, additional evidence is provided that perifascicular atrophy in DM is not caused by hypoperfusion.
    • Greenberg SA, Pinkus JL, Pinkus GS, et al.: Interferon-alpha/beta- mediated innate immune mechanisms in dermatomyositis. Ann Neurol 2005, 57:664-678. This study showed that the CD4+ cells in DM are not T-helper but plasmacytoid DCs. Furthermore, additional evidence is provided that perifascicular atrophy in DM is not caused by hypoperfusion.
  • 9
    • 20244390429 scopus 로고
    • The functional role of the ELR-motif in CXC chemokine-mediated angiogenesis
    • Strieter RM, Polverini PJ, Kunkel SL, et al.: The functional role of the ELR-motif in CXC chemokine-mediated angiogenesis. J Biol Chem 1995, 270:27348-27357.
    • (1995) J Biol Chem , vol.270 , pp. 27348-27357
    • Strieter, R.M.1    Polverini, P.J.2    Kunkel, S.L.3
  • 10
    • 26844496787 scopus 로고    scopus 로고
    • Association between lack of angiogenic response in muscle tissue and high expression of angiostatic ELR-negative CXC chemokines in patients with juvenile dermatomyositis
    • In a study of juvenile DM, it is shown that the angiopathy in this disease may be caused by an imbalance between chemokines
    • Fall N, Bove KE, Stringer K, et al.: Association between lack of angiogenic response in muscle tissue and high expression of angiostatic ELR-negative CXC chemokines in patients with juvenile dermatomyositis. Arthritis Rheum 2005, 52:3175-3180. In a study of juvenile DM, it is shown that the angiopathy in this disease may be caused by an imbalance between chemokines.
    • (2005) Arthritis Rheum , vol.52 , pp. 3175-3180
    • Fall, N.1    Bove, K.E.2    Stringer, K.3
  • 11
    • 22544458771 scopus 로고    scopus 로고
    • Human dendritic cells: Potent antigen-presenting cells at the crossroads of innate and adaptive immunity
    • Rossi M, Young JW: Human dendritic cells: potent antigen-presenting cells at the crossroads of innate and adaptive immunity. J Immunol 2005, 175:1373-1381.
    • (2005) J Immunol , vol.175 , pp. 1373-1381
    • Rossi, M.1    Young, J.W.2
  • 12
    • 0347719268 scopus 로고    scopus 로고
    • Anatomic localization of immature and mature dendritic cell subsets in dermatomyositis and polymyositis
    • This eloquent study showed that DCs are actively attracted to inflamed muscle tissue in DM and PM and that they mature locally
    • Page G, Chevrel G, Miossec P: Anatomic localization of immature and mature dendritic cell subsets in dermatomyositis and polymyositis. Arthritis Rheum 2004, 50:199-208. This eloquent study showed that DCs are actively attracted to inflamed muscle tissue in DM and PM and that they mature locally.
    • (2004) Arthritis Rheum , vol.50 , pp. 199-208
    • Page, G.1    Chevrel, G.2    Miossec, P.3
  • 13
    • 0031849974 scopus 로고    scopus 로고
    • Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites
    • Dieu MC, Vanbervliet B, Vicari A, et al.: Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J Exp Med 1998, 188:373-386.
    • (1998) J Exp Med , vol.188 , pp. 373-386
    • Dieu, M.C.1    Vanbervliet, B.2    Vicari, A.3
  • 14
    • 0037093852 scopus 로고    scopus 로고
    • Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ: Correlation with selective chemokine expression in rheumatoid synovium
    • Page G, Lebecque S, Miossec P: Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ: correlation with selective chemokine expression in rheumatoid synovium. J Immunol 2002, 168:5333-5341.
    • (2002) J Immunol , vol.168 , pp. 5333-5341
    • Page, G.1    Lebecque, S.2    Miossec, P.3
  • 15
    • 0032490628 scopus 로고    scopus 로고
    • Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naïve T cells and activated B cells
    • Ngo VN, Tang HL, Cyster JG: Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naïve T cells and activated B cells. J Exp Med 1998, 188:181-191.
    • (1998) J Exp Med , vol.188 , pp. 181-191
    • Ngo, V.N.1    Tang, H.L.2    Cyster, J.G.3
  • 16
    • 0021176654 scopus 로고
    • Monoclonal antibody analysis of mononuclear cells in myopathies. I: Quantitation of subsets according to diagnosis and sites of accumulation and demonstration and counts of muscle fibers invaded by T cells
    • Arahata K, Engel AG: Monoclonal antibody analysis of mononuclear cells in myopathies. I: Quantitation of subsets according to diagnosis and sites of accumulation and demonstration and counts of muscle fibers invaded by T cells. Ann Neurol 1984, 16:193-208.
    • (1984) Ann Neurol , vol.16 , pp. 193-208
    • Arahata, K.1    Engel, A.G.2
  • 17
    • 0033546053 scopus 로고    scopus 로고
    • The nature of the principal type 1 interferon-producing cells in human blood
    • Siegal FP, Kadowaki N, Shodell M, et al.: The nature of the principal type 1 interferon-producing cells in human blood. Science 1999, 284:1835-1837.
    • (1999) Science , vol.284 , pp. 1835-1837
    • Siegal, F.P.1    Kadowaki, N.2    Shodell, M.3
  • 18
    • 33845970203 scopus 로고    scopus 로고
    • Greenberg SA, Pinkus GS, Amato AA, Pinkus JL: Myeloid dendritic cells in inclusion-body myositis and polymyositis. Muscle Nerve 2007, 35:17-23. This is the third paper illustrating the important role of DCs in IIM, this time in PM and s-IBM.
    • Greenberg SA, Pinkus GS, Amato AA, Pinkus JL: Myeloid dendritic cells in inclusion-body myositis and polymyositis. Muscle Nerve 2007, 35:17-23. This is the third paper illustrating the important role of DCs in IIM, this time in PM and s-IBM.
  • 19
    • 0032476716 scopus 로고    scopus 로고
    • T cell receptor beta-chain repertoire in inclusion body myositis
    • Fyhr IM, Moslemi AR, Lindberg C, Oldfors A: T cell receptor beta-chain repertoire in inclusion body myositis. J Neuroimmunol 1998, 91:129-134.
    • (1998) J Neuroimmunol , vol.91 , pp. 129-134
    • Fyhr, I.M.1    Moslemi, A.R.2    Lindberg, C.3    Oldfors, A.4
  • 20
    • 0027272073 scopus 로고
    • Analysis of T cell receptor repertoire of muscle-infiltrating T lymphocytes in polymyositis: Restricted V alpha/beta rearrangements may indicate antigen-driven selection
    • Mantegazza R, Andreetta F, Bernasconi P, et al.: Analysis of T cell receptor repertoire of muscle-infiltrating T lymphocytes in polymyositis: restricted V alpha/beta rearrangements may indicate antigen-driven selection. J Clin Invest 1993, 91:2880-2886.
    • (1993) J Clin Invest , vol.91 , pp. 2880-2886
    • Mantegazza, R.1    Andreetta, F.2    Bernasconi, P.3
  • 21
    • 0028066166 scopus 로고
    • Predominant TCR-alpha beta variable and joining gene expression by muscle-infiltrating lymphocytes in the idiopathic inflammatory myopathies
    • O'Hanlon TP, Dalakas MC, Plotz PH, Miller FW: Predominant TCR-alpha beta variable and joining gene expression by muscle-infiltrating lymphocytes in the idiopathic inflammatory myopathies. J Immunol 1994, 152:2569-2576.
    • (1994) J Immunol , vol.152 , pp. 2569-2576
    • O'Hanlon, T.P.1    Dalakas, M.C.2    Plotz, P.H.3    Miller, F.W.4
  • 22
    • 0036890206 scopus 로고    scopus 로고
    • Evidence for heterogeneity of T cell expansion in polymyositis and inclusion body myositis
    • van der Meulen MF, van Wichen DF, van Blokland WT, et al.: Evidence for heterogeneity of T cell expansion in polymyositis and inclusion body myositis. J Neuroimmunol 2002, 133:198-204.
    • (2002) J Neuroimmunol , vol.133 , pp. 198-204
    • van der Meulen, M.F.1    van Wichen, D.F.2    van Blokland, W.T.3
  • 23
    • 33645085045 scopus 로고    scopus 로고
    • Shared blood and muscle CD8+ T-cell expansions in inclusion body myositis
    • Dimitri D, Benveniste O, Dubourg T, et al.: Shared blood and muscle CD8+ T-cell expansions in inclusion body myositis. Brain 2006, 129:986-995.
    • (2006) Brain , vol.129 , pp. 986-995
    • Dimitri, D.1    Benveniste, O.2    Dubourg, T.3
  • 24
    • 0028955369 scopus 로고
    • T cell receptor repertoire in polymyositis: Clonal expansion of autoaggressive CD8+ T cells
    • Bender A, Ernst N, Iglesias A, et al.: T cell receptor repertoire in polymyositis: clonal expansion of autoaggressive CD8+ T cells. J Exp Med 1995, 181:1863-1868.
    • (1995) J Exp Med , vol.181 , pp. 1863-1868
    • Bender, A.1    Ernst, N.2    Iglesias, A.3
  • 25
    • 0037388305 scopus 로고    scopus 로고
    • Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR, and CDR3-spectratype analysis
    • Hofbauer M, Wiesener S, Babbe H, et al.: Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR, and CDR3-spectratype analysis. Proc Natl Acad Sci U S A 2003, 100:4090-4095.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4090-4095
    • Hofbauer, M.1    Wiesener, S.2    Babbe, H.3
  • 26
    • 0033770618 scopus 로고    scopus 로고
    • Clonal restriction of T-cell receptor expression by infiltrating lymphocytes in inclusion body myositis persists over time: Studies in repeated muscle biopsies
    • Amemiya K, Granger RP, Dalakas MC: Clonal restriction of T-cell receptor expression by infiltrating lymphocytes in inclusion body myositis persists over time: studies in repeated muscle biopsies. Brain 2000, 123:2030-2039.
    • (2000) Brain , vol.123 , pp. 2030-2039
    • Amemiya, K.1    Granger, R.P.2    Dalakas, M.C.3
  • 27
    • 0041346169 scopus 로고    scopus 로고
    • Inclusion body myositis: Clonal expansions of muscle-infiltrating T cells persists over time
    • Muntzing K, Lindberg C, Moslemi AR, Oldfors A: Inclusion body myositis: clonal expansions of muscle-infiltrating T cells persists over time. Scan J Immunol 2003, 58:195-200.
    • (2003) Scan J Immunol , vol.58 , pp. 195-200
    • Muntzing, K.1    Lindberg, C.2    Moslemi, A.R.3    Oldfors, A.4
  • 28
    • 9644283197 scopus 로고    scopus 로고
    • Long-term persistence of clonally expanded T cells in patients with polymyositis
    • Benveniste O, Herson S, Salomon B, et al.: Long-term persistence of clonally expanded T cells in patients with polymyositis. Ann Neurol 2004, 56:867-872.
    • (2004) Ann Neurol , vol.56 , pp. 867-872
    • Benveniste, O.1    Herson, S.2    Salomon, B.3
  • 29
    • 0026354417 scopus 로고
    • A new approach to the classification of idiopathic inflammatory myopathy: Myositis-specific autoantibodies define useful homogeneous patient groups
    • Love LA, Leff RL, Fraser DD, et al.: A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific autoantibodies define useful homogeneous patient groups. Medicine (Baltimore) 1991, 70:360-374.
    • (1991) Medicine (Baltimore) , vol.70 , pp. 360-374
    • Love, L.A.1    Leff, R.L.2    Fraser, D.D.3
  • 30
    • 0037159180 scopus 로고    scopus 로고
    • Molecular profiles of inflammatory myopathies
    • Greenberg SA, Sanoudou D, Haslett JN, et al.: Molecular profiles of inflammatory myopathies. Neurology 2002, 59:1170-1182.
    • (2002) Neurology , vol.59 , pp. 1170-1182
    • Greenberg, S.A.1    Sanoudou, D.2    Haslett, J.N.3
  • 31
    • 33645086701 scopus 로고    scopus 로고
    • Plasma cells in muscle in inclusion body myositis and polymyositis
    • Greenberg SA, Bradshaw EM, Pinkus JL, et al.: Plasma cells in muscle in inclusion body myositis and polymyositis. Neurology 2005, 65:1782-1787.
    • (2005) Neurology , vol.65 , pp. 1782-1787
    • Greenberg, S.A.1    Bradshaw, E.M.2    Pinkus, J.L.3
  • 32
    • 33845952168 scopus 로고    scopus 로고
    • A local antigen-driven humoral response is present in the inflammatory myopathies
    • In an eloquent study, it is shown convincingly that an antigen-driven humoral response is present in all three forms of IIM, including PM and s-IBM, which are regarded as mainly characterized by the presence autoreactive T cells
    • Bradshaw EM, Orihuela A, McArdel SL, et al.: A local antigen-driven humoral response is present in the inflammatory myopathies. J Immunol 2007, 178:547-556. In an eloquent study, it is shown convincingly that an antigen-driven humoral response is present in all three forms of IIM, including PM and s-IBM, which are regarded as mainly characterized by the presence autoreactive T cells.
    • (2007) J Immunol , vol.178 , pp. 547-556
    • Bradshaw, E.M.1    Orihuela, A.2    McArdel, S.L.3
  • 33
    • 0027369730 scopus 로고
    • Myositis-specific autoantibodies. Touchstones for understanding the inflammatory myopathies
    • Miller FW: Myositis-specific autoantibodies. Touchstones for understanding the inflammatory myopathies. JAMA 1993, 270:1846-1849.
    • (1993) JAMA , vol.270 , pp. 1846-1849
    • Miller, F.W.1
  • 34
    • 14244267901 scopus 로고    scopus 로고
    • Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy
    • This study showed that regenerating muscle tissue in myositis patients expresses myositis-specific antigens, as do certain forms of cancer
    • Casciola-Rosen L, Nagaraju K, Plotz P, et al.: Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy. J Exp Med 2005, 201:591-601. This study showed that regenerating muscle tissue in myositis patients expresses myositis-specific antigens, as do certain forms of cancer.
    • (2005) J Exp Med , vol.201 , pp. 591-601
    • Casciola-Rosen, L.1    Nagaraju, K.2    Plotz, P.3
  • 35
    • 0016782856 scopus 로고
    • Polymyositis: Its presentation, morbidity and mortality
    • DeVere R, Bradley WG: Polymyositis: its presentation, morbidity and mortality. Brain 1975, 98:637-666.
    • (1975) Brain , vol.98 , pp. 637-666
    • DeVere, R.1    Bradley, W.G.2
  • 36
    • 0024604938 scopus 로고
    • Major histocompatibility complex class I antigen expression, immunolocalization of interferon subtypes, and T cell-mediated cytotoxicity in myopathies
    • Emslie-Smith AM, Arahata K, Engel AG: Major histocompatibility complex class I antigen expression, immunolocalization of interferon subtypes, and T cell-mediated cytotoxicity in myopathies. Hum Pathol 1989, 20:224-231.
    • (1989) Hum Pathol , vol.20 , pp. 224-231
    • Emslie-Smith, A.M.1    Arahata, K.2    Engel, A.G.3
  • 37
    • 0036010502 scopus 로고    scopus 로고
    • Interleukin-1alpha expression in capillaries and major histocompatibility complex class I expression in type II muscle fibers from polymyositis and dermatomyositis patients: Important pathogenic features independent of inflammatory cell clusters in muscle tissue
    • Englund P, Nennesmo I, Klareskog L, Lundberg IE: Interleukin-1alpha expression in capillaries and major histocompatibility complex class I expression in type II muscle fibers from polymyositis and dermatomyositis patients: important pathogenic features independent of inflammatory cell clusters in muscle tissue. Arthritis Rheum 2002, 46:1044-1055.
    • (2002) Arthritis Rheum , vol.46 , pp. 1044-1055
    • Englund, P.1    Nennesmo, I.2    Klareskog, L.3    Lundberg, I.E.4
  • 38
    • 0024360908 scopus 로고
    • Current concepts in the idiopathic inflammatory myopathies: Polymyositis, dermatomyositis, and related disorders
    • Plotz PH, Dalakas M, Leff RL, et al.: Current concepts in the idiopathic inflammatory myopathies: polymyositis, dermatomyositis, and related disorders. Ann Intern Med 1989, 111:143-157.
    • (1989) Ann Intern Med , vol.111 , pp. 143-157
    • Plotz, P.H.1    Dalakas, M.2    Leff, R.L.3
  • 39
    • 0028434704 scopus 로고
    • Temporal alterations of immunohistochemical findings in polymyositis
    • Tajima Y, Moriwaka F, Tashiro K: Temporal alterations of immunohistochemical findings in polymyositis. Intern Med 1994, 33:263-270.
    • (1994) Intern Med , vol.33 , pp. 263-270
    • Tajima, Y.1    Moriwaka, F.2    Tashiro, K.3
  • 40
    • 0028362071 scopus 로고
    • MHC class I, MHC class II and intracellular adhesion molecule-I (ICAM-I) expression in inflammatory myopathies
    • Bartoccioni E, Gallucci S, Scuderi F, et al.: MHC class I, MHC class II and intracellular adhesion molecule-I (ICAM-I) expression in inflammatory myopathies. Clin Exp Immunol 1994, 95:166-172.
    • (1994) Clin Exp Immunol , vol.95 , pp. 166-172
    • Bartoccioni, E.1    Gallucci, S.2    Scuderi, F.3
  • 41
    • 0032814894 scopus 로고    scopus 로고
    • Costimulatory markers in muscle of patients with idiopathic inflammatory myopathies and in cultured muscle cells
    • Nagaraju K, Raben N, Villalba ML, et al.: Costimulatory markers in muscle of patients with idiopathic inflammatory myopathies and in cultured muscle cells. Clin Immunol 1999, 92:161-169.
    • (1999) Clin Immunol , vol.92 , pp. 161-169
    • Nagaraju, K.1    Raben, N.2    Villalba, M.L.3
  • 42
    • 0034041459 scopus 로고    scopus 로고
    • Increased expression of interleukin 1alpha and MHC class I in muscle tissue of patients with chronic, inactive polymyositis and dermatomyositis
    • Nyberg P, Wikman AL, Nennesmo I, Lundberg IE: Increased expression of interleukin 1alpha and MHC class I in muscle tissue of patients with chronic, inactive polymyositis and dermatomyositis. J Rheumatol 2000, 27:940-948.
    • (2000) J Rheumatol , vol.27 , pp. 940-948
    • Nyberg, P.1    Wikman, A.L.2    Nennesmo, I.3    Lundberg, I.E.4
  • 43
    • 0011261078 scopus 로고    scopus 로고
    • Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies
    • Nagaraju K, Raben N, Loeffler L, et al.: Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies. Proc Natl Acad Sci U S A 2000, 97:9209-9214.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 9209-9214
    • Nagaraju, K.1    Raben, N.2    Loeffler, L.3
  • 44
    • 0036227950 scopus 로고    scopus 로고
    • Regulation of class I MHC expression in skeletal muscle: Deleterious effect of aberrant expression on myogenesis
    • Pavlath GK: Regulation of class I MHC expression in skeletal muscle: deleterious effect of aberrant expression on myogenesis. J Neuroimmunol 2002, 125:42-50.
    • (2002) J Neuroimmunol , vol.125 , pp. 42-50
    • Pavlath, G.K.1
  • 45
    • 0033562966 scopus 로고    scopus 로고
    • Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls
    • Kaufman RJ: Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev 1999, 13:1211-1233.
    • (1999) Genes Dev , vol.13 , pp. 1211-1233
    • Kaufman, R.J.1
  • 46
    • 0034716887 scopus 로고    scopus 로고
    • Tripartite management of unfolded proteins in the endoplasmc reticulum
    • Mori K: Tripartite management of unfolded proteins in the endoplasmc reticulum. Cell 2000, 101:451-454.
    • (2000) Cell , vol.101 , pp. 451-454
    • Mori, K.1
  • 47
    • 20744448833 scopus 로고    scopus 로고
    • Activation of the endoplasmic reticulum stress response in autoimmune myositis
    • Findings in this study showed that the ER stress response is activated in myositis and that this may be a major nonimmune mechanism responsible for skeletal muscle damage and dysfunction
    • Nagaraju K, Casciola-Rosen L, Lundberg I, et al.: Activation of the endoplasmic reticulum stress response in autoimmune myositis. Arthritis Rheum 2005, 52:1824-1835. Findings in this study showed that the ER stress response is activated in myositis and that this may be a major nonimmune mechanism responsible for skeletal muscle damage and dysfunction.
    • (2005) Arthritis Rheum , vol.52 , pp. 1824-1835
    • Nagaraju, K.1    Casciola-Rosen, L.2    Lundberg, I.3
  • 48
    • 0034730251 scopus 로고    scopus 로고
    • NF-kappaB-induced loss of MyoD messenger RNA: Possible role in muscle damage and cachexia
    • Guttridge DC, Mayo MW, Madrid LV, et al.: NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle damage and cachexia. Science 2000, 289:2363-2366.
    • (2000) Science , vol.289 , pp. 2363-2366
    • Guttridge, D.C.1    Mayo, M.W.2    Madrid, L.V.3
  • 49
    • 33751305449 scopus 로고    scopus 로고
    • Signs of inflammation in both symptomatic and asymptomatic muscles from patients with polymyositis and dermatomyositis
    • Dorph C, Englund P, Nennesmo I, Lundberg IE: Signs of inflammation in both symptomatic and asymptomatic muscles from patients with polymyositis and dermatomyositis. Ann Rheum Dis 2006, 65:1565-1571.
    • (2006) Ann Rheum Dis , vol.65 , pp. 1565-1571
    • Dorph, C.1    Englund, P.2    Nennesmo, I.3    Lundberg, I.E.4


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