The ability of a new hypoglycaemic agent, A-4166, compared to sulphonylureas, to increase cytosolic Ca2+ in pancreatic β-cells under metabolic inhibition

British Journal of Pharmacology

Volumn 120, Issue 7, 1997, Pages 1191-1198

  Fujitani, Shoji ^a,b   Okazaki, Kyoko ^b   Yada, Toshihiko ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b AJINOMOTO CO INC   (Japan)

Author keywords

A 4166; Cytosolic Ca2+; Glucose; Metabolic inhibitor; NIDDM; Pancreatic cell; Sulphonylurea

Indexed keywords

2,4 DINITROPHENOL; CALCIUM ION; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; INSULIN; MANNOHEPTULOSE; NATEGLINIDE; ORAL ANTIDIABETIC AGENT; POTASSIUM CYANIDE; SULFONYLUREA; TOLBUTAMIDE;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; GLUCOSE METABOLISM; INSULIN RELEASE; METABOLIC INHIBITION; MICROFLUOROMETRY; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

ANIMALS; CALCIUM; CYCLOHEXANES; CYTOSOL; ELECTRON TRANSPORT; ENZYME INHIBITORS; GLICLAZIDE; GLUCOKINASE; GLUCOSE; HYPOGLYCEMIC AGENTS; ISLETS OF LANGERHANS; MITOCHONDRIA; OXIDATIVE PHOSPHORYLATION; PHENYLALANINE; RATS; RATS, WISTAR; SULFONYLUREA COMPOUNDS; TOLBUTAMIDE;

EID: 0030896114     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701017     Document Type: Article

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