Poorer results of mice with latent toxoplasmosis in learning tests: Impaired learning processes or the novelty discrimination mechanism?

Parasitology

Volumn 134, Issue 10, 2007, Pages 1329-1337

  Hodkova, H ^a   Kodym, P ^b   Flegr, J ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b NATIONAL INSTITUTE OF PUBLIC HEALTH   (Czech Republic)

Author keywords

Dopamine; Latent toxoplasmosis; Manipulation hypothesis; Novelty seeking; Parasite; Toxoplasma

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL PARASITOSIS; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; CONTROLLED STUDY; DISCRIMINATION LEARNING; DISEASE COURSE; EXPERIMENTAL TEST; FEMALE; INOCULATION; LEARNING DISORDER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCORING SYSTEM; TOXOPLASMA GONDII;

ANIMALS; BEHAVIOR, ANIMAL; FEMALE; LEARNING; MAZE LEARNING; MICE; MICE, INBRED BALB C; MOTOR ACTIVITY; TOXOPLASMA; TOXOPLASMOSIS, ANIMAL;

ANIMALIA; FELIDAE; MUS; PROTOZOA; RODENTIA; TOXOPLASMA; TOXOPLASMA GONDII;

EID: 34547786063     PISSN: 00311820     EISSN: 14698161     Source Type: Journal    
DOI: 10.1017/S0031182007002673     Document Type: Article

References (40)

1. Alonso, R., Chaudieu, I., Diorio, J., Krishnamurthy, A., Quirion, R. and Boksa, P. (1993). Interleukin-2 modulates evoked release of [3H]dopamine in rat cultured mesencephalic cells. Journal of Neurochemistry 61, 1284-1290.
2. Bachmann, S., Schroder, J., Bottmer, C., Torrey, E. F. and Yolken, R. H. (2005). Psychopathology in first-episode schizophrenia and antibodies to Toxoplasma gondii. Psychopathology 38, 87-90.
3. Berdoy, M., Webster, J. P. and Macdonald, D. W. (1995). Parasite-altered behaviour: is the effect of Toxoplasma gondii on Rattus norvegicus specific? Parasitology 111, 403-409.
4. Creese, I., Burt, D. R. and Snyder, S. H. (1976). Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science 192, 481-483.
5. Dellu, F., Piazza, P. V., Mayo, W., LeMoal, M. and Simon, H. (1996). Novelty-seeking in rats - Biobehavioral characteristics and possible relationship with the sensatin-seeking trait in man. Neuropsychobiology 34, 136-145.
6. Flegr, J. (2007). Effects of Toxoplasma on human behavior. Schizophrenia Bulletin PMID: 17218612.
7. Flegr, J., Hruskova, M., Hodny, Z., Novotna, M. and Hanusova, J. (2005). Body height, body mass index, waist-hip ratio, fluctuating asymmetry and second to fourth digit ratio in subjects with latent toxoplasmosis. Parasitology 130, 621-628.
8. Flegr, J., Preiss, M., Klose, J., Havliček, J., Vitáková, M. and Kodym, P. (2003). Decreased level of psychobiological factor novelty seeking and lower intelligence in men latently infected with the protozoan parasite Toxoplasma gondii. Dopamine, a missing link between schizophrenia and toxoplasmosis? Biological Psychology 63, 253-268.
9. Gross, U. (1996). Toxoplasma gondii research in Europe. Parasitology Today 12, 1-4.
10. Hay, J., Aitken, P. P. and Arnott, M. A. (1985). The influence of Toxoplasma infection on the spontaneous running activity of mice. Zeitschrift für Parasitenkunde 71, 459-462.
11. Hay, J., Aitken, P. P. and Graham, D. I. (1984). Toxoplasma infection and response to novelty in mice. Zeitschrift für Parasitenkunde 70, 575-588.
12. Hay, J., Hutchison, W. M., Aitken, P. P. and Graham, D. I. (1983). The effect of congenital and adult-acquired Toxoplasma infections on activity and responsiveness to novel stimulation in mice. Annals of Tropical Medicine and Parasitology 77, 483-495.
13. Holliman, R. E. (1997). Toxoplasmosis, behaviour and personality. Journal of Infection 35, 105-110.
14. Holmes, J. and Bethel, W. M. (1972). Modification of intermidiate host behaviour by parasites. In Behavioural Aspects of Parasite Transmission (ed. Canning, E. U. and Wright, C. A.), pp. 123-149. Academic Press, London.
15. Hrdá, S., Votypka, J., Kodym, P. and Flegr, J. (2000). Transient nature of Toxoplasma gondii-induced behavioral changes in mice. Journal of Parasitology 86, 657-663.
16. Hubscher, C. H., Brooks, D. L. and Johnson, J. R. (2005). A quantitative method for assessing stages of the rat estrous cycle. Biotechnic and Histochemistry 80, 79-87.
17. Hutchison, W. M., Aitken, P. P. and Wells, B. W. P. (1980a). Chronic Toxoplasma infection and familiarity-novelty discrimination in the mouse. Annals of Tropical Medicine and Parasitology 74, 145-150.
18. Hutchison, W. M., Aitken, P. P. and Wells, B. W. P. (1980b). Chronic Toxoplasma infections and motor performance in the mouse. Annals of Tropical Medicine and Parasitology 74, 505-510.
19. Hutchison, W. M., Bradley, M., Cheyne, W. M., Wells, B. W. P. and Hay, J. (1980c). Behavioural abnormalities in Toxoplasma-infected mice. Annals of Tropical Medicine and Parasitology 74, 337-345.
20. Hutchison, W. M. and Work, K. (1969). Toxoplasma - A versatile parasite. New Scientist 29, 464-466.
21. Jones, B. C., Hou, X. and Cook, M. N. (1996). Effect of exposure to novelty on brain monoamines in C57BL/6 and DBA/2 mice. Physiology and Behavior 59, 361-367.
22. Kabbaj, M. and Akil, H. (2001). Individual differences in novelty-seeking behavior in rats: A c-fos study. Neuroscience 106, 535-545.
23. Kaňková, S., Sulc, J., Nouzová, K., Fajfrlik, K., Frynta, D. and Flegr, J. (2007). Women infected with parasite Toxoplasma have more sons. Naturwissenschaften 94, 122-127.
24. Kodym, P., Blažek, K., Malý, M. and Hrdá, S. (2002). Pathogenesis of experimental toxoplasmosis in mice with strains differing in virulence. Acta Parasitologica 47, 239-248.
25. Kramer, W. (1966). Frontiers of neurological diagnosis in acquired toxoplasmosis. Psychiatria, Neurologia, Neurochirurgia 69, 43-64.
26. Ladee, G. A., Scholten, J. M. and Meyes, F. E. P. (1966). Diagnostic problems in psychiatry with regard to acquired toxoplasmosis. Psychiatria, Neurologia, Neurochirurgia 69, 65-82.
27. Minto, A. and Roberts, F. J. (1959). The psychiatric complications of toxoplasmosis. Lancet 1, 1180-1182.
28. Nieoullon, A. (2002). Dopamine and the regulation of cognition and attention. Progress in Neurobiology 67, 53-83.
29. Novotná, M., Hanušová, J., Klose, J., Preiss, M., Havlíček, J., Roubalová, K. and Flegr, J. (2005). Probable neuroimmunological link between Toxoplasma and cytomegalovirus infections and personality changes in the human host. BMC Infectious Diseases 54, 1-10.
30. Petitto, J. M., McCarthy, D. B., Rinker, C. M., Huang, Z. and Getty, T. (1997). Modulation of behavioral and neurochemical measures of forebrain dopamine function in mice by species-specific interleukin-2. Journal of Neuroimmunology 73, 183-190.
31. Piekarski, G., Zippelius, H. M. and Witting, P. A. (1978). Auswirkungen einer latenten Toxoplasma-Infektion auf das Lernvermogen von weissen Laboratoriumsratten und Mausen. Zeitschrift für Parasitenkunde 57, 1-15.
32. Sawa, A. and Snyder, S. H. (2002). Schizophrenia: diverse approaches to a complex disease. Science 296, 692-695.
33. Skallová, A., Frynta, D., Kodym, P. and Flegr, J. (2006). The role of dopamine in Toxoplasma-induced behavioural alterations in mice: an ethological and ethopharmacological study. Parasitology 133, 525-535.
34. Skallová, A., Novotná, M., Kolbeková, P., Gasová, Z., Veselý, V. and Flegr, J. (2005). Decreased level of novelty seeking in blood donors infected with Toxoplasma. Neuroendocrinology Letters 26, 480-486.
35. Stibbs, H. H. (1985). Changes in brain concentrations of catecholamines and indoleamines in Toxoplasma gondii infected mice. Annals of Tropical Medicine and Parasitology 79, 153-157.
36. Tarr, B. A., Kellaway, L. A., Gibson, A. S. and Russell, V. A. (2004). Voluntary running distance is negatively correlated with striatal dopamine release in untrained rats. Behavioural Brain Research 154, 493-499.
37. Torrey, E. F. and Yolken, R. H. (2003). Toxoplasma gondii and schizophrenia. Emerging Infectious Diseases 9, 1375-1380.
38. Viggiano, D., Vallone, D., Ruocco, L. A. and Sadile, A. G. (2003). Behavioural, pharmacological, morphofunctional molecular studies reveal a hyperfunctioning mesocortical dopamine system in an animal model of attention deficit and hyperactivity disorder. Neuroscience and Biobehavioral Reviews 27, 683-689.
39. Webster, J. P., Brunton, C. F. A. and Macdonald, D. W. (1994). Effect of Toxoplasma gondii upon neophobic behaviour in wild brown rats, Rattus norvegicus. Parasitology 109, 37-43.
40. Witting, P. A. (1979). Learning capacity and memory of normal and Toxoplasma-infected laboratory rats and mice. Zeitschrift für Parasitenkunde 61, 29-51.