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Volumn , Issue 23, 2007, Pages 3863-3869

Selective synthesis of unnatural α-, β- and γ-amino esters

Author keywords

Amino esters; Asymmetric reductive amination; Heterogeneous hydrogenation

Indexed keywords


EID: 34547815132     PISSN: 1434193X     EISSN: 10990690     Source Type: Journal    
DOI: 10.1002/ejoc.200700345     Document Type: Article
Times cited : (13)

References (60)
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    • For α-amino acids, see: a) W. Zhang, X. Zhang, J. Org. Chem. 2007, 72, 1020-1023;
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    • For a brief summary of the use of Raney-Ni for imine reduction and reductive amination applications, see the text and references within: T. C. Nugent, V. N. Wakchaure, A. K. Ghosh, R. R. Mohanty, Org. Lett. 2005, 7, 4967-4970
    • For a brief summary of the use of Raney-Ni for imine reduction and reductive amination applications, see the text and references within: T. C. Nugent, V. N. Wakchaure, A. K. Ghosh, R. R. Mohanty, Org. Lett. 2005, 7, 4967-4970.
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    • 4 are, e.g., carbamates, urethanes, secondary and tertiary amides, acetonides, silyl ethers, and most esters, see: a) F. E. Janssens, F. M. Sommen, J. E. Leenaerts, Y. E. M. Van Roosbroeck, T. F. Meert (Janssen Pharmaceutica N. V.), Combinations for opioid based treatment of pain comprising 1-(1,2-disubstituted piperidinyl)-4-substituted piperazine derivatives, WO2004110451, 2004;
    • 4 are, e.g., carbamates, urethanes, secondary and tertiary amides, acetonides, silyl ethers, and most esters, see: a) F. E. Janssens, F. M. Sommen, J. E. Leenaerts, Y. E. M. Van Roosbroeck, T. F. Meert (Janssen Pharmaceutica N. V.), Combinations for opioid based treatment of pain comprising 1-(1,2-disubstituted piperidinyl)-4-substituted piperazine derivatives, WO2004110451, 2004;
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    • [14], we obtained a 52% de (major diastereomer: 19.1 min; minor diastereomer: 18.7 min) using program A of the Experimental Section (General).
    • [14], we obtained a 52% de (major diastereomer: 19.1 min; minor diastereomer: 18.7 min) using program A of the Experimental Section (General).


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