Systematic review of the effectiveness of pharmacological treatments for adolescents and adults with autism spectrum disorder

Autism

Volumn 11, Issue 4, 2007, Pages 335-348

  Broadstock, Marita ^a   Doughty, Carolyn ^a   Eggleston, Matt ^b  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b Christchurch District Health Board   (New Zealand)

Author keywords

Adolescent; Adult; Autistic disorder; Drug therapies; Systematic review

Indexed keywords

CLOMIPRAMINE; FLUVOXAMINE; HALOPERIDOL; NALTREXONE; PLACEBO; RISPERIDONE;

ADOLESCENT; ADULT; AGE; AUTISM; AUTOMUTILATION; BIBLIOGRAPHIC DATABASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; EVIDENCE BASED MEDICINE; EXTRAPYRAMIDAL SYMPTOM; FATIGUE; HUMAN; LETHARGY; LOW DRUG DOSE; MEDICAL LITERATURE; MEDICAL RESEARCH; METHODOLOGY; NAUSEA; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RELIABILITY; REVIEW; SAMPLE SIZE; SEDATION; SIDE EFFECT; SINGLE DRUG DOSE; SYSTEMATIC REVIEW; TREATMENT DURATION; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT; WEIGHT GAIN;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AUTISTIC DISORDER; CHILD; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 34547844298     PISSN: 13623613     EISSN: 14617005     Source Type: Journal    
DOI: 10.1177/1362361307078132     Document Type: Review

References (34)

1. American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders: DSM III. Washington, DC: APA.
2. Barnard, L., Young, A.H., Pearson, J., Geddes, J. & O'Brien, G. (2002) 'A Systematic Review of the Use of Atypical Antipsychotics in Autism', Journal of Psychopharmacology 16: 93-101.
3. Broadstock, M. & Doughty, C. (2003) 'The Effectiveness of Pharmacological Therapies for Young People and Adults with Autism Spectrum Disorder (ASD)', NZHTA Report 6: 1-77.
4. Di Martino, A. & Tuchman, R.F. (2001) 'Antiepileptic Drugs: Affective Use in Autism Spectrum Disorders', Pediatric Neurology 25: 199-207.
5. Esch, B.E. & Carr, J.E. (2004) 'Secretin as a Treatment for Autism: A Review of the Evidence', Journal of Autism and Developmental Disorders 34 (5): 543-56.
6. Kerbeshian, J., Burd, L. & Avery, K. (2001) 'Pharmacotherapy of Autism: A Review and Clinical Approach', Journal of Developmental & Physical Disabilities 13: 199-228.
7. Kleijnen, J.. & Knipschild, P. (1991) 'Niacin and Vitamin B6 in Mental Functioning: A Review of Controlled Trials in Humans', Biological Psychiatry 29: 931-41.
8. Korkmaz, B. (2000) 'Infantile Autism: Adult Outcome', Seminars in Clinical Neuropsychiatry 5: 164-70.
9. Langworthy-Lam, K.S., Aman, M.G. & Van Bourgondien, M.E. (2002) 'Prevalence and Patterns of Use of Psychoactive Medicines in Individuals with Autism in the Autism Society of North Carolina', Journal of Child and Adolescent Psychopharmacology (124): 311-321.
10. Larkin, M.. (1997) 'Approaches to Amelioration of Autism in Adulthood', Lancet 349: 186.
11. Larsen, F.W. & Mouridsen, S.E. (1997) 'The Outcome in Children with Childhood Autism and Asperger Syndrome Originally Diagnosed as Psychotic: A 30-Year Follow-Up Study of Subjects Hospitalized as Children', European Child & Adolescent Psychiatry 6: 181-190.
12. Lord, C. (2000) 'Commentary: Achievements and Future Directions for Intervention Research in Communication and Autism Spectrum Disorders', Journal of Autism & Developmental Disorders 30: 393-8.
13. Mcdougle, C.J., Naylor, S.T., Cohen, D.J., Volkmar, F.R., Heninger, G.R. & Price, L.H. (1996) 'A Double-Blind, Placebo-Controlled Study of Fluvoxamine in Adults with Autistic Disorder', Archives of General Psychiatry 53: 1001-8.
14. Mcdougle, C.J., Holmes, J.P., Carlson, D.C., Pelton, G.H., Cohen, D.J. & Price, L.H. (1998) 'A Double-Blind, Placebo-Controlled Study of Risperidone in Adults with Autistic Disorder and Other Pervasive Developmental Disorders', Archives of General Psychiatry 55: 633-41.
15. Mesibov, G.B. & Handlan, S. (1997) 'Adolescentsand AdultswithAutism', in D. J. Cohen & F.R. Volkmar (eds) Handbook of Autism and Pervasive Developmental Disorders, pp. 309-22. New York: Wiley.
16. Nhmrc (2000) How to Use the Evidence: Assessment and Application of Scientific Evidence. Canberra: National Health and Medical Research Council.
17. Nye, C. & Brice, A. (2005) 'Combined Vitamin B6-Magnesium Treatment in Autism Spectrum Disorder', Cochrane Database of Systematic Reviews.
18. Patel, N.C., Yeh, J.Y., Shepherd, M.D. & Crismon, M.L. (2002) 'Secretin Treatment for Autistic Disorder: A Critical Analysis', Pharmacotherapy 22: 905-14.
19. Pfeiffer, S.I., Norton, J., Nelson, L., & Shott, S. (1995) 'Efficacyof Vitamin B6 and Magnesium in the Treatment of Autism: A Methodology Review and Summary of Outcomes', Journal of Autism & Developmental Disorders 25: 481-93.
20. Posey, D.J. & Mcdougle, C.J. (2000) 'ThePharmacotherapyof Target Symptoms Associated with Autistic Disorder and Other Pervasive Developmental Disorders', Harvard Review of Psychiatry 8: 45-63.
21. Posey, D.J. & Mcdougle C.J. (2001) 'Pharmacotherapeutic Managementof Autism', Expert Opinion on Pharmacotherapy 2: 587-600.
22. Rapin, I. (1997) 'Current Concepts: Autism', New England Journal of Medicine 337: 97-104.
23. Remington, G., Sloman, L., Konstantareas, M., Parker, K. & Gow, R. (2001) 'Clomipramine versus Haloperidol in the Treatment of Autistic Disorder: A Double-Blind, Placebo-Controlled, Crossover Study', Journal of Clinical Psychopharmacology 21: 440-4.
24. Rumsey, J.M., Rapoport, J.L. & Sceery, W.R. (1985) 'Autistic Children as Adults: Psychiatric, Social, and Behavioral Outcomes', Journal of the American Academy of Child Psychiatry 24: 465-73.
25. Rutter, M. (1983) 'Cognitive Deficits in the Pathogenesis of Autism', Journal of Child Psychology & Psychiatry & Allied Disciplines 24: 513-31.
26. Scahill, L., Mccracken, J., Mcdougle, C.J., Aman, M., Arnold, L.E., Tierney, E., Cronin, P., Davies, M., Ghuman, J., Gonzalez, N., Koenig, K., Lindsay, R., Martin, A., Mcgough, J., Posey, D.J., Swiezy, N., Volkmar, F., Ritz, L. & Vitiello, B. (2001) 'Methodological Issues in Designing a Multisite Trial of Risperidone in Children and Adolescents with Autism', Journal of Child & Adolescent Psychopharmacology 11: 377-388.
27. Sturme Y, P. (2005) 'Secretin Is an Ineffective Treatment for Pervasive Developmental Disabilities: A Review of 15 Double-Blind Randomized Controlled Trials', Research in Developmental Disabilities 26 (1): 87-97.
28. Tager-Flusberg, H., Joseph, R. & Folstein, S. (2001) 'CurrentDirectionsin Research on Autism', Mental Retardation & Developmental Disabilities Research Reviews 7: 21-9.
29. Toren, P., Laor, N. & Weizman, A. (1998) 'Useof Atypical Neurolepticsin Child and Adolescent Psychiatry', Journal of Clinical Psychiatry 59: 644-56.
30. Tyrer, S.P. & Hill, S.C. (2000) 'PsychopharmacologicalTreatmentsfor Patients with Intellectual Disability', Hong Kong Journal of Psychiatry 10: 16-21.
31. Volkmar, F.R. & Nelson, D.S. (1990) 'Seizure Disorders in Autism', Journal of the American Academy of Child & Adolescent Psychiatry 29: 127-9.
32. Willemsen-Swinkels, S.H.N., Buitelaar, J.K., Nijhof, G.J. & Va N Engeland, H. (1995) 'Failure of Naltrexone Hydrochloride to Reduce Self-Injurious and Autistic Behavior in Mentally Retarded Adults: Double-Blind Placebo-Controlled Studies', Archives of General Psychiatry 52: 766-73.
33. Williams, K.W., Wray, J.J. & Wheeler, D.M. (2006) 'IntravenousSecretinfor Autism Spectrum Disorder', Cochrane Database of Systematic Reviews Issue 4.
34. Zarcone, J.R., Hellings, J.A., Crandall, K., Reese, R.M., Marquis, J., Fleming, K., Shores, R., Williams, D. & Schroeder, S.R. (2001) 'Effectsof Risperidone on Aberrant Behavior of Persons with Developmental Disabilities. I: A Double-Blind Crossover Study Using Multiple Measures', American Journal on Mental Retardation 106: 525-38.