Editorial: The role of glucagon in postprandial hyperglycemia - The Jury's still out

Journal of Clinical Endocrinology and Metabolism

Volumn 92, Issue 8, 2007, Pages 2879-2881

  Bollyky, Jennifer ^a   Greenbaum, Carla J ^a  

^a BENAROYA RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; EXENDIN 4; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCAGON RECEPTOR; GLUCOSE; HEMOGLOBIN A1C; HORMONE RECEPTOR BLOCKING AGENT; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; SITAGLIPTIN; SULFONYLUREA; VILDAGLIPTIN;

DIET RESTRICTION; DRUG EFFECT; EDITORIAL; GLUCAGON BLOOD LEVEL; GLUCAGON RELEASE; GLUCOGENESIS; GLYCEMIC CONTROL; GLYCOGENOLYSIS; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN DEFICIENCY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET ALPHA CELL; POSTPRANDIAL STATE; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 34547783357     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2007-1312     Document Type: Editorial

References (20)

1. Lecavalier L, Bolli G, Cryer P, Gerich J 1989 Contributions of gluconeogenesis and glycogenolysis during glucose counterregulation in normal humans. Am J Physiol 256(6 Pt 1):E844-E851
2. Dobbs R, Sakurai H, Sasaki H, Faloona G, Valverde I, Baetens D, Orci L, Unger R 1975 Glucagon: role in the hyperglycemia of diabetes mellitus. Science 187:544-547
3. Clarke WL, Gonder-Frederick LA, Richards FE, Cryer PE 1991 Multifactorial origin of hypoglycemic symptom unawareness in IDDM. Association with defective glucose counterregulation and better glycemic control. Diabetes 40: 680-685
4. Muller WA, Faloona GR, Unger RH 1971 The effect of experimental insulin deficiency on glucagon secretion. J Clin Invest 50:1992-1999
5. Bennett PH, Aronoff SL, Unger RH 1976 Evidence for an insulin-independent α-cell abnormality in human diabetes. Metabolism 25(11 Suppl 1):1527-1529
6. Dunning BE, Gerich JE 2007 The role of α-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications. Endocr Rev 28:253-283
7. Raju B, Cryer PE 2005 Maintenance of the postabsorptive plasma glucose concentration: insulin or insulin plus glucagon? Am J Physiol Endocrinol Metab 289:E181-E186
8. Greenbaum CJ, Havel PJ, Taborsky Jr GJ, Klaff LJ 1991 Intra-islet insulin permits glucose to directly suppress pancreatic A cell function. J Clin Invest 88:767-773
9. Paty BW, Ryan EA, Shapiro AM, Lakey JR, Robertson RP 2002 Intrahepatic islet transplantation in type 1 diabetic patients does not restore hypoglycemic hormonal counterregulation or symptom recognition after insulin independence. Diabetes 51:3428-3434
10. Gelling RW, Du XQ, Dichmann DS, Romer J, Huang H, Cui L, Obici S, Tang B, Holst JJ, Fledelius C, Johansen PB, Rossetti L, Jelicks LA, Serup P, Nishimura E, Charron MJ 2003 Lower blood glucose, hyperglucagonemia, and pancreatic α cell hyperplasia in glucagon receptor knockout mice. Proc Natl Acad Sci USA 100:1438-1443
11. Parker JC, Andrews KM, Allen MR, Stock JL, McNeish JD 2002 Glycemic control in mice with targeted disruption of the glucagon receptor gene. Biochem Biophys Res Commun 290:839-843
12. Furuta M, Zhou A, Webb G, Carroll R, Ravazzola M, Orci L, Steiner DF 2001 Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice. J Biol Chem 276:27197-27202
13. Webb GC, Akbar MS, Zhao C, Swift HH, Steiner DF 2002 Glucagon replacement via micro-osmotic pump corrects hypoglycemia and α-cell hyperplasia in prohormone convertase 2 knockout mice. Diabetes 51:398-405
14. Brand CL, Rolin B, Jorgensen PN, Svendsen I, Kristensen JS, Holst JJ 1994 Immunoneutralization of endogenous glucagon with monoclonal glucagon antibody normalizes hyperglycaemia in moderately streptozotocin-diabetic rats. Diabetologia 37:985-993
15. Vieira E, Salehi A, Gylfe E 2007 Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic α cells. Diabetologia 50:370-379
16. Pörksen S, Nielsen LB, Kaas A, Kocova M, Chiarelli F, Ørskov C, Holst JJ, Ploug KB, Hougaard P, Hansen L, Mortensen HB, and the Hvidøre Study Group on Childhood Diabetes 2007 Meal-stimulated glucagon release is associated with postprandial blood glucose level and does not interfere with glycemic control in children and adolescents with new-onset type 1 diabetes. J Clin Endocrinol Metab 92:2910-2916
17. Greenbaum CJ, Prigeon RL, D'Alessio DA 2002 Impaired β-cell function, incretin effect, and glucagon suppression in patients with type 1 diabetes who have normal fasting glucose. Diabetes 51:951-957
18. Drucker DJ 2007 The role of gut hormones in glucose homeostasis. J Clin Invest 117:24-32
19. Unson CG, Andreu D, Gurzenda EM, Merrifield RB 1987 Synthetic peptide antagonists of glucagon. Proc Natl Acad Sci USA 84:4083-4087
20. Nathan DM 2007 Finding new treatments for diabetes - how many, how fast . . . how good? N Engl J Med 356:437-440