메뉴 건너뛰기




Volumn 34, Issue 6, 2007, Pages 625-631

2-[methyl-11C]Methoxyestradiol: synthesis, evaluation and pharmacokinetics for in vivo studies on angiogenesis

Author keywords

2 methyl 11C Methoxyestradiol; Angiogenesis; HUVECs; Pharmacokinetics

Indexed keywords

2 METHYLMETHOXYESTRADIOL C 11; ESTRADIOL DERIVATIVE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

EID: 34547830386     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2007.06.004     Document Type: Article
Times cited : (13)

References (20)
  • 1
    • 0016429845 scopus 로고
    • Tumor angiogenesis: a possible control point in tumor growth
    • Folkman J. Tumor angiogenesis: a possible control point in tumor growth. Ann Intern Med 82 (1975) 96-100
    • (1975) Ann Intern Med , vol.82 , pp. 96-100
    • Folkman, J.1
  • 2
    • 0029121235 scopus 로고
    • Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects
    • Battegay E.J. Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects. J Mol Med 73 (1995) 333-346
    • (1995) J Mol Med , vol.73 , pp. 333-346
    • Battegay, E.J.1
  • 3
    • 0028220858 scopus 로고
    • The endogenous oestrogen metabolite 2-methoxyestradiol inhibits angiogenesis and suppresses tumor growth
    • Fotsis T., Zhang Y., Pepper M.S., Adlercreutz H., Montesano R., Nawroth P.P., et al. The endogenous oestrogen metabolite 2-methoxyestradiol inhibits angiogenesis and suppresses tumor growth. Nature 368 (1994) 237-239
    • (1994) Nature , vol.368 , pp. 237-239
    • Fotsis, T.1    Zhang, Y.2    Pepper, M.S.3    Adlercreutz, H.4    Montesano, R.5    Nawroth, P.P.6
  • 4
    • 0031015504 scopus 로고    scopus 로고
    • Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and Taxol
    • Klauber N., Parangi S., Flynn E., Hamel E., and D'Amato R.J. Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and Taxol. Cancer Res 57 (1997) 81-86
    • (1997) Cancer Res , vol.57 , pp. 81-86
    • Klauber, N.1    Parangi, S.2    Flynn, E.3    Hamel, E.4    D'Amato, R.J.5
  • 5
    • 0031037067 scopus 로고    scopus 로고
    • Induction of apoptosis in human lung cancer cells after wild-type p53 activation by methoxyestradiol
    • Mukhopadhyay T., and Roth J.A. Induction of apoptosis in human lung cancer cells after wild-type p53 activation by methoxyestradiol. Oncogene 14 (1997) 379-384
    • (1997) Oncogene , vol.14 , pp. 379-384
    • Mukhopadhyay, T.1    Roth, J.A.2
  • 7
    • 0028331925 scopus 로고
    • 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicines site
    • D'Amato R.J., Lin C.M., Flynn E., Folkman J., and Hamel E. 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicines site. Proc Natl Acad Sci U S A 91 (1994) 3964-3968
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 3964-3968
    • D'Amato, R.J.1    Lin, C.M.2    Flynn, E.3    Folkman, J.4    Hamel, E.5
  • 8
    • 0029008622 scopus 로고
    • Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site
    • Cushman M., He H.-M., Katzenellenbogen J.A., Lin C.M., and Hamel E. Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site. J Med Chem 38 (1995) 2041-2049
    • (1995) J Med Chem , vol.38 , pp. 2041-2049
    • Cushman, M.1    He, H.-M.2    Katzenellenbogen, J.A.3    Lin, C.M.4    Hamel, E.5
  • 9
    • 0034699513 scopus 로고    scopus 로고
    • Superoxide dismutase as a target for the selective killing of cancer cells
    • Huang P., Feng L., Oldham E.A., Keating M.J., and Plunkett W. Superoxide dismutase as a target for the selective killing of cancer cells. Nature 407 (2000) 390-395
    • (2000) Nature , vol.407 , pp. 390-395
    • Huang, P.1    Feng, L.2    Oldham, E.A.3    Keating, M.J.4    Plunkett, W.5
  • 10
    • 0742269867 scopus 로고    scopus 로고
    • New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent
    • Mooberry S.L. New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent. Curr Opin Oncol 15 (2003) 425-430
    • (2003) Curr Opin Oncol , vol.15 , pp. 425-430
    • Mooberry, S.L.1
  • 11
    • 32544433479 scopus 로고    scopus 로고
    • Phase I clinical trial of oral 2-methoxyestradiol, an antiangiogenic and apoptotic agent, in patients with solid tumors
    • Dahut W.L., Lakhani N.J., Gulley J.L., Arlen P.M., Kohn E.C., Kotz H., et al. Phase I clinical trial of oral 2-methoxyestradiol, an antiangiogenic and apoptotic agent, in patients with solid tumors. Cancer Biol Ther 5 (2006) 22-27
    • (2006) Cancer Biol Ther , vol.5 , pp. 22-27
    • Dahut, W.L.1    Lakhani, N.J.2    Gulley, J.L.3    Arlen, P.M.4    Kohn, E.C.5    Kotz, H.6
  • 12
    • 1642319678 scopus 로고    scopus 로고
    • Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents
    • Ireson C.R., Chander S.K., Purohit A., Perera S., Newman S.P., Parish D., et al. Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents. Br J Cancer 90 (2004) 932-937
    • (2004) Br J Cancer , vol.90 , pp. 932-937
    • Ireson, C.R.1    Chander, S.K.2    Purohit, A.3    Perera, S.4    Newman, S.P.5    Parish, D.6
  • 13
    • 25144452785 scopus 로고    scopus 로고
    • A phase II multicenter, randomized, double-blind, safety trial assessing the pharmacokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in hormone-refractory prostate cancer
    • Sweeney C., Liu G., Yiannoutsos C., Kolesar J., Horvath D., Staab M.J., et al. A phase II multicenter, randomized, double-blind, safety trial assessing the pharmacokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in hormone-refractory prostate cancer. Clin Cancer Res 11 (2005) 6625-6633
    • (2005) Clin Cancer Res , vol.11 , pp. 6625-6633
    • Sweeney, C.1    Liu, G.2    Yiannoutsos, C.3    Kolesar, J.4    Horvath, D.5    Staab, M.J.6
  • 14
    • 0037764867 scopus 로고    scopus 로고
    • Short synthesis of 2-methoxyestradiol and 2-hydroxyestradiol
    • Kiuru P.S., and Wähälä K. Short synthesis of 2-methoxyestradiol and 2-hydroxyestradiol. Steroids 68 (2003) 373-375
    • (2003) Steroids , vol.68 , pp. 373-375
    • Kiuru, P.S.1    Wähälä, K.2
  • 15
    • 27144538223 scopus 로고    scopus 로고
    • Distribution and pharmacokinetic analysis of angiostatin radioiodine labeled with high stability
    • Song S.H., Jung K.H., Paik J.Y., Koh B.H., Bae J.S., Choe Y.S., et al. Distribution and pharmacokinetic analysis of angiostatin radioiodine labeled with high stability. Nucl Med Biol 32 (2005) 845-850
    • (2005) Nucl Med Biol , vol.32 , pp. 845-850
    • Song, S.H.1    Jung, K.H.2    Paik, J.Y.3    Koh, B.H.4    Bae, J.S.5    Choe, Y.S.6
  • 16
    • 33751428733 scopus 로고    scopus 로고
    • Pharmacokinetics and biodistribution of a small radioiodine labeled nerve growth factor fragment
    • Jung K.H., Kim D.H., Paik J.Y., Ko B.H., Bae J.S., Choe Y.S., et al. Pharmacokinetics and biodistribution of a small radioiodine labeled nerve growth factor fragment. Ann Nucl Med 20 (2006) 535-540
    • (2006) Ann Nucl Med , vol.20 , pp. 535-540
    • Jung, K.H.1    Kim, D.H.2    Paik, J.Y.3    Ko, B.H.4    Bae, J.S.5    Choe, Y.S.6
  • 17
    • 34547831094 scopus 로고    scopus 로고
    • Paaren HE, Duff SR. Synthesis of 2-hydroxyestradiol derivatives. US Patent 6448419, September 10, 2002.
  • 19
    • 0035003282 scopus 로고    scopus 로고
    • Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action
    • Takaku T., Kimura Y., and Okuda H. Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action. J Nutr 131 (2001) 1409-1413
    • (2001) J Nutr , vol.131 , pp. 1409-1413
    • Takaku, T.1    Kimura, Y.2    Okuda, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.