Identification of critical residues in nervous necrosis virus B2 for dsRNA-binding and RNAi-inhibiting activity through by bioinformatic analysis and mutagenesis

Biochemical and Biophysical Research Communications

Volumn 361, Issue 3, 2007, Pages 634-640

  Ou, Ming Chang ^a   Chen, Young Mao ^a   Jeng, Mei Fen ^a   Chu, Chiau Jun ^b   Yang, Huey Lang ^a   Chen, Tzong Yueh ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b DEPARTMENT OF HEALTH   (Taiwan)

Author keywords

B2 protein; Betanodavirus; Orange spotted grouper

Indexed keywords

AMINO ACID; ARGININE; B2 PROTEIN; DOUBLE STRANDED RNA; GLUTAMINE; MUTANT PROTEIN; NONSTRUCTURAL PROTEIN 3; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; BINDING ASSAY; BIOINFORMATICS; CONTROLLED STUDY; FEMALE; GENE CONTROL; GENE REPRESSION; HELA CELL; HUMAN; HUMAN CELL; MOLECULAR MODEL; MUTATIONAL ANALYSIS; NERVOUS NECROSIS VIRUS; NODAVIRUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; PROTEIN RNA BINDING; PROTEIN STRUCTURE; RNA INTERFERENCE; SITE DIRECTED MUTAGENESIS; VIRUS CELL INTERACTION; VIRUS GENOME;

AMINO ACID SEQUENCE; ANIMALS; ARGININE; BINDING SITES; COMPUTATIONAL BIOLOGY; FISHES; HELA CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NODAVIRIDAE; PROTEIN CONFORMATION; RNA INTERFERENCE; RNA, DOUBLE-STRANDED; SEQUENCE ALIGNMENT; VIRAL PROTEINS;

ALPHANODAVIRUS; ATLANTIC HALIBUT NODAVIRUS; BETANODAVIRUS; EPINEPHELUS COIOIDES; FLOCK HOUSE VIRUS; STRIPED JACK NERVOUS NECROSIS VIRUS;

EID: 34547828851     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.07.075     Document Type: Article

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