Haploinsufficiency of the cdc2l gene contributes to skin cancer development in mice

Carcinogenesis

Volumn 28, Issue 9, 2007, Pages 2028-2035

  Chandramouli, Anupama ^a   Shi, Jiaqi ^a   Feng, Yongmei ^a   Holubec, Hana ^a   M shanas, Renée ^a   Bhattacharyya, Achyut K ^a   Zheng, Wenxin ^a   Nelson, Mark A ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 21; DIMETHYLBENZ[A]ANTHRACENE; KI 67 ANTIGEN; PHORBOL 13 ACETATE 12 MYRISTATE; RAS PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CODON; CONTROLLED STUDY; GENE MUTATION; GENE TECHNOLOGY; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PAPILLOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN FUNCTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SKIN CANCER; SKIN CARCINOGENESIS; TUMOR VOLUME; WILD TYPE;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; CARCINOGENS; CODON; CROSSES, GENETIC; DNA HELICASES; FEMALE; GENES, RAS; MALE; MICE; MICE, INBRED C57BL; PAPILLOMA; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SKIN NEOPLASMS; TETRADECANOYLPHORBOL ACETATE;

EID: 34547782947     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgm066     Document Type: Article

References (36)

1. Loyer,P. et al. (1998) The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinase in vivo. J. Cell Sci., 111, 495-506.
2. Trembley,J.H. et al. (2002) PITSLRE p110 protein kinases associate with transcription complexes and affect their activity. J. Biol. Chem., 277, 2589-2596.
3. Dickinson,L.A. et al. (2002) Cyclin L is an RS domain protein involved in pre-mRNA splicing. J. Biol. Chem., 277, 25465-25473.
4. Hu,D. et al. (2003) CDK11 complexes promote pre-mRNA splicing. J. Biol. Chem., 278, 8623-8629.
5. Mayeda,A. et al. (1999) Purification and characterization of human RNPS1: A general activator of pre-mRNA splicing. EMBO J., 18 4560-4570.
6. Trembley,J.H. et al. (2003) Casein kinase 2 interacts with cyclin-dependent kinase 11 (CDK11) in vivo and phosphorylates both the RNA polymerase II carboxyl-terminal domain and CDK11 in vitro. J. Biol. Chem., 278, 2265-2270.
7. Petretti,C. et al. (2006) The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation. EMBO Rep., 7, 418-424.
8. Lahti,J.M. et al. (1995) PITSLRE protein kinase activity is associated with apoptosis. Mol. Cell. Biol., 15, 1-11.
9. Ariza,M.E. et al. (1999) Fas-induced apoptosis in human malignant melanoma cell lines is associated with the activation of the p34(cdc2)-related PITSLRE protein kinases. J. Biol. Chem., 274 28505-28513.
10. Beyaert,R. et al. (1997) Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor. J. Biol. Chem., 272, 11694-11697.
11. Tang,D. et al. (1998) Phosphorylation of PITSLRE p110 isoforms accompanies their processing by caspases during Fas-mediated cell death. J. Biol. Chem., 273, 16601-16607.
12. Shi,J. et al. (2003) The p34cdc2-related cyclin-dependent kinase 11 interacts with the p47 subunit of eukaryotic initiation factor 3 during apoptosis. J. Biol. Chem., 278, 5062-5071.
13. Perlman,E.J. et al. (1996) Deletion of 1p36 in childhood endodermal sinus tumors by two-color fluorescence in situ hybridization: a pediatric oncology group study. Genes Chromosomes Cancer, 16 15-20.
14. Lahti,J.M. et al. (1994) Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma. Nat. Genet., 7, 370-375.
15. Dave,B.J. et al. (1999) Deletion of cell division cycle 2-like 1 gene locus on 1p36 in non-Hodgkin lymphoma. Cancer Genet. Cytogenet. 108, 120-126.
16. Chin,L. et al. (2006) Malignant melanoma: Genetics and therapeutics in the genomic era. Genes Dev., 20, 2149-2182.
17. Wang,Q. et al. (2006) Integrative genomics identifies distinct molecular classes of neuroblastoma and shows that multiple genes are targeted by regional alterations in DNA copy number. Cancer Res., 66, 6050-6062.
18. Barrett,T. et al. (2005) NCBI GEO: Mining millions of expression profiles - database and tools. Nucleic Acids Res., 33, D562-D566.
19. Nelson,M.A. et al. (1999) Abnormalities in the p34cdc2-related PITSLRE protein kinase gene complex (CDC2L) on chromosome band 1p36 in melanoma. Cancer Genet. Cytogenet., 108, 91-99.
20. Li,T. et al. (2004) Failure to proliferate and mitotic arrest of CDK11(p110/p58)-null mutant mice at the blastocyst stage of embryonic cell development. Mol. Cell. Biol., 24, 3188-3197.
21. You,M.J. et al. (2002) Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice. Proc. Natl Acad. Sci. USA, 99, 1455-1460.
22. Zhang,Z. et al. (2005) Induction of invasive mouse skin carcinomas in transgenic mice with mutations in both H-ras and p53. Mol. Cancer Res., 3, 563-574.
23. Stanford,W.L. et al. (2001) Gene-trap mutagenesis: Past, present and beyond. Nat. Rev. Genet., 2, 756-768.
24. Stryke,D. et al. (2003) BayGenomics: A resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res., 31 278-281.
25. Skarnes,W.C. (2005) Two ways to trap a gene in mice. Proc. Natl Acad. Sci. USA, 102, 13001-13002.
26. Steel,G.G. (1993) The heyday of cell population kinetics: Insights from the 1960s and 1970s. Semin. Radiat. Oncol., 3, 78-83.
27. Yerushalmi,H.F. et al. (2006) Role of polyamines in arginine-dependent colon carcinogenesis in Apc(Min) (/+) mice. Mol. Carcinog., 45, 764-773.
28. Nagase,H. et al. (2003) Allele-specific Hras mutations and genetic alterations at tumor susceptibility loci in skin carcinomas from interspecific hybrid mice. Cancer Res., 63, 4849-4853.
29. Balmain,A. et al. (1984) Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas. Nature 307, 658-660.
30. Quintanilla,M. et al. (1986) Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature, 322, 78-80.
31. Tang,M.S. et al. (2000) Both (+/-)syn- and (+/-)anti-7,12-dimethylbenz [a]anthracene-3,4-diol-1,2-epoxides initiate tumors in mouse skin that possess -CAA- to -CTA- mutations at Codon 61 of c-H-ras. Cancer Res., 60, 5688-5695.
32. Formisano,P. et al. (2005) Raised expression of the antiapoptotic protein ped/pea-15 increases susceptibility to chemically induced skin tumor development. Oncogene, 24, 7012-7021.
33. Hsieh,Y.H. et al. (2006) Papilloma development is delayed in osteopontin-null mice: Implicating an antiapoptosis role for osteopontin. Cancer Res., 66, 7119-7127.
34. Nicol,C.J. et al. (2004) PPARgamma influences susceptibility to DMBA-induced mammary, ovarian and skin carcinogenesis. Carcinogenesis 25, 1747-1755.
35. Suzuki,J.S. et al. (2003) Metallothionein deficiency enhances skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate in metallothionein-null mice. Carcinogenesis, 24, 1123-1132.
36. Francone,V.P. et al. (2005) Diversification of CDKl1 transcripts during chicken testis development and regression. Mol. Reprod. Dev. 72, 273-280.