Cathodal stimulation in the recovery phase of a propagating planar wave in the rabbit heart reveals four stimulation mechanisms

Journal of Physiology

Volumn 583, Issue 1, 2007, Pages 237-250

  Sidorov, Veniamin Y ^a,b   Woods, Marcella C ^a   Baudenbacher, Franz ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL TISSUE; ARTICLE; ARTIFICIAL HEART PACEMAKER; CONTROLLED STUDY; CRYOABLATION; DEFIBRILLATOR; DIASTOLE; ELECTRODE; ELECTROSTIMULATION; FEMALE; HEART CYCLE; HEART EXCITATION; HEART MUSCLE CELL; HEART PACING; HEART REPOLARIZATION; HEART STIMULATION; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; REFRACTORY PERIOD; TISSUE REACTION; CALCIUM TRANSPORT; CATHODAL STIMULATION; HEART MUSCLE REFRACTORY PERIOD; PROPAGATING PLANAR WAVE; RECOVERY PHASE;

ANIMALS; ELECTRIC STIMULATION; ELECTRODES; ELECTROPHYSIOLOGY; FEMALE; HEART CONDUCTION SYSTEM; MALE; MEMBRANE POTENTIALS; RABBITS; REFRACTORY PERIOD, ELECTROPHYSIOLOGICAL;

CALCIUM CHANNEL;

EID: 34547845205     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2007.137232     Document Type: Article

References (46)

1. Allessie MA, Schalij MJ, Kirchhof CJ, Boersma L, Huybers M & Hollen J (1989). Experimental electrophysiology and arrhythmogenicity. Anisotropy and ventricular tachycardia. Eur Heart J 10 (Suppl. E), 2-8.
2. Banville I & Gray RA (2002). Effect of action potential duration and conduction velocity restitution and their spatial dispersion on alternans and the stability of arrhythmias. J Cardiovasc Electrophysiol 13, 1141-1149.
3. Brugada J, Boersma L, Kirchhof C, Brugada P, Havenith M, Wellens HJ & Allessie MA (1990). Double-wave reentry as a mechanism of acceleration of ventricular tachycardia. Circulation 81, 1633-1643.
4. Chen PS, Wolf PD, Dixon EG, Danieley ND, Frazier DW, Smith WM & Ideker RE (1988). Mechanism of ventricular vulnerability to single premature stimuli in open-chest dogs. Circ Res 62, 1191-1209.
5. Cheng Y, Li L, Nikolski V, Wallick DW & Efimov IR (2004). Shock-induced arrhythmogenesis is enhanced by 2,3-butanedione monoxime compared with cytochalasin D. Am J Physiol Heart Circ Physiol 286, H310-H318.
6. Cranefield PF, Hoffman BF & Siebens AA (1957). Anodal excitation of cardiac muscle. Am J Physiol 190, 383-390.
7. Dekker E (1970). Direct current make and break thresholds for pacemaker electrodes on the canine ventricle. Circ Res 27, 811-823.
8. Evans FG & Gray RA (2004). Shock-induced epicardial and endocardial virtual electrodes leading to ventricular fibrillation via reentry, graded responses, and transmural activation. J Cardiovasc Electrophysiol 15, 79-87.
9. Frazier DW, Wolf PD, Wharton JM, Tang AS, Smith WM & Ideker RE (1989). Stimulus-induced critical point. Mechanism for electrical initiation of reentry in normal canine myocardium. J Clin Invest 83, 1039-1052.
10. Goldman Y & Morad M (1977). Ionic membrane conductance during the time course of the cardiac action potential. J Physiol 268, 655-695.
11. Gotoh M, Uchida T, Mandel WJ, Fishbein MC, Chen PS & Karagueuzian HS (1997). Cellular graded responses and ventricular vulnerability to reentry by a premature stimulus in isolated canine ventricle. Circulation 95, 2141-2154.
12. Gray RA, Huelsing DJ, Aguel F & Trayanova NA (2001). Effect of strength and timing of transmembrane current pulses on isolated ventricular myocytes. J Cardiovasc Electrophysiol 12, 1129-1137.
13. Henriquez CS (1993). Simulating the electrical behavior of cardiac tissue using the bidomain model. Crit Rev Biomed Eng 21, 1-77.
14. Hoffman BF, Gorin EF, Wax FS, Siebens AA & Brooks CM (1951). Vulnerability to fibrillation and the ventricular-excitability curve. Am J Physiol 167, 88-94.
15. Hoffman BF, Kao CY & Suckling EE (1957). Refractoriness in cardiac muscle. Am J Physiol 190, 473-482.
16. Kao CY & Hoffman BF (1958). Graded and decremental response in heart muscle fibers. Am J Physiol 194, 187-196.
17. Kettlewell S, Walker NL, Cobbe SM, Burton FL & Smith GL (2004). The electrophysiological and mechanical effects of 2,3-butane-dione monoxime and cytochalasin-D in the Langendorff perfused rabbit heart. Exp Physiol 89, 163-172.
18. Knisley SB (1995). Transmembrane voltage changes during unipolar stimulation of rabbit ventricle. Circ Res 77, 1229-1239.
19. Knisley SB, Smith WM & Ideker RE (1992). Effect of field stimulation on cellular repolarization in rabbit myocardium. Implications for reentry induction. Circ Res 70, 707-715.
20. Lin SF, Roth BJ & Wikswo JP Jr (1999). Quatrefoil reentry in myocardium: An optical imaging study of the induction mechanism. J Cardiovasc Electrophysiol 10, 574-586.
21. Lindblom AE, Roth BJ & Trayanova NA (2000). Role of virtual electrodes in arrhythmogenesis: Pinwheel experiment revisited. J Cardiovasc Electrophysiol 11, 274-285.
22. Nachlas MM & Shnitka TK (1963). Macroscopic identification of early myocardial infarcts by alterations in dehydrogenase activity. Am J Pathol 42, 379-405.
23. Neunlist M & Tung L (1995). Spatial distribution of cardiac transmembrane potentials around an extracellular electrode: Dependence on fiber orientation. Biophys J 68, 2310-2322.
24. Plonsey R & Barr RC (1984). Current flow patterns in two-dimensional anisotropic bisyncytia with normal and extreme conductivities. Biophys J 45, 557-571.
25. Roth BJ (1992). How the anisotropy of the intracellular and extracellular conductivities influences stimulation of cardiac muscle. J Math Biol 30, 633-646.
26. Roth BJ (1995). A mathematical model of make and break electrical stimulation of cardiac tissue by a unipolar anode or cathode. IEEE Trans Biomed Eng 42, 1174-1184.
27. Roth BJ (1998). The pinwheel experiment revisited. J Theor Biol 190, 389-393.
28. Roth BJ & Wikswo JP Jr (1986). A bidomain model for the extracellular potential and magnetic field of cardiac tissue. IEEE Trans Biomed Eng 33, 467-469.
29. Sambelashvili A & Efimov IR (2002). The pinwheel experiment re-revisited. J Theor Biol 214, 147-153.
30. Sepulveda NG, Roth BJ & Wikswo JP Jr (1989). Current injection into a two-dimensional anisotropic bidomain. Biophys J 55, 987-999.
31. Sepulveda NG & Wikswo JP Jr (1987). Electric and magnetic fields from two-dimensional anisotropic bisyncytia. Biophys J 51, 557-568.
32. Sepulveda NG & Wikswo JP Jr (1994). Bipolar stimulation of cardiac tissue using an anisotropic bidomain model. J Cardiovasc Electrophysiol 5, 258-267.
33. Shibata N, Chen PS, Dixon EG, Wolf PD, Danieley ND, Smith WM & Ideker RE (1988 a). Epicardial activation after unsuccessful defibrillation shocks in dogs. Am J Physiol Heart Circ Physiol 255, H902-H909.
34. Shibata N, Chen PS, Dixon EG, Wolf PD, Danieley ND, Smith WM & Ideker RE (1988 b). Influence of shock strength and timing on induction of ventricular arrhythmias in dogs. Am J Physiol Heart Circ Physiol 255, H891-H901.
35. Sidorov VY, Aliev RR, Woods MC, Baudenbacher F, Baudenbacher P & Wikswo JP (2003 a). Spatiotemporal dynamics of damped propagation in excitable cardiac tissue. Phys Rev Lett 91, 208104.
36. Sidorov VY, Woods MC, Baudenbacher P & Baudenbacher F (2005). Examination of stimulation mechanism and strength-interval curve in cardiac tissue. Am J Physiol Heart Circ Physiol 289, H2602-H2615.
37. Sidorov VY, Woods MC & Wikswo JP (2003 b). Effects of elevated extracellular potassium on the stimulation mechanism of diastolic cardiac tissue. Biophys J 84, 3470-3479.
38. Skale BT, Kallok MJ, Prystowsky EN, Gill RM & Zipes DP (1985). Inhibition of premature ventricular extrastimuli by subthreshold conditioning stimuli. J Am Coll Cardiol 6, 133-140.
39. Trayanova NA, Gray RA, Bourn DW & Eason JC (2003). Virtual electrode-induced positive and negative graded responses: New insights into fibrillation induction and defibrillation. J Cardiovasc Electrophysiol 14, 756-763.
40. Trayanova NA & Henriquez CS (1991). Modification of a cylindrical bidomain model for cardiac tissue. Math Biosci 104, 59-72.
41. Wikswo JP Jr (1994). The complexities of cardiac cables: Virtual electrode effects. Biophys J 66, 551-553.
42. Wikswo JP Jr (1995). Tissue anisotropy, the cardiac bidomain and the virtual cathode effect. In Cardiac Electrophysiology: From Cell to Bedside, ed. Zipes D & Jalife J, pp. 348-361. Saunders, Philadelphia.
43. Wikswo JP Jr, Lin SF & Abbas RA (1995). Virtual electrodes in cardiac tissue: A common mechanism for anodal and cathodal stimulation. Biophys J 69, 2195-2210.
44. Winfree AT (1983). Sudden cardiac death: A problem in topology. Sci Am 248, 144-161.
45. Winfree AT (1987). When Time Breaks Down: The Three-Dimensional Dynamics of Electrochemical Waves and Cardiac Arrhythmias. Princeton University Press, Princeton.
46. Winfree AT (1989). Electrical instability in cardiac muscle: Phase singularities and rotors. J Theor Biol 138, 353-405.