Influence of the β-lactam resistance phenotype on the cefuroxime versus cefditoren susceptibility of Streptococcus pneumoniae and Haemophilus influenzae recovered from children with acute otitis media

Journal of Antimicrobial Chemotherapy

Volumn 60, Issue 2, 2007, Pages 323-327

  Fenoll, Asunción ^a   Aguilar, Lorenzo ^b   Robledo, Olga ^a   Giménez, María José ^b   Tarragó, David ^a   Granizo, Juan José ^c   Gimeno, Mercedes ^d   Coronel, Pilar ^d  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b SCHOOL OF MEDICINE   (Spain)

^c Grana Datos SL   (Spain)

^d Tedec Meiji Farma SA   (Spain)

Author keywords

Amoxicillin resistance; Antimicrobial susceptibility; Middle ear isolates; Paediatric isolates

Indexed keywords

AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; CEFDITOREN; CEFUROXIME; PENICILLIN G;

ACUTE OTITIS MEDIA; AGAR GEL DIFFUSION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CHILD; CONTROLLED STUDY; ENZYME SYNTHESIS; HAEMOPHILUS INFLUENZAE; HUMAN; MIDDLE EAR; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHENOTYPE; PREDICTION; SEROTYPE; STREPTOCOCCUS PNEUMONIAE;

ACUTE DISEASE; ANTI-BACTERIAL AGENTS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CEFUROXIME; CEPHALOSPORINS; CHILD; HAEMOPHILUS INFLUENZAE; HUMANS; MICROBIAL SENSITIVITY TESTS; OTITIS MEDIA; PHENOTYPE; STREPTOCOCCUS PNEUMONIAE;

EID: 34547849666     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkm209     Document Type: Article

References (27)

1. Hoberman A, Marchant CD, Kaplan SL et al. Treatment of acute otitis media consensus recommendations. Clin Pediatr (Phila) 2002; 41: 373-90.
2. Corbeel L. What is new in otitis media? Eur J Pediatr 2007; 166 511-9.
3. Fernändez Roblas R, Granizo JJ, Soriano F. Farmacodinamia del tratamiento antibiótico de la otitis media. Med Clin (Barc) 2000; 115: 70-2.
4. Marco F, Bouza E, Garcia-de-Lomas J et al. Streptococcus pneumoniae in community-acquired respiratory tract infections in Spain: The impact of serotype and geographical, seasonal and clinical factors on its susceptibility to the most commonly prescribed antibiotics. J Antimicrob Chemother 2000; 46: 557-64.
5. Block SL, Doem GV, Pfaller MA. Oral β-lactams in the treatment of acute otitis media. Diagn Microbiol Infect Dis 2007; 57 Suppl 1: S19-30.
6. Pérez-Trallero E, Marimón JM, Gonzalez A et al. Genetic relatedness of recently collected Spanish respiratory tract Streptococcus pneumoniae isolates with reduced susceptibility to amoxicillin. Antimicrob Agents Chemother 2003; 47: 3637-9.
7. García-de-Lomas J, Lerma M, Giménez MJ et al. Influence of H. influenzae β-lactamase production and/or ftsl gene mutations on in vitro activity of and susceptibility rates to aminopenicillins and second-and third-generation cophalosporins. Int J Antimicrob Agents 2007, in press.
8. Jansen WT, Verel A, Beitsma M et al. Longitudinal European surveillance study of antibiotic resistance of Haemophilus influenzae. J Antimicrob Chemother 2006; 58: 873-7.
9. Garau J. Both penicillin and amoxycillin should be tested in antimicrobial surveillance for Streptococcus pneumoniae. Clin Microbiol Infect 2005; 11: 422-3.
10. Soriano F, Granizo JJ, Fenoll A et al. Antimicrobial resistance among clinical isolates of Streptococcus pneumoniae isolated in four southern European countries (ARISE project) from adult patients: results from the cefditoren surveillance program. J Chemother 2003; 15: 107-12.
11. Soriano F, Granizo JJ, Coronel P et al. Antimicrobial susceptibility of Haemophilus influenzae, Haemophilus parainfluenzae and Moraxella catarrhalis isolated from adult patients with respiratory tract infections in four southern European countries. The ARISE project. Int J Antimicrob Agents 2004; 23: 296-9.
12. Wellington K, Curran MP. Cefditoren pivoxil: A review of its use in the treatment of bacterial infections. Drugs 2004; 64: 2597-618.
13. Alou L, Gimenez MJ, Sevillano D et al. Are β-lactam breakpoints adequate to define non-susceptibility for all Haemophilus influenzae resistance phenotypes from a pharmacodynamic point of view? J Antimicrob Chemother 2007; 59: 652-7.
14. Sevillano D, Giménez MJ, Alou L et al. Effects of human albumin and serum on the in vitro bactericidal activity of cefditoren against penicillin-resistant Streptococcus pneumoniae. J Antimicrob Chemother 2007; doi:10.1093/jac/dkm115.
15. Alvarez-Sala JL, Kardos P, Martinez-Beltran J et al. Clinical and bacteriological efficacy in treatment of acute exacerbations of chronic bronchitis with cefditoren-pivoxil versus cefuroxime-axetil. Antimicrob Agents Chemother 2006; 50: 1762-7.
16. Granizo JJ, Giménez MJ, Barberán J et al. Efficacy of cefditoren, focusing on S. pneumoniae and H. influenzae per-pathogen bacteriological response, in the treatment of lower respiratory tract infections: A pooled analysis of seven clinical trials. Clin Ther 2006; 28: 2061-9.
17. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing: Fifteenth Informational Supplement M100-S15. CLSI, Wayne, PA, USA, 2005.
18. Fenoll A, Jado I, Vicioso D et al. Dot blot assay for the serotyping of pneumococci. J Clin Microbiol 1997; 35: 764-6.
19. Clinical Laboratory Standards Institute. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically-Seventh Edition: Approved Standard M7-A7. CLSI, Wayne, PA, USA, 2006.
20. Clark CL, Nagai K, Dewasse BE et al. Activity of cefditoren against respiratory pathogens. J Antimicrob Chemother 2002; 50 33-41.
21. Pérez-Trallero E, Marimón JM, Ercibengoa M et al. Antimicrobial susceptibility of amoxicillin non-susceptible versus susceptible isolates among penicillin non-susceptible Streptococcus pneumoniae. Clin Microbiol Infect 2007, in press.
22. Fenoll A, Gimenez MJ, Robledo O et al. Activity of cefditoren against clinical isolates of Streptococcus pneumoniae showing nonsusceptibility to penicillins, cephalosporins, macrolides, ketolides or quinolones. Int J Antimicrob Agents 2007; 29: 224-6.
23. Camacho MT, Casal J, Aguilar L et al. Very high resistance to amoxicillin in Streptococcus pneumoniae: An epidemiological fact or a technical issue? J Chemother 2006; 18: 303-6.
24. Garcia-de-Lomas J, Garcia-Rey C, Lopez L et al. Susceptibility patterns of bacteria causing community-acquired respiratory infections in Spain: The SAUCE project. J Antimicrob Chemother 2002; 50 Suppl S2: 21-6.
25. Perez-Trallero E, Garcia-de-la-Fuente C, Garcia-Rey C et al. Geographical and ecological analysis of resistance, coresistance, and coupled resistance to antimicrobials in respiratory pathogenic bacteria in Spain. Antimicrob Agents Chemother 2005; 49: 1965-72.
26. MacGowan AP, Wise R. Establishing MIC breakpoints and the interpretation of in vitro susceptibility tests. J Antimicrob Chemother 2001; 48 Suppl S1: 17-28.
27. Latorre C, Sanfeliu I. Haemophilus influenzae: Caracteristicas fenotípicas de las cepas aisladas en 12 hospitales catalanes en un año. Enterm Infecc Microbiol Clin 2003; 21: 126-30.