The protean neurologic manifestations of varicella-zoster virus infection

Cleveland Clinic Journal of Medicine

Volumn 74, Issue 7, 2007, Pages 489-504

  Nagel, Maria A ^a   Gilden, Donald H ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 34547794624     PISSN: 08911150     EISSN: None     Source Type: Journal    
DOI: 10.3949/ccjm.74.7.489     Document Type: Review

References (107)

1. Harnisch JP. Zoster in the elderly: clinical, immunologic and therapeutic considerations. J Am Geriatr Soc 1984; 32:789-793.
2. Gilden DH, Cohrs RJ, Mahalingam R. Clinical and molecular pathogenesis of varicella virus infection. Viral Immunol 2003; 16:243-258.
3. Leppard B, Naburi AE. Herpes zoster: an early manifestation of HIV infection. Afr Health 1998; 21:5-6.
4. Kakourou T, Theodorklou M, Mostrou G, Syriopoulou V, Papadogeorgaki H, Constantopoulos A. Herpes zoster in children. J Am Acad Dermatol 1998; 39:207-210.
5. Gold E. Serologic and virus-isolation studies of patients with varicella or herpes-zoster infection. N Engl J Med 1966; 274:181-185.
6. Head H, Campbell AW, Kennedy PG. The pathology of herpes zoster and its bearing on sensory localisation. Rev Med Virol 1997; 7:131-143.
7. Denny-Brown D, Adems RD, Fitzgerald PJ. Pathologic features of herpes zoster: a note on "geniculate herpes." Arch Neurol Psychiatry 1944; 51:216-231.
8. Cheatham WJ, Dolan TF Jr, Dower JC, Weller TH. Varicella: report of two fatal cases with necropsy, virus isolation, and serologic studies. Am J Pathol 1956; 32:1015-1035.
9. Ghatak NR, Zimmerman HM. Spinal ganglion in herpes zoster. A light and electron microscopic study. Arch Pathol 1973; 95:411-415.
10. Esiri MM, Tomlinson AH. Herpes zoster. Demonstration of virus in trigeminal nerve and ganglion by immunofluorescence and electron microscopy. J Neurol Sci 1972; 15:35-48.
11. Nagashima K, Nakazawa M, Endo H. Pathology of the human spinal ganglia in varicella-zoster virus infection. Acta Neuropathol (Berl) 1975; 33:105-117.
12. Blumenthal DT, Salzman KL, Baringer JR, Forghani B, Gilden DH. MRI abnormalities in chronic active varicella zoster infection. Neurology 2004; 63:1538-1539.
13. Carroll WM, Mastaglia FL. Optic neuropathy and ophthalmoplegia in herpes zoster oticus. Neurology 1979; 29:726-729.
14. Meenken C, van den Hom GJ, de Smet MD, van der Meer JT. Optic neuritis heralding varicella zoster virus retinitis in a patient with acquired immunodeficiency syndrome. Ann Neurol 1998; 43:534-536.
15. Archambault P, Wise JS, Rosen J, Polomeno RC, Auger N. Herpes zoster ophthalmoplegia. Report of six cases. J Clin Neuroophthalmol 1988; 8:185-193.
16. Sodhi PK, Goel JL. Presentations of cranial nerve involvement in two patients with herpes zoster ophthalmicus. J Commun Dis 2001; 33:130-135.
17. Karmon Y, Gadoth N. Delayed oculomotor nerve palsy after bilateral cervical zoster in an immunocompetent patient. Neurology 2005; 65:170.
18. Manz HJ, Center HG, Malton J. Trigeminal herpes zoster causing mandibular osteonecrosis and spontaneous tooth exfoliation. South Med J 1986; 79:1026-1028.
19. Garty BZ, Dinari G, Sarnat H, Cohen S, Nitzan M. Tooth exfoliation and osteonecrosis of the maxilla after trigeminal herpes zoster. J Pediatr 1985; 106:71-73.
20. Volvoikar P, Patil S, Dinkar A. Tooth exfoliation, osteonecrosis and neuralgia following herpes zoster of trigeminal nerve. Indian J Dent Res 2002; 13:11-14.
21. Sweeney CJ, Gilden DH. Ramsay Hunt syndrome. J Neurol Neurosurg Psychiatry 2001; 71:149-154.
22. Asnis DS, Mick L, Giaccio D. Ramsay Hunt syndrome presenting as a cranial polyneuropathy. Cutis 1996; 57:421-424.
23. Robillard RB, Hilsinger RL Jr, Adour KK. Ramsay Hunt facial paralysis: clinical analyses of 185 patients. Otolaryngol Head Neck Surg 1986; 95:292-297.
24. Furuta Y, Ohtani F, Aizawa H, Fukuda S, Kawabata H, Bergstrom I. Varicella-zoster virus reactivation is an important cause of acute peripheral facial paralysis in children. Pediatr Infect Dis J 2005; 24:97-101.
25. Merchut MP, Gruener G. Segmental zoster paresis of limbs. Electromyogr Clin Neurophysiol 1996; 36:369-375.
26. Yoleri O, Olmez N, Oztura I, Sengul I, Gunaydin R, Memis A. Segmental zoster paresis of the upper extremity: a case report. Arch Phys Med Rehabil 2005; 86:1492-1494.
27. Anderson JP, Keal EE. Cervical herpes zoster and diaphragmatic paralysis. Br J Dis Chest 1969; 63:222-226.
28. Tjandra J, Mansel RE. Segmental abdominal herpes zoster paresis. Aust N Z J Surg 1986; 56:807-808.
29. Murakami S, Hato N, Horiuchi J, Honda N, Gyo K, Yanagihara N. Treatment of Ramsay Hunt syndrome with acyclovir-prednisone: significance of early diagnosis and treatment. Ann Neurol 1997; 41:353-357.
30. Furuta Y, Ohtani F, Mesuda Y, Fukuda S, Inuyama Y. Early diagnosis of zoster sine herpete and antiviral therapy for the treatment of facial palsy. Neurology 2000; 55:708-710.
31. Rogers RS 3rd, Tindall JP. Herpes zoster in the elderly. Postgrad Med 1971; 50:153-157.
32. Vafai A, Wellish M, Gilden DH. Expression of varicella-zoster virus in blood mononuclear cells of patients with postherpetic neuralgia. Proc Natl Acad Sci USA 1988; 85:2767-2770.
33. Devlin ME, Gilden DH, Mahalingam R, Dueland AN, Cohrs R. Peripheral blood mononuclear cells of the elderly contain varicella-zoster virus DNA. J Infect Dis 1992; 165:619-622.
34. Mahalingam R, Wellish M, Brucklier J, Gilden DH. Persistence of varicellazoster virus DNA in elderly patients with postherpetic neuralgia. J Neurovirol 1995; 1:130-133.
35. Terada K, Niizuma T, Kawano S, Kataoke N, Akisada T, Orita Y. Detection of varicella-zoster virus DNA in peripheral mononuclear cells from patients with Ramsay Hunt syndrome or zoster sine herpete. J Med Virol 1998; 56:359-363.
36. Gilden DH, Cohrs RJ, Hayward AR, Wellish M, Mahalingam R. Chronic varicella-zoster virus ganglionitis - a possible cause of postherpetic neuralgia. J Neurovirol 2003; 9:404-407.
37. Quan D, Hammade BN, Kittelson J, Gilden DH. Improvement of postherpetic neuralgia after treatment with intravenous acyclovir followed by oral valacyclovir. Arch Neurol 2006; 63:940-942.
38. Rowbotham M, Harden N, Stacey B, Bernstein P, Magnus-Miller L. Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. JAMA 1998; 280:1837-1842.
39. Rice AS, Maton S; Postperpetic Neuralgia Study Group. Gabapentin in postherpetic neuralgia: a randomised, double blind, placebo controlled study. Pain 2001; 94:215-224.
40. Gilron I, Bailey JM, Tu D, Holden RR, Weaver DF, Houlden RL. Morphine, gabapentin, or their combination for neuropathic pain. N Engl J Med 2005; 352:1324-1334.
41. Dubinsky RM, Kabbani H, El-Chami Z, Boutwell C, Ali H; Quality Standards Subcommittee of the American Academy of Neurology. Practice parameter: treatment of postherpetic neuralgia: an evidence-based report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2004; 63:959-965.
42. Rowbotham MC, Manville NS, Ren J. Pilot tolerability and effectiveness study of levetiracetam for postherpetic neuralgia. Neurology 2003; 61:866-867.
43. Huff JC. Antiviral treatment in chickenpox and herpes zoster. J Am Acad Dermatol 1988; 18:204-206.
44. Beutner KR, Friedman DJ, Forszpaniak C, Andersen PL, Wood MJ. Valaciclovir compared with acyclovir for improved therapy for herpes zoster in immunocompetent adults. Antimicrob Agents Chemother 1995; 39:1546-1553.
45. Tyring S, Barbarash RA, Nahlik JE, et al. Famciclovir for the treatment of acute herpes zoster: effects on acute disease and postherpetic neuralgia. A randomized, double-blind, placebo-controlled trial. Collaborative Famciclovir Herpes Zoster Study Group. Ann Intern Med 1995; 123:89-96.
46. Nau R, Lantsch M, Stiefel M, Polak T, Reiber H. Varicella zoster virus-associated focal vasculitis without herpes zoster: recovery after treatment with acyclovir. Neurology 1998; 51:914-915.
47. Gilden DH, Bennett JL, Kleinschmidt-DeMasters BK, Song DD, Yee AS, Steiner I. The value of cerebrospinal fluid antiviral antibody in the diagnosis of neurologic disease produced by varicella zoster virus. J Neurol Sci 1998; 159:140-144.
48. Gilden DH, Lipton HL, Wolf JS, et al. Two patients with unusual forms of varicella-zoster virus vasculopathy, N Engl J Med 2002; 347:1500-1503.
49. Fukumoto S, Kinjo M, Hokamura K, Tanaka K. Subarachnoid hemorrhage and granulomatous angiitis of the basilar artery: demonstration of the varicella-zoster-virus in the basilar artery lesions. Stroke 1986; 17:1024-1028.
50. O'Donohue JM, Enzmann DR. Mycotic aneurysm in angiitis associated with herpes zoster ophthalmicus. AJNR Am J Neuroradiol 1987; 8:615-619.
51. Burgoon MP, Hammack BN, Owens GP, Maybach AL, Eikelenboom MJ, Gilden DH. Oligodonal immunoglobulins in cerebrospinal fluid during varicella zoster virus (VZV) vasculopathy are directed against VZV. Ann Neurol 2003; 54:459-463.
52. Gilden DH, Kleinschmidt-DeMasters BK, Wellish M, Hedley-Whyte ET, Rentier B, Mahalingam R. Varicella zoster virus, a cause of waxing and waning vasculitis: the New England Journal of Medicine case 5-1995 revisited. Neurology 1996; 47:1441-1446.
53. Nagel MA, Forghani B, Mahalingham R, et al. The value of detecting anti-VZV IgG antibody in CSF to diagnose VZV vasculopathy. Neurology 2007; 68:1069-1073.
54. Ryder JW, Croen K, Kleinschmidt-DeMasters BK, Ostrove JM, Straus SE, Cohn DL. Progressive encephalitis three months after resolution of cutaneous zoster in a patient with AIDS. Ann Neurol 1986; 19:182-188.
55. Aurelius E, Johansson B, Skoldenberg B, Staland A, Forsgren M. Rapid diagnosis of herpes simplex encephalitis by nested polymerase chain reaction assay of cerebrospinal fluid. Lancet 1991; 337:189-192.
56. Hilt DC, Buchholz D, Krumholz A, Weiss H, Wolinsky JS. Herpes zoster ophthalmicus and delayed contralateral hemiparesis caused by cerebral angiitis: diagnosis and management approaches. Ann Neurol 1983; 14:543-553.
57. Pina MA, Ara JR, Capablo JL, Omenaca M. Myelitis and optic neuritis caused by varicella [in Spanish]. Rev Neurol 1997; 25:1575-1576.
58. Celik Y, Tabak F, Mert A, Celik AD, Aktuglu Y. Transverse myelitis caused by varicella. Clin Neurol Neurosurg 2001; 103:260-261.
59. Gilden DH, Beinlich BR, Rubinstien EM, et al. Varicella-zoster virus myelitis: an expanding spectrum. Neurology 1994; 44:1818-1823.
60. Kleinschmidt-DeMasters BV, Gilden DH. Varicella-zoster virus infections of the nervous system: clinical and pathologic correlates. Arch Pathol Lab Med 2001; 125:770-780.
61. Devinsky O, Cho ES, Petito CK, Price RW. Herpes zoster myelitis. Brain 1991; 114:1181-1196.
62. de Silva SM. Mark AS, Gilden DH, et al. Zoster myelitis: improvement with antiviral therapy in two cases. Neurology 1996; 47:929-931.
63. Chua HC, Tjia H, Sitoh YY. Concurrent myelitis and Guillain-Barré syndrome after varicella infection. Int J Clin Pract 2001; 55:643-644.
64. Schvoerer E, Frechin V, Warter A, et al. Persistent multiple pulmonary nodules in a nonimmunocompromised woman after varicel-la-related myelitis treated with acyclovir. J Clin Microbiol 2003; 41:4904-4905.
65. Soushi S, Ozawa H, Matsuhashi M, Shimazaki J, Saga U. Kurata T. Demonstration of varicella-zoster virus antigens in the vitreous aspirates of patients with acute retinal necrosis syndrome. Ophthalmology 1988; 95:1394-1398.
66. Thompson WS, Culbertson WW, Smiddy WE, Robertson JE, Rosenbaum JT. Acute retinal necrosis caused by reactivation of herpes simplex virus type 2. Aim J Ophthalmol 1994; 118:205-211.
67. Tan JCH, Byles D, Stanford MR, Frith PA, Graham EM. Acute retinal necrosis in children caused by herpes simplex virus. Retina 2001; 21:344-347.
68. Holland GN. The progressive outer retinal necrosis syndrome. Int Ophthalmol 1994; 18:163-165.
69. Bonfioli AA, Eller AW. Acute retinal necrosis. Semin Ophthalmol 2005; 20:155-160.
70. Savant V, Saeed T, Denniston A, Murray PI. Oral valganciclovir treatment of varicella zoster virus acute retinal necrosis. Eye 2004, 18:544-545.
71. Engstrom RE Jr, Holland GN, Margolis TP, et al. The progressive outer retinal necrosis syndrome. A variant of necrotizing herpetic retinopathy in patients with AIDS. Ophthalmology 1994; 101:1488-1502.
72. Guex-Crosier Y, Rochat C, Herbort CP. Necrotizing herpetic retinopathies. A spectrum of herpes virus-induced diseases determined by the immune state of the host. Ocul Immunol Inflamm 1997; 5:259-265.
73. Lewis JM, Nagae Y, Tano Y. Progressive outer retinal necrosis after bone marrow transplantation. Am J Ophthalmol 1996; 122:892-895.
74. Franco-Paredes C, Bellehemeur T, Merchant A. Sanghi P, DiazGranados C. Rimland D. Aseptic meningitis and optic neuritis preceding varicella-zoster progressive outer retinal necrosis in a patient with AIDS. AIDS 2002; 16:1045-1049.
75. Menerath JM, Gerard M, Laurichesse H, et al. Bilateral acute retinal necrosis in a patient with acquired immunodeficiency syndrome [in French]. J Fr Ophtalmol 1995; 18:625-633.
76. Tran TH, Rozenberg F, Cassoux N, Rao NA, LeHoang P, Bodaghi B. Polymerase chain reaction analysis of aqueous humour samples in necrotising retinitis. Br J Ophthalmol 2003; 87:79-83.
77. Margolis TP, Lowder CY, Holland GN, et al. Varicella-zoster virus retinitis in patients with the acquired immunodeficiency syndrome: Am J Ophthalmol 1991; 112:119-131.
78. van den Hom GJ, Meenken C, Troost D. Association of progressive outer retinal necrosis and varicella zoster encephalitis in a patient with AIDS. br J Ophthalmol 1996; 80:982-985.
79. Kashiwase M, Sate T, Yamauchi Y, et al. Progressive outer retinal necrosis caused by herpes simplex virus type 1 in a patient with acquired immunodeficiency syndrome. Ophthalmology 2000; 107:790-794.
80. Biswas J, Choudhry S, Priya K, Gopal L. Detection of cytomegalovirus from vitreous humor in a patient with progressive outer retinal necrosis. Indian J Ophthalmol 2002; 50:319-321.
81. Johnston WH, Holland GN, Engstrom RE Jr. Rimmer S. Recurrence orf presumed varicella-zoster virus reftopathy in patients with acquired immuno-defidency syndrome. Am J Ophthalmoll 1993; 116:42-50.
82. Moorthy RS, Weinberg DV, Teich SA, et al. Management of varicella zoster virus retinitis in AIDS. Br J Ophthalmol 1997; 81:189-194.
83. Dullaert H, Maudgal PC, Leys A, Dralands L, Clercq E. Bromovinyldeoxyuridine treatment of outer retinal necrosis due to varicella-zoster virus: a caw-report. Bull Soc Belge Ophtalmol 1996; 262:107-113.
84. Austin RB. Progressive outer retinal necrosis syndrome: a comprehensive review of its clinical presentation, relationship to immune system status, and management. Clin Eye Vis Care 2000; 11:119-129.
85. Lewis GW. Zoster sine herpete. Bir Med J 1958; 2:418-421.
86. Easton HG. Zoster sine herpete causing acute trigeminal neuralgia. Lancet 1970; 2:1065-1066.
87. Schott GD. Triggering of delayed-onset postherpetic neuralgia. Lancet. 1998, 351:419-420.
88. Gilden DH, Wright RR, Schneck SAn Gwaltney JM, Jr Mahalingam R. Zoster sine herpete, a clinical variant Ann Neurol 1994, 35:530-533.
89. Amlie-Lefond C, Mackin GA, Ferguson M, Wright RR, Mahalingam R, Gilden DH. Another case of virologically confirmed zoster sine herpete, with electrophysiologic correlation. J Neurovirol 1996, 2:136-138.
90. Powell KF, Wilson HG, Croxson MO. et al. Herpes zoster meningoen-cephalitis without rash: varicella zoster virus DNA in CSF. J Neurol Neurosurg Psychiatry 1995, 59:198-199.
91. Mancardi GL, Meliolli G, Traverso F, Tabaton M, Farinelli M, Terragna A. Zoster sine herpete causing encephalomyelitis. Ital J Neurol Sci 1997; 8:67-70.
92. Kleinschmidt-DeMasters BK, Mahalingam R, Shimek C, et al. Profound cerebrospinal fluid pleorytosis and Froin's syndrome secondary to widespread necrotizing vasculitis in an HIV-positive patient with varicella zoster virus encephalomyelitis. J Neurol Sci 1998, 159:213-218.
93. Connolly AM, Dodson WE, Prensky, AL, Rust RS. Course and outcome of acute cerebellar ataxia. Ann Neurol 1994; 35:673-679.
94. Dangond F, Engle E, Yessayan L, Sawyer MH. Pre-eruptive varicella cerebellitis confirmed by PCR. Pediatr Neurol 1993; 9:491-493.
95. Ratzka P, Schlachetzki JC, Bahr M, Nau R. Varicella zoster virus cerebellitis in a 66-year-old patient without herpes zoster. Lancet 2006; 367:182.
96. Funakawa I, Terao A, Koga M. A case of zoster sine herpete with involvement of the unilateral IX, X and XI cranial and upper cervical nerves [in Japanese]. Rinsho Shinkeigaku 1999, 39:958-960.
97. Goon P, Wright M, Fink VC. Ophthalmic zoster sine herpete. J R Soc Med 2000; 93:191-192.
98. Hon C, Au WY, Cheng VC. Ophthalmic zoster sine herpete presenting as oculomator palsy after marrow transplantation for acute myeloid leukemia. Haematologica 2005; 90(12 suppl):EIM04.
99. Noda Y, Nakazawa M, Takahashi D, Tsuruya T, Saito M, Sekine M. Retinal periphlebitis as zoster sine herpete. Arch Ophthalmol 2001; 119:1550-1552.
100. Akpek EK, Gottsch JD. Herpes zoster sine herpete presenting with hyphema. Ocul Immunol Inflamm 2000; 8:115-118.
101. Yamamoto S, Tada R, Shimomura Y, Pavan-Langston D, Dunkel EC, Tano Y. Detecting varicella-zoster virus DNA in iridocyclitis using polymerase chain reaction: a case of zoster sine herpete. Arch Ophthalmol 1995; 113:13S8-1359.
102. Silverstein BE, Chandler D, Neger R, Margolis TP. Disciform keratitis: a case of herpes zoster sine herpete. Am J Ophthalmol 1997; 123:254-255.
103. Dueland AN, Devlin M, Martin JR, et al. Fatal varicella-zoster virus meningoradiculitis without skin involvement. Ann Neurol 1991; 29:569-572.
104. Hevner P, Vilela M, Rostorally R, et al. An unusual cause of trigeminal-distribution pain and tumour. Lancet Neurol 2003; 2:567-571.
105. Oxman MN, Levin MJ, Johnson GR, et al; Shingles Prevention Study Group A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N Engi J Med 2005; 352:2271-2284.
106. Donahue JG, Choo PW, Manson JE, Platt R. The incidence of herpes zoster. Arch Intern Med 1995; 155:1605-1609.
107. U.S. Census Bureau. U.S. Interim Projections by Age, Sex; Rim, and Hispanic Origin. U.S. Census Bureau; 2004. http://www.census.gov/ipc/www/usinterimproj.