Development and validation of a stereoselective HPLC method for the determination of the in vitro transport of nateglinide enantiomers in rat intestine

Journal of Separation Science

Volumn 30, Issue 12, 2007, Pages 1875-1880

  Maddi, Srinivas ^a,b   Keshetty, Srisailam ^a   Mohan Ega, Chandra ^a   Yamasani, Madhusudan Rao ^a   Scriba, Gerhard K E ^b  

^a KAKATIYA UNIVERSITY   (India)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Chiral HPLC; Chiralcel OJ RH; Intestinal transport; Nateglinide

Indexed keywords

ENANTIOMERS; FLOW RATE; MAMMALS; PH; PHASE COMPOSITION; STEREOSELECTIVITY; TEMPERATURE;

CHROMATOGRAPHIC SEPARATION; INTESTINAL TRANSPORT; NATEGLINIDE;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

NATEGLINIDE; POTASSIUM DIHYDROGEN PHOSPHATE;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALIBRATION; COLUMN CHROMATOGRAPHY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG STRUCTURE; DUODENUM; ENANTIOMER; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ILEUM; IN VITRO STUDY; INTESTINE ABSORPTION; JEJUNUM; LINEAR SYSTEM; MALE; NONHUMAN; PH; PRIORITY JOURNAL; RACEMIC MIXTURE; RAT; SEPARATION TECHNIQUE; STEREOCHEMISTRY; TEMPERATURE; VALIDATION STUDY;

ANIMALS; CALIBRATION; CHROMATOGRAPHY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOHEXANES; HYDROGEN-ION CONCENTRATION; HYPOGLYCEMIC AGENTS; INTESTINES; MALE; PHENYLALANINE; PHOSPHATES; POTASSIUM COMPOUNDS; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; STEREOISOMERISM;

RATTUS;

EID: 34547841417     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200600527     Document Type: Article

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