Effects of human albumin and serum on the in vitro bactericidal activity of cefditoren against penicillin-resistant Streptococcus pneumoniae

Journal of Antimicrobial Chemotherapy

Volumn 60, Issue 1, 2007, Pages 156-158

  Sevillano, D ^a   Gimenez M J ^a   Alou, L ^a   Aguilar, L ^a   Cafini, F ^a   Torrico, M ^a   Gonzalez N ^a   Echeverria O ^a   Coronel, P ^b   Prieto, J ^a  

^a SCHOOL OF MEDICINE   (Spain)

^b Tedec Meiji Farma SA   (Spain)

Author keywords

Killing curves; Penicillin susceptibility; Pneumococci; Protein binding

Indexed keywords

AMOXICILLIN; CEFDITOREN; CEFOTAXIME; HUMAN ALBUMIN; PENICILLIN G;

ACCURACY; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; BACTERIUM CULTURE; CULTURE MEDIUM; IN VITRO STUDY; INOCULATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; SERUM; STATISTICAL SIGNIFICANCE; STREPTOCOCCUS PNEUMONIAE;

ANTI-BACTERIAL AGENTS; CEPHALOSPORINS; CULTURE MEDIA; HUMANS; MICROBIAL SENSITIVITY TESTS; PENICILLIN RESISTANCE; PROTEIN BINDING; SERUM; SERUM ALBUMIN; STREPTOCOCCUS PNEUMONIAE;

EID: 34447576587     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkm115     Document Type: Article

References (10)

1. Moellering RC, Eliopoulos GM. Principles of anti-infective therapy. In: Mandell GL, Bennett JE, Dolin R eds. Mandell, Douglas, and Bennett Principles and Practice of Infectious Diseases. Philadelphia: Elsevier Churchill Livingstone, 2005; 242-53.
2. Cha R, Rybak W. Influence of protein binding under controlled conditions on the bactericidal activity of daptomycin in an in vitro pharmacodynamic model. J Antimicrob Chemother 2004; 54: 259-62.
3. Palmer SM, Kang SL, Cappelletty DM et al. Bactericidal killing activities of cefepime, ceftazidime, cefotaxime, and ceftriaxone against Staphylococcus aureus and β-lactamase-producing strains of Enterobacter aerogenes and Klebsiella pneumoniae in an in vitro infection model. Antimicrob Agents Chemother 1995; 39 1764-71.
4. Boswell FJ, Ashby JP, Andrews JM et al. Effect of protein binding on the in vitro activity and pharmacodynamics of faropenem. J Antimicrob Chemother 2002; 50: 525-32.
5. Blandino G, Milazzo I, Musumeci R et al. Comparative activity of cefodizime and ceftriaxone against respiratory pathogens in an in vitro pharmacodynamic model simulating concentration-time curves. J Chemother 2000; 12: 503-8.
6. Casal J, Aguilar L, Jado I et al. Effects of specific antibodies against Streptococcus pneumoniae on pharmacodynamic parameters of β-lactams in a mouse sepsis model. Antimicrob Agents Chemother 2002; 46: 1340-4.
7. Casal J, Gimenez MJ, Aguilar L et al. β-Lactam activity against resistant pneumococcall strains is enhanced by the immune system. J Antimicrob Chemother 2002; 50: Suppl S2: 83-6.
8. Wellington K, Curran MP. Cefditoren pivoxil: A review of its use in the treatment of bacterial infections. Drugs 2004; 64: 2597-618.
9. Wright JD, Boudinot FD, Ujhelyi MR. Measurement and analysis of unbound drug concentrations. Clin Pharmacokinet 1996; 30: 445-62.
10. Firsov AA, Smirnova MV, Lubenko IY et al. Testing the mutant selection window hypothesis with Staphylococcus aureus exposed to daptomycin and vancomycin in an in vitro dynamic model. J Antimicrob Chemother 2006; 58: 1185-92.