Immunophenotypic characterization of anal gland carcinoma: Loss of p63 and cytokeratin 5/6

Archives of Pathology and Laboratory Medicine

Volumn 131, Issue 8, 2007, Pages 1304-1311

  Lisovsky, Mikhail ^a,c   Patel, Keyur ^a   Cymes, Karina ^a   Chase, Donald ^b   Bhuiya, Tawfiqul ^a   Morgenstern, Nora ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b California Tumor Tissue Registry   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CALPONIN; CYTOKERATIN 5; CYTOKERATIN 6; MYOSIN HEAVY CHAIN; PROTEIN P16; PROTEIN P53; PROTEIN P63; TRANSCRIPTION FACTOR CDX2;

ANUS CARCINOMA; ARTICLE; CANCER RECURRENCE; CLINICAL FEATURE; DEMOGRAPHY; HEMORRHOIDECTOMY; HISTOGENESIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; META ANALYSIS; METASTASIS; RECTUM ABDOMINOPERINEAL RESECTION; TREATMENT OUTCOME;

ADENOCARCINOMA; ANAL CANAL; ANUS NEOPLASMS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HEMORRHOIDS; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOPHENOTYPING; KERATIN-5; KERATIN-6; MALE; MEMBRANE PROTEINS; MIDDLE AGED; TUMOR MARKERS, BIOLOGICAL;

EID: 34547863863     PISSN: 00039985     EISSN: 15432165     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Fenger C. Tumours of the anal canal. In: Hamilton SR, Aaltonen LA, eds. Pathology and Genetics of Tumours of the Digestive System. Lyon, France: IARC Press; 2000:145-156. World Health Organization Classification of Tumours.
2. Jass JR, Sobin LH. Histological Typing of Intestinal Tumors. 2nd ed. Tokyo, Japan: Springer-Verlag; 1989.
3. Fenger C, Morson BC. Anal duct carcinoma. Dis Colon Rectum. 1989;32:355-357.
4. Wellman KF. Adenocarcinoma of anal duct origin. Can J Surg. 1962;5:311-318.
5. Basik M, Rodriguez-Bigas MA, Penetrante R, Petrelli NJ. Prognosis and recurrence patterns of anal adenocarcinoma. Am J Surg. 1995;169:233-23 7.
6. Nielsen OV, Koch F. Carcinomas of the anorectal region of extramucosal origin with special reference to the anal ducts. Acta Chir Scand. 1973;139:299-305.
7. Hobbs CM, Lowry MA, Owen D, Sobin LH. Anal gland carcinoma. Cancer. 2001;92:2045-2049.
8. Ramalingam P, Hart WR, Goldblum JR. Cytokeratin subset immunostaining in rectal adenocarcinoma and normal anal glands. Arch Pathol Lab Med. 2001;125:1074-1077.
9. Fenger C. Anal canal. In: Sternberg SS, ed. Histology for Pathologists. 2nd ed. Philadelphia, Pa: Lippincott-Raven Publishers; 1997:551-569.
10. McColl I. The comparative anatomy and pathology of anal glands. Ann R Coll Surg Engl. 1967;40:36-67.
11. Tucker CC, Hellwig CA. Histopathology of anal crypts. Surg Gynecol Obstet. 1933;58:145-149.
12. Grinvalsky HT, Helwig EB. Carcinoma of the anorectal junction, I: histological considerations. Cancer. 1956;9:480-488.
13. Fenger C, Filipe MI. Pathology of the anal glands with special reference to their mucin histochemistry. Acta Pathol Microbiol Scand A. 1977;85:273-285.
14. Kratzer GI. Histopathology of the anal ducts, Surg Gynecol Obstet. 1947;84:333-338.
15. Li MK, Folpe AL. CDX-2, a new marker for adenocarcinoma of gastrointestinal origin. Adv Anat Pathol. 2004;11:101-105.
16. Longo WE, Vernava AM III, Wade TP, Coplin MA, Virgo KS, Johnson FE. Rare anal canal cancers in the U.S. veteran: patterns of disease and results of treatment. Am Surg. 1995;61:495-500.
17. Winburn GB. Anal carcinoma or "just hemorrhoids"? Am Surg. 2001;67:1048-1058.
18. Lee SH, Zucker M, Sato T. Primary adenocarcinoma of an anal gland with secondary perianal fistulas. Hum Pathol. 1981;12:1034-1037.
19. Zaren HA, Delone FX, Lerner HJ. Carcinoma of the anal gland: case report and review of the literature. J Surg Oncol. 1983;23:250-254.
20. Parks TG. Mucus-secreting adenocarcinoma of anal gland origin. Br J Surg. 1970;57:434-436.
21. Winkelman J, Grosfeld J, Bigelow B. Colloid carcinoma of anal gland origin: report of a case and review of the literature. Am J Clin Pathol. 1964;42:395-401.
22. Wong AY, Rahilly MA, Adams W, Lee CS. Mucinous anal gland carcinoma with perianal Pagetoid spread. Pathology. 1998;30:1-3.
23. Nagtegaal I, Gaspar C, Marijnen C, Van De Velde C, Fodde R, Van Krieken H. Morphological changes in tumour type after radiotherapy are accompanied by changes in gene expression profile but not in clinical behaviour. J Pathol. 2004;204:183-192.
24. Tarazi R, Nelson RL. Anal adenocarcinoma: a comprehensive review. Semin Surg Oncol. 1994;10:235-240.
25. Abel ME, Chiu YS, Russell TR, Volpe PA. Adenocarcinoma of the anal glands: results of a survey. Dis Colon Rectum. 1993;36:383-387.
26. Jensen SL, Shokouh-Amiri MH, Hagen K, Harling H, Nielsen OV. Adenocarcinoma of the anal ducts: a series of 21 cases. Dis Colon Rectum. 1988;31:268-272.
27. Honore LH. Anal gland adenocarcinoma presenting as painless scrotal swelling in a 73-year-old man: a case report. J Surg Oncol. 1980;15:201-207.
28. Behan WM, Burnett RA. Adenocarcinoma of the anal glands. J Clin Pathol. 1996;49:1009-1011.
29. Perkowski PE, Sorrells DL, Evans JT, Nopajaroonsri C, Johnson LW. Anal duct carcinoma: case report and review of the literature. Am Surg. 2000;66:1149-1152.
30. Chu PG, Weiss LM. Keratin expression in human tissues and neoplasms. Histopathology. 2002;40:403-439.
31. Di Como CJ, Urist MJ, Babayan I, et al. P63 expression profiles in human normal and tumor tissues. Clin Cancer Res. 2002;8:494-501.
32. Urist MJ, Di Como CJ, Lu ML, et al. Loss of p63 expression is associated with tumor progression in bladder cancer. Am J Pathol. 2002;161:1199-1206.
33. Williams GR, Talbot IC, Northover JM, Leigh IM. Keratin expression in the normal anal canal. Histopathology. 1995;26:39-44.
34. Zhang PJ, Shah M, Spiegel GW, Brooks JJ. Cytokeratin 7 immunoreactivity in rectal adenocarcinomas. Appl Immunohistochem Mol Morphol. 2003;11:306-310.
35. Ohnishi T, Watanabe S. The use of cytokeratins 7 and 20 in the diagnosis of primary and secondary extramammary Paget's disease. Br J Dermatol. 2000;142:243-247.
36. Yeong ML, Wood KP, Scott B, Yun K. Synchronous squamous and glandular neoplasia of the anal canal. J Clin Pathol. 1992;45:261-263.
37. Levy R, Czernobilsky B, Geiger B. Cytokeratin polypeptide expression in a cloacogenic carcinoma and in the normal anal canal epithelium. Virchows Arch A Pathol Anat Histopathol. 1991;418:447-455.
38. Seow-Choen F, Ho JM. Histoanatomy of anal glands. Dis Colon Rectum. 1994;37:1215-1218.