메뉴 건너뛰기




Volumn 2, Issue 3, 2007, Pages 193-201

Treatment of pediatric acute lymphoblastic leukemia: Progress achieved and challenges remaining

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE; ASPARAGINASE; ASPARAGINASE MACROGOL; CYCLOPHOSPHAMIDE; CYTARABINE; DAUNORUBICIN; DEXAMETHASONE; DOXORUBICIN; ETOPOSIDE; FOLINIC ACID; HYDROCORTISONE; MERCAPTOPURINE; METHOTREXATE; PREDNISONE; TIOGUANINE; VINCRISTINE;

EID: 34547780130     PISSN: 15588211     EISSN: 1558822X     Source Type: Journal    
DOI: 10.1007/s11899-007-0026-y     Document Type: Review
Times cited : (5)

References (87)
  • 1
    • 0034525989 scopus 로고    scopus 로고
    • Children's Cancer Group trials in childhood acute lymphoblastic leukemia: 1983-1995
    • Gaynon PS, Trigg ME, Heerema NA, et al.: Children's Cancer Group trials in childhood acute lymphoblastic leukemia: 1983-1995. Leukemia 2000, 14:2223-2233.
    • (2000) Leukemia , vol.14 , pp. 2223-2233
    • Gaynon, P.S.1    Trigg, M.E.2    Heerema, N.A.3
  • 2
    • 17744383161 scopus 로고    scopus 로고
    • Long-term results of Total Therapy studies 11, 12 and 13A for childhood acute lymphoblastic leukemia at St Jude Children's Research Hospital
    • Pui CH, Boyett JM, Rivera GK, et al.: Long-term results of Total Therapy studies 11, 12 and 13A for childhood acute lymphoblastic leukemia at St Jude Children's Research Hospital. Leukemia 2000, 14:2286-2294.
    • (2000) Leukemia , vol.14 , pp. 2286-2294
    • Pui, C.H.1    Boyett, J.M.2    Rivera, G.K.3
  • 3
    • 0034517924 scopus 로고    scopus 로고
    • Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995. Berlin-Frankfurt-Münster
    • Schrappe M, Reiter A, Zimmermann M, et al.: Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995. Berlin-Frankfurt-Münster. Leukemia 2000, 14:2205-2222.
    • (2000) Leukemia , vol.14 , pp. 2205-2222
    • Schrappe, M.1    Reiter, A.2    Zimmermann, M.3
  • 4
    • 17744380400 scopus 로고    scopus 로고
    • Results of Dana-Farber Cancer Institute Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia
    • Silverman LB, Declerck L, Gelber RD, et al.: Results of Dana-Farber Cancer Institute Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia (1981-1995). Leukemia 2000, 14:2247-2256.
    • (2000) Leukemia , vol.14 , pp. 2247-2256
    • Silverman, L.B.1    Declerck, L.2    Gelber, R.D.3
  • 6
    • 0242361142 scopus 로고    scopus 로고
    • Long-term follow-up of relapsed childhood acute lymphoblastic leukaemia
    • Chessells JM, Veys P, Kempski H, et al.: Long-term follow-up of relapsed childhood acute lymphoblastic leukaemia. Br J Haematol 2003, 123:396-405.
    • (2003) Br J Haematol , vol.123 , pp. 396-405
    • Chessells, J.M.1    Veys, P.2    Kempski, H.3
  • 7
    • 37649005377 scopus 로고
    • Factors influencing survival after relapse from childhood ALL: A Children's Oncology Group study [abstract]
    • Abstract
    • Nguyen K, Cheng SC, Raetz E, et al.: Factors influencing survival after relapse from childhood ALL: a Children's Oncology Group study [abstract]. Blood (ASH Annual Meeting Abstracts) 2006, 108:Abstract 1855.
    • (1855) Blood (ASH Annual Meeting Abstracts) , vol.108
    • Nguyen, K.1    Cheng, S.C.2    Raetz, E.3
  • 8
    • 33746012670 scopus 로고    scopus 로고
    • • Barredo JC, Devidas M, Lauer SJ, et al.: Isolated CNS relapse of acute lymphoblastic leukemia treated with intensive systemic chemotherapy and delayed CNS radiation: a Pediatric Oncology Group study. J Clin Oncol 2006, 24:3142-3149. Barredo et al. obtain substantially good outcomes for patients with early or later isolated CNS relapse.
    • • Barredo JC, Devidas M, Lauer SJ, et al.: Isolated CNS relapse of acute lymphoblastic leukemia treated with intensive systemic chemotherapy and delayed CNS radiation: a Pediatric Oncology Group study. J Clin Oncol 2006, 24:3142-3149. Barredo et al. obtain substantially good outcomes for patients with early or later isolated CNS relapse.
  • 9
    • 33846892770 scopus 로고    scopus 로고
    • • Schultz KR, Pullen DJ, Sather HN, et al.: Risk- and response-based classification of childhood B-precursor acute lymphoblastic leukemia: a combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children's Cancer Group (CCG). Blood 2007, 109:926-935. Schultz et al. explore an enormous pre-MRD database and examine various potential prognostic factors.
    • • Schultz KR, Pullen DJ, Sather HN, et al.: Risk- and response-based classification of childhood B-precursor acute lymphoblastic leukemia: a combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children's Cancer Group (CCG). Blood 2007, 109:926-935. Schultz et al. explore an enormous pre-MRD database and examine various potential prognostic factors.
  • 10
    • 0032572924 scopus 로고    scopus 로고
    • Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia. European Organization for Research and Treatment of Cancer - Childhood Leukemia Cooperative Group
    • Cave H, van der Werff ten Bosch J, Suciu S, et al.: Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia. European Organization for Research and Treatment of Cancer - Childhood Leukemia Cooperative Group. N Engl J Med 1998, 339:591-598.
    • (1998) N Engl J Med , vol.339 , pp. 591-598
    • Cave, H.1    van der Werff ten Bosch, J.2    Suciu, S.3
  • 11
    • 0032576355 scopus 로고    scopus 로고
    • Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood
    • van Dongen JJ, Seriu T, Panzer-Grumayer ER, et al.: Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood. Lancet 1998, 352:1731-1738.
    • (1998) Lancet , vol.352 , pp. 1731-1738
    • van Dongen, J.J.1    Seriu, T.2    Panzer-Grumayer, E.R.3
  • 12
    • 7344254683 scopus 로고    scopus 로고
    • Critical study of prognostic factors in childhood acute lymphoblastic leukaemia: Differences in outcome are poorly explained by the most significant prognostic variables. Fralle group. French Acute Lymphoblastic Leukaemia study group
    • Donadieu J, Auclerc MF, Baruchel A, et al.: Critical study of prognostic factors in childhood acute lymphoblastic leukaemia: differences in outcome are poorly explained by the most significant prognostic variables. Fralle group. French Acute Lymphoblastic Leukaemia study group. Br J Haematol 1998, 102:729-739.
    • (1998) Br J Haematol , vol.102 , pp. 729-739
    • Donadieu, J.1    Auclerc, M.F.2    Baruchel, A.3
  • 13
    • 0018359420 scopus 로고
    • The ninth annual David Karnofsky Lecture. Treatment of acute lymphocytic leukemia
    • Pinkel D: The ninth annual David Karnofsky Lecture. Treatment of acute lymphocytic leukemia. Cancer 1979, 43:1128-1137.
    • (1979) Cancer , vol.43 , pp. 1128-1137
    • Pinkel, D.1
  • 14
    • 0018610437 scopus 로고
    • Childhood leukemia as a model for cancer research: The Richard and Hilda Rosenthal Foundation Award Lecture
    • Simone J: Childhood leukemia as a model for cancer research: the Richard and Hilda Rosenthal Foundation Award Lecture. Cancer 1979, 39:4301-4307.
    • (1979) Cancer , vol.39 , pp. 4301-4307
    • Simone, J.1
  • 15
    • 0023135866 scopus 로고
    • Differences in cerebrospinal fluid penetration of corticosteroids: Possible relationship to the prevention of meningeal leukemia
    • Balis FM, Lester CM, Chrousos GP, et al.: Differences in cerebrospinal fluid penetration of corticosteroids: possible relationship to the prevention of meningeal leukemia. J Clin Oncol 1987, 5:202-207.
    • (1987) J Clin Oncol , vol.5 , pp. 202-207
    • Balis, F.M.1    Lester, C.M.2    Chrousos, G.P.3
  • 16
    • 0038264383 scopus 로고    scopus 로고
    • Dexamethasone versus prednisone and daily oral versus weekly intravenous mercaptopurine for patients with standard-risk acute lymphoblastic leukemia: A report from the Children's Cancer Group
    • Bostrom BC, Sensel MR, Sather HN, et al.: Dexamethasone versus prednisone and daily oral versus weekly intravenous mercaptopurine for patients with standard-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group. Blood 2003, 101:3809-3817.
    • (2003) Blood , vol.101 , pp. 3809-3817
    • Bostrom, B.C.1    Sensel, M.R.2    Sather, H.N.3
  • 17
    • 9044226139 scopus 로고    scopus 로고
    • Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia
    • Smith M, Arthur D, Camitta B, et al.: Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia. J Clin Oncol 1996, 14:18-24.
    • (1996) J Clin Oncol , vol.14 , pp. 18-24
    • Smith, M.1    Arthur, D.2    Camitta, B.3
  • 18
    • 0034655211 scopus 로고    scopus 로고
    • Substituting dexamethasone for prednisone complicates remission induction in children with acute lymphoblastic leukemia
    • Hurwitz CA, Silverman LB, Schorin MA, et al.: Substituting dexamethasone for prednisone complicates remission induction in children with acute lymphoblastic leukemia. Cancer 2000, 88:1964-1969.
    • (2000) Cancer , vol.88 , pp. 1964-1969
    • Hurwitz, C.A.1    Silverman, L.B.2    Schorin, M.A.3
  • 19
    • 21344451860 scopus 로고    scopus 로고
    • • Mitchell CD, Richards SM, Kinsey SE, et al.: Benefit of dexamethasone compared with prednisolone for childhood acute lymphoblastic leukaemia: results of the UK Medical Research Council ALL97 randomized trial. Br J Haematol 2005, 129:734-745. Mitchell et al. confirm the findings of Bostrom et al. [16] and extend the observation to higher-risk ALL and a four-drug, anthracycline-containing induction.
    • • Mitchell CD, Richards SM, Kinsey SE, et al.: Benefit of dexamethasone compared with prednisolone for childhood acute lymphoblastic leukaemia: results of the UK Medical Research Council ALL97 randomized trial. Br J Haematol 2005, 129:734-745. Mitchell et al. confirm the findings of Bostrom et al. [16] and extend the observation to higher-risk ALL and a four-drug, anthracycline-containing induction.
  • 20
    • 20244373046 scopus 로고    scopus 로고
    • Early response to induction is predictive of survival in childhood Philadelphia chromosome positive acute lymphoblastic leukaemia: Results of the Medical Research Council ALL 97 trial
    • Roy A, Bradburn M, Moorman AV, et al.: Early response to induction is predictive of survival in childhood Philadelphia chromosome positive acute lymphoblastic leukaemia: results of the Medical Research Council ALL 97 trial. Br J Haematol 2005, 129:35-44.
    • (2005) Br J Haematol , vol.129 , pp. 35-44
    • Roy, A.1    Bradburn, M.2    Moorman, A.V.3
  • 21
    • 0025895829 scopus 로고
    • Results of Medical Research Council Childhood Leukaemia Trial UKALL VIII (report to the Medical Research Council on behalf of the Working Party on Leukaemia in Childhood)
    • Eden OB, Lilleyman JS, Richards S, et al.: Results of Medical Research Council Childhood Leukaemia Trial UKALL VIII (report to the Medical Research Council on behalf of the Working Party on Leukaemia in Childhood). Br J Haematol 1991, 78:187-196.
    • (1991) Br J Haematol , vol.78 , pp. 187-196
    • Eden, O.B.1    Lilleyman, J.S.2    Richards, S.3
  • 22
    • 10144246581 scopus 로고    scopus 로고
    • Duration and intensity of maintenance chemotherapy in acute lymphoblastic leukaemia: Overview of 42 trials involving 12 000 randomised children. Childhood ALL Collaborative Group
    • Duration and intensity of maintenance chemotherapy in acute lymphoblastic leukaemia: overview of 42 trials involving 12 000 randomised children. Childhood ALL Collaborative Group. Lancet 1996, 347:1783-1788.
    • (1996) Lancet , vol.347 , pp. 1783-1788
  • 23
    • 0025642988 scopus 로고
    • Non-randomised study comparing toxicity of Escherichia coli and Erwinia asparaginase in children with leukaemia
    • Eden OB, Shaw MP, Lilleyman JS, et al.: Non-randomised study comparing toxicity of Escherichia coli and Erwinia asparaginase in children with leukaemia. Med Pediatr Oncol 1990, 18:497-502.
    • (1990) Med Pediatr Oncol , vol.18 , pp. 497-502
    • Eden, O.B.1    Shaw, M.P.2    Lilleyman, J.S.3
  • 24
    • 0037089437 scopus 로고    scopus 로고
    • Comparison of Escherichia coli-asparaginase with Erwinia-asparaginase in the treatment of childhood lymphoid malignancies: Results of a randomized European Organisation for Research and Treatment of Cancer-Children's Leukemia Group phase 3 trial
    • Duval M, Suciu S, Ferster A, et al.: Comparison of Escherichia coli-asparaginase with Erwinia-asparaginase in the treatment of childhood lymphoid malignancies: results of a randomized European Organisation for Research and Treatment of Cancer-Children's Leukemia Group phase 3 trial. Blood 2002, 99:2734-2739.
    • (2002) Blood , vol.99 , pp. 2734-2739
    • Duval, M.1    Suciu, S.2    Ferster, A.3
  • 25
    • 33846882147 scopus 로고    scopus 로고
    • • Moghrabi A, Levy DE, Asselin B, et al.: Results of the Dana-Farber Cancer Institute ALL Consortium Protocol 95-01 for children with acute lymphoblastic leukemia. Blood 2007, 109:896-904. Moghrabi et al. confirm the findings of Duval et al. [24] with a different asparaginase schedule.
    • • Moghrabi A, Levy DE, Asselin B, et al.: Results of the Dana-Farber Cancer Institute ALL Consortium Protocol 95-01 for children with acute lymphoblastic leukemia. Blood 2007, 109:896-904. Moghrabi et al. confirm the findings of Duval et al. [24] with a different asparaginase schedule.
  • 26
    • 2942677283 scopus 로고    scopus 로고
    • Asparaginase pharmacodynamics differ by formulation among children with newly diagnosed acute lymphoblastic leukemia
    • Hak LJ, Relling MV, Cheng C, et al.: Asparaginase pharmacodynamics differ by formulation among children with newly diagnosed acute lymphoblastic leukemia. Leukemia 2004, 18:1072-1077.
    • (2004) Leukemia , vol.18 , pp. 1072-1077
    • Hak, L.J.1    Relling, M.V.2    Cheng, C.3
  • 27
    • 0019522545 scopus 로고
    • Presymptomatic central nervous system therapy in previously untreated childhood acute lymphoblastic leukaemia: Comparison of 1800 rad and 2400 rad. A report for Children's Cancer Study Group
    • Nesbit ME, Robison LL, Littman PS, et al.: Presymptomatic central nervous system therapy in previously untreated childhood acute lymphoblastic leukaemia: comparison of 1800 rad and 2400 rad. A report for Children's Cancer Study Group. Lancet 1981, 1(8218):461-466.
    • (1981) Lancet , vol.1 , Issue.8218 , pp. 461-466
    • Nesbit, M.E.1    Robison, L.L.2    Littman, P.S.3
  • 28
    • 3042581215 scopus 로고    scopus 로고
    • Evolution of BFM trials for childhood ALL
    • Schrappe M: Evolution of BFM trials for childhood ALL. Ann Hematol 2004, 83(suppl 1):S121-S123.
    • (2004) Ann Hematol , vol.83 , Issue.SUPPL. 1
    • Schrappe, M.1
  • 29
    • 0018818464 scopus 로고
    • Comparison of three methods of central-nervous-system prophylaxis in childhood acute lymphoblastic leukemia
    • Green DM, Freeman AI, Sather HN, et al.: Comparison of three methods of central-nervous-system prophylaxis in childhood acute lymphoblastic leukemia. Lancet 1980, 1(8183):1398-1402.
    • (1980) Lancet , vol.1 , Issue.8183 , pp. 1398-1402
    • Green, D.M.1    Freeman, A.I.2    Sather, H.N.3
  • 30
    • 0021088257 scopus 로고
    • Reduction in central nervous system leukemia with a pharmacokinetically derived intrathecal methotrexate dosage regimen
    • Bleyer WA, Coccia PF, Sather HN, et al.: Reduction in central nervous system leukemia with a pharmacokinetically derived intrathecal methotrexate dosage regimen. J Clin Oncol 1983, 1:317-325.
    • (1983) J Clin Oncol , vol.1 , pp. 317-325
    • Bleyer, W.A.1    Coccia, P.F.2    Sather, H.N.3
  • 31
    • 33747199596 scopus 로고    scopus 로고
    • • Matloub Y, Lindemulder S, Gaynon PS, et al.: Intrathecal triple therapy decreases central nervous system relapse but fails to improve event-free survival when compared with intrathecal methotrexate: results of the Children's Cancer Group (CCG) 1952 study for standard-risk acute lymphoblastic leukemia, reported by the Children's Oncology Group. Blood 2006, 108:1165-1173. Matloub et al. find that intrathecal triple therapy decreases CNS relapse as predicted, but patients suffer excess marrow and testes relapse, which results in similar EFS but inferior overall survival.
    • • Matloub Y, Lindemulder S, Gaynon PS, et al.: Intrathecal triple therapy decreases central nervous system relapse but fails to improve event-free survival when compared with intrathecal methotrexate: results of the Children's Cancer Group (CCG) 1952 study for standard-risk acute lymphoblastic leukemia, reported by the Children's Oncology Group. Blood 2006, 108:1165-1173. Matloub et al. find that intrathecal triple therapy decreases CNS relapse as predicted, but patients suffer excess marrow and testes relapse, which results in similar EFS but inferior overall survival.
  • 32
    • 0036739780 scopus 로고    scopus 로고
    • Schedule-dependent synergy and antagonism between methotrexate and cytarabine against human cell lines in vitro
    • Akutsu M, Furukawa Y, Tsunoda S, et al.: Schedule-dependent synergy and antagonism between methotrexate and cytarabine against human cell lines in vitro. Leukemia 2002, 16:1808-1817.
    • (2002) Leukemia , vol.16 , pp. 1808-1817
    • Akutsu, M.1    Furukawa, Y.2    Tsunoda, S.3
  • 33
    • 0027973369 scopus 로고
    • The cytotoxicity of thioguanine vs mercaptopurine in acute lymphoblastic leukemia
    • Adamson PC, Poplack DG, Balis FM: The cytotoxicity of thioguanine vs mercaptopurine in acute lymphoblastic leukemia. Leuk Res 1994, 18:805-810.
    • (1994) Leuk Res , vol.18 , pp. 805-810
    • Adamson, P.C.1    Poplack, D.G.2    Balis, F.M.3
  • 34
    • 3042650547 scopus 로고    scopus 로고
    • Comparison of mercaptopurine with thioguanine and IT methotrexate with IT "triples" in children with standard risk (SR) ALL: Results of CCG-1952 [abstract]
    • Stork LC, Sather H, Hutchinson RJ, et al.: Comparison of mercaptopurine with thioguanine and IT methotrexate with IT "triples" in children with standard risk (SR) ALL: results of CCG-1952 [abstract]. Blood 2002, 100:36a.
    • (2002) Blood , vol.100
    • Stork, L.C.1    Sather, H.2    Hutchinson, R.J.3
  • 35
    • 33749515604 scopus 로고    scopus 로고
    • Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: A randomised trial
    • Vora A, Mitchell CD, Lennard L, et al.: Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial. Lancet 2006, 368:1339-1348.
    • (2006) Lancet , vol.368 , pp. 1339-1348
    • Vora, A.1    Mitchell, C.D.2    Lennard, L.3
  • 36
    • 0012486360 scopus 로고    scopus 로고
    • Oral 6-thioguanine causes relatively mild and reversible hepatic veno-occlusive disease [abstract]
    • Abstract 672
    • Stork L, Erdmann G, Adamson P, et al.: Oral 6-thioguanine causes relatively mild and reversible hepatic veno-occlusive disease [abstract]. J Pediatr Hematol Oncol 1998, 20:400 (Abstract 672).
    • (1998) J Pediatr Hematol Oncol , vol.20 , pp. 400
    • Stork, L.1    Erdmann, G.2    Adamson, P.3
  • 37
    • 0141923920 scopus 로고    scopus 로고
    • Thioguanine offers no advantage over mercaptopurine in maintenance treatment of childhood ALL: Results of the randomized trial COALL-92
    • Harms DO, Gobel U, Spaar HJ, et al.: Thioguanine offers no advantage over mercaptopurine in maintenance treatment of childhood ALL: results of the randomized trial COALL-92. Blood 2003, 102:2736-2740.
    • (2003) Blood , vol.102 , pp. 2736-2740
    • Harms, D.O.1    Gobel, U.2    Spaar, H.J.3
  • 38
    • 0019763549 scopus 로고
    • Asparaginase-methotrexate in combination chemotherapy: Schedule-dependent differential effects on normal versus neoplastic cells
    • Capizzi RL: Asparaginase-methotrexate in combination chemotherapy: schedule-dependent differential effects on normal versus neoplastic cells. Cancer Treat Rep 1981, 65(suppl 4):115-121.
    • (1981) Cancer Treat Rep , vol.65 , Issue.SUPPL. 4 , pp. 115-121
    • Capizzi, R.L.1
  • 39
    • 27744459610 scopus 로고    scopus 로고
    • Early treatment intensification improves outcome in children with acute lymphoblastic leukemia (ALL) and unfavorable features who show a rapid early response (RER) to induction chemotherapy: A report of CCG-1961 [abstract]
    • Seibel NL, Steinherz PG, Sather H, et al.: Early treatment intensification improves outcome in children with acute lymphoblastic leukemia (ALL) and unfavorable features who show a rapid early response (RER) to induction chemotherapy: a report of CCG-1961 [abstract]. Blood 2003, 102:224a.
    • (2003) Blood , vol.102
    • Seibel, N.L.1    Steinherz, P.G.2    Sather, H.3
  • 40
    • 33750334632 scopus 로고    scopus 로고
    • High leucovorin doses during high-dose methotrexate treatment may reduce the cure rate in childhood acute lymphoblastic leukemia
    • Skarby TV, Anderson H, Heldrup J, et al.: High leucovorin doses during high-dose methotrexate treatment may reduce the cure rate in childhood acute lymphoblastic leukemia. Leukemia 2006, 20:1955-1962.
    • (2006) Leukemia , vol.20 , pp. 1955-1962
    • Skarby, T.V.1    Anderson, H.2    Heldrup, J.3
  • 41
    • 33645454373 scopus 로고    scopus 로고
    • •• Sterba J, Dusek L, Demlova R, et al.: Pretreatment plasma folate modulates the pharmacodynamic effect of high-dose methotrexate in children with acute lymphoblastic leukemia and non-Hodgkin lymphoma: folate overrescue concept revisited. Clin Chem 2006, 52:692-700. Sterba et al. explore the pharmacodynamics of intermediate-dose methotrexate and leucovorin rescue and provide reasons for the repeated failure of this intervention in numerous randomized trials.
    • •• Sterba J, Dusek L, Demlova R, et al.: Pretreatment plasma folate modulates the pharmacodynamic effect of high-dose methotrexate in children with acute lymphoblastic leukemia and non-Hodgkin lymphoma: "folate overrescue" concept revisited. Clin Chem 2006, 52:692-700. Sterba et al. explore the pharmacodynamics of intermediate-dose methotrexate and leucovorin rescue and provide reasons for the repeated failure of this intervention in numerous randomized trials.
  • 42
    • 0019988804 scopus 로고
    • Which is the best methotrexate schedule for maintenance therapy of childhood ALL? A randomized study] [Article in German]
    • Wehinger H, Gutjahr P, Hofweber K, et al.: [Which is the best methotrexate schedule for maintenance therapy of childhood ALL? A randomized study] [Article in German]. Klin Padiatr 1982, 194:214-218.
    • (1982) Klin Padiatr , vol.194 , pp. 214-218
    • Wehinger, H.1    Gutjahr, P.2    Hofweber, K.3
  • 43
    • 0023872918 scopus 로고
    • Comparison of intermittent or continuous methotrexate plus 6-mercaptopurine in regimens for standard-risk acute lymphoblastic leukemia in childhood (JCCLSG-S811). The Japanese Children's Cancer and Leukemia Study Group
    • Koizumi S, Fujimoto T, Takeda T, et al.: Comparison of intermittent or continuous methotrexate plus 6-mercaptopurine in regimens for standard-risk acute lymphoblastic leukemia in childhood (JCCLSG-S811). The Japanese Children's Cancer and Leukemia Study Group. Cancer 1988, 61:1292-1300.
    • (1988) Cancer , vol.61 , pp. 1292-1300
    • Koizumi, S.1    Fujimoto, T.2    Takeda, T.3
  • 44
    • 33644840600 scopus 로고    scopus 로고
    • Acute lymphoblastic leukaemia: A model for the pharmacogenomics of cancer therapy
    • Cheok MH, Evans WE: Acute lymphoblastic leukaemia: a model for the pharmacogenomics of cancer therapy. Nat Rev Cancer 2006, 6:117-129.
    • (2006) Nat Rev Cancer , vol.6 , pp. 117-129
    • Cheok, M.H.1    Evans, W.E.2
  • 45
    • 0033486029 scopus 로고    scopus 로고
    • Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus
    • Relling MV, Hancock ML, Rivera GK, et al.: Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus. J Natl Cancer Inst 1999, 91:2001-2008.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 2001-2008
    • Relling, M.V.1    Hancock, M.L.2    Rivera, G.K.3
  • 46
    • 0033645405 scopus 로고    scopus 로고
    • Polymorphisms within glutathione S-transferase genes and initial response to glucocorticoids in childhood acute lymphoblastic leukaemia
    • Anderer G, Schrappe M, Brechlin AM, et al.: Polymorphisms within glutathione S-transferase genes and initial response to glucocorticoids in childhood acute lymphoblastic leukaemia. Pharmacogenetics 2000, 10:715-726.
    • (2000) Pharmacogenetics , vol.10 , pp. 715-726
    • Anderer, G.1    Schrappe, M.2    Brechlin, A.M.3
  • 47
    • 22144446041 scopus 로고    scopus 로고
    • Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia
    • de Jonge R, Hooijberg JH, van Zelst BD, et al.: Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia. Blood 2005, 106:717-720.
    • (2005) Blood , vol.106 , pp. 717-720
    • de Jonge, R.1    Hooijberg, J.H.2    van Zelst, B.D.3
  • 48
    • 0032545976 scopus 로고    scopus 로고
    • Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia
    • Evans WE, Relling MV, Rodman JH, et al.: Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia. N Engl J Med 1998, 338:499-505.
    • (1998) N Engl J Med , vol.338 , pp. 499-505
    • Evans, W.E.1    Relling, M.V.2    Rodman, J.H.3
  • 49
    • 0038576296 scopus 로고    scopus 로고
    • Intensification of mercaptopurine/methotrexate maintenance chemotherapy may increase the risk of relapse for some children with acute lymphoblastic leukemia
    • Schmiegelow K, Bjork O, Glomstein A, et al.: Intensification of mercaptopurine/methotrexate maintenance chemotherapy may increase the risk of relapse for some children with acute lymphoblastic leukemia. J Clin Oncol 2003, 21:1332-1339.
    • (2003) J Clin Oncol , vol.21 , pp. 1332-1339
    • Schmiegelow, K.1    Bjork, O.2    Glomstein, A.3
  • 50
    • 0020630939 scopus 로고
    • Prolonged second remissions in childhood acute lymphocytic leukemia: A report from the Childrens Cancer Study Group
    • Baum E, Nachman J, Ramsay N, et al.: Prolonged second remissions in childhood acute lymphocytic leukemia: a report from the Childrens Cancer Study Group. Med Pediatr Oncol 1983, 11:1-7.
    • (1983) Med Pediatr Oncol , vol.11 , pp. 1-7
    • Baum, E.1    Nachman, J.2    Ramsay, N.3
  • 51
    • 0034284267 scopus 로고    scopus 로고
    • Weekly polyethylene glycol conjugated L-asparaginase compared with biweekly dosing produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: A Pediatric Oncology Group Study
    • Abshire TC, Pollock BH, Billett AL, et al.: Weekly polyethylene glycol conjugated L-asparaginase compared with biweekly dosing produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: a Pediatric Oncology Group Study. Blood 2000, 96:1709-1715.
    • (2000) Blood , vol.96 , pp. 1709-1715
    • Abshire, T.C.1    Pollock, B.H.2    Billett, A.L.3
  • 52
    • 0028234047 scopus 로고
    • PCR assessment of bone marrow status in "isolated" extramedullary relapse of childhood B-precursor acute lymphoblastic leukaemia
    • Goulden N, Langlands K, Steward C, et al.: PCR assessment of bone marrow status in "isolated" extramedullary relapse of childhood B-precursor acute lymphoblastic leukaemia. Br J Haematol 1994, 87:282-285.
    • (1994) Br J Haematol , vol.87 , pp. 282-285
    • Goulden, N.1    Langlands, K.2    Steward, C.3
  • 53
    • 0028198879 scopus 로고
    • Molecular evidence for minimal residual bone marrow disease in children with "isolated" extra-medullary relapse of T-cell acute lymphoblastic leukemia
    • Neale GA, Pui CH, Mahmoud HH, et al.: Molecular evidence for minimal residual bone marrow disease in children with "isolated" extra-medullary relapse of T-cell acute lymphoblastic leukemia. Leukemia 1994, 8:768-775.
    • (1994) Leukemia , vol.8 , pp. 768-775
    • Neale, G.A.1    Pui, C.H.2    Mahmoud, H.H.3
  • 54
    • 34547782908 scopus 로고
    • Outcomes of children with first marrow relapse: Results from Children's Oncology Group (COG) study AALL01P2
    • Abstract
    • Raetz EA, Borowitz MJ, Devidas M, et al.: Outcomes of children with first marrow relapse: results from Children's Oncology Group (COG) study AALL01P2. Blood (ASH Annual Meeting Abstracts) 2006, 108:530a (Abstract 1871).
    • (1871) Blood (ASH Annual Meeting Abstracts) , vol.108
    • Raetz, E.A.1    Borowitz, M.J.2    Devidas, M.3
  • 55
    • 33746029948 scopus 로고    scopus 로고
    • • Gaynon PS, Harris RE, Altman AJ, et al.: Bone marrow transplantation versus prolonged intensive chemotherapy for children with acute lymphoblastic leukemia and an initial bone marrow relapse within 12 months of the completion of primary therapy: Children's Oncology Group study CCG-1941. J Clin Oncol 2006, 24:3150-3156. In a study flawed by poor adherence to the assigned regimen, Gaynon et al. find similar poor outcomes for early marrow relapse for HST and chemotherapy. Evaluation starts with second complete remission (CR2) in this intent-to-treat analysis.
    • • Gaynon PS, Harris RE, Altman AJ, et al.: Bone marrow transplantation versus prolonged intensive chemotherapy for children with acute lymphoblastic leukemia and an initial bone marrow relapse within 12 months of the completion of primary therapy: Children's Oncology Group study CCG-1941. J Clin Oncol 2006, 24:3150-3156. In a study flawed by poor adherence to the assigned regimen, Gaynon et al. find similar poor outcomes for early marrow relapse for HST and chemotherapy. Evaluation starts with second complete remission (CR2) in this intent-to-treat analysis.
  • 56
    • 33745080964 scopus 로고    scopus 로고
    • • Eapen M, Raetz E, Zhang MJ, et al.: Outcomes after HLA-matched sibling transplantation or chemotherapy in children with B-precursor acute lymphoblastic leukemia in a second remission: a collaborative study of the Children's Oncology Group and the Center for International Blood and Marrow Transplant Research. Blood 2006, 107:4961-4967. Eapen et al. explore registry data and find an advantage for second-remission hematopoietic stem cell transplantation for early (but not later) relapse when compared with a contemporary chemotherapy control.
    • • Eapen M, Raetz E, Zhang MJ, et al.: Outcomes after HLA-matched sibling transplantation or chemotherapy in children with B-precursor acute lymphoblastic leukemia in a second remission: a collaborative study of the Children's Oncology Group and the Center for International Blood and Marrow Transplant Research. Blood 2006, 107:4961-4967. Eapen et al. explore registry data and find an advantage for second-remission hematopoietic stem cell transplantation for early (but not later) relapse when compared with a contemporary chemotherapy control.
  • 57
    • 34247357777 scopus 로고    scopus 로고
    • Pathways through relapses and deaths of children with acute lymphoblastic leukemia: Role of allogeneic stem-cell transplantation in Nordic data
    • Saarinen-Pihkala UM, Heilmann C, Winiarski J, et al.: Pathways through relapses and deaths of children with acute lymphoblastic leukemia: role of allogeneic stem-cell transplantation in Nordic data. J Clin Oncol 2006, 24:5750-5762.
    • (2006) J Clin Oncol , vol.24 , pp. 5750-5762
    • Saarinen-Pihkala, U.M.1    Heilmann, C.2    Winiarski, J.3
  • 58
    • 0033807095 scopus 로고    scopus 로고
    • Comparison of allogeneic transplant versus chemotherapy for relapsed childhood acute lymphoblastic leukaemia in the MRC UKALL R1 trial. MRC Childhood Leukaemia Working Party
    • Harrison G, Richards S, Lawson S, et al.: Comparison of allogeneic transplant versus chemotherapy for relapsed childhood acute lymphoblastic leukaemia in the MRC UKALL R1 trial. MRC Childhood Leukaemia Working Party. Ann Oncol 2000, 11:999-1006.
    • (2000) Ann Oncol , vol.11 , pp. 999-1006
    • Harrison, G.1    Richards, S.2    Lawson, S.3
  • 59
    • 30644480436 scopus 로고    scopus 로고
    • Outcome after first relapse in childhood acute lymphoblastic leukaemia - lessons from the United Kingdom R2 trial
    • Roy A, Cargill A, Love S, et al.: Outcome after first relapse in childhood acute lymphoblastic leukaemia - lessons from the United Kingdom R2 trial. Br J Haematol 2005, 130:67-75.
    • (2005) Br J Haematol , vol.130 , pp. 67-75
    • Roy, A.1    Cargill, A.2    Love, S.3
  • 60
    • 33644834712 scopus 로고    scopus 로고
    • Comparable long-term survival after unrelated and HLA-matched sibling donor hematopoietic stem cell transplantations for acute leukemia in children younger than 18 months
    • Eapen M, Rubinstein P, Zhang MJ, et al.: Comparable long-term survival after unrelated and HLA-matched sibling donor hematopoietic stem cell transplantations for acute leukemia in children younger than 18 months. J Clin Oncol 2006, 24:145-151.
    • (2006) J Clin Oncol , vol.24 , pp. 145-151
    • Eapen, M.1    Rubinstein, P.2    Zhang, M.J.3
  • 61
    • 0035856232 scopus 로고    scopus 로고
    • Prognostic value of minimal residual disease in relapsed childhood acute lymphoblastic leukaemia
    • Eckert C, Biondi A, Seeger K, et al.: Prognostic value of minimal residual disease in relapsed childhood acute lymphoblastic leukaemia. Lancet 2001, 358:1239-1241.
    • (2001) Lancet , vol.358 , pp. 1239-1241
    • Eckert, C.1    Biondi, A.2    Seeger, K.3
  • 62
    • 1542503795 scopus 로고    scopus 로고
    • Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia after first relapse
    • Coustan-Sraith E, Gajjar A, Hijiya N, et al.: Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia after first relapse. Leukemia 2004, 18:499-504.
    • (2004) Leukemia , vol.18 , pp. 499-504
    • Coustan-Sraith, E.1    Gajjar, A.2    Hijiya, N.3
  • 63
    • 0036009606 scopus 로고    scopus 로고
    • Clinical relevance of MRD in children undergoing allogeneic stem cell transplantation for ALL
    • Goulden N, Steward C: Clinical relevance of MRD in children undergoing allogeneic stem cell transplantation for ALL. Best Pract Res Clin Haematol 2002, 15:59-70.
    • (2002) Best Pract Res Clin Haematol , vol.15 , pp. 59-70
    • Goulden, N.1    Steward, C.2
  • 64
    • 0037972752 scopus 로고    scopus 로고
    • Preponderant mitotic activity of nonleukemic cells plays an important role in failures to detect abnormal clone in childhood acute lymphoblastic leukemia
    • Wu SQ, Weinberg KI, Joo WJ, et al.: Preponderant mitotic activity of nonleukemic cells plays an important role in failures to detect abnormal clone in childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol 2003, 25:520-525.
    • (2003) J Pediatr Hematol Oncol , vol.25 , pp. 520-525
    • Wu, S.Q.1    Weinberg, K.I.2    Joo, W.J.3
  • 65
    • 2942563738 scopus 로고    scopus 로고
    • Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia
    • Harrison CJ, Moorman AV, Broadfield ZJ, et al.: Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia. Br J Haematol 2004, 125:552-559.
    • (2004) Br J Haematol , vol.125 , pp. 552-559
    • Harrison, C.J.1    Moorman, A.V.2    Broadfield, Z.J.3
  • 66
    • 19044399684 scopus 로고    scopus 로고
    • Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling
    • Yeoh EJ, Ross ME, Shurtleff SA, et al.: Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 2002, 1:133-143.
    • (2002) Cancer Cell , vol.1 , pp. 133-143
    • Yeoh, E.J.1    Ross, M.E.2    Shurtleff, S.A.3
  • 67
    • 33748702674 scopus 로고    scopus 로고
    • Expression of the outcome predictor in acute leukemia 1 (OPAL1) gene is not an independent prognostic factor in patients treated according to COALL or St Jude protocols
    • Holleman A, den Boer ML, Cheok MH, et al.: Expression of the outcome predictor in acute leukemia 1 (OPAL1) gene is not an independent prognostic factor in patients treated according to COALL or St Jude protocols. Blood 2006, 108:1984-1990.
    • (2006) Blood , vol.108 , pp. 1984-1990
    • Holleman, A.1    den Boer, M.L.2    Cheok, M.H.3
  • 68
    • 34147224008 scopus 로고    scopus 로고
    • •• Mullighan CG, Goorha S, Radtke I, et al.: Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 2007, 446:739-740. Mullighan et al. employ molecular techniques to explore the diversity of DNA gains and losses in various genetic subsets of ALL.
    • •• Mullighan CG, Goorha S, Radtke I, et al.: Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 2007, 446:739-740. Mullighan et al. employ molecular techniques to explore the diversity of DNA gains and losses in various genetic subsets of ALL.
  • 69
    • 0030720796 scopus 로고    scopus 로고
    • Early response to therapy and outcome in childhood acute lymphoblastic leukemia: A review
    • Gaynon PS, Desai AA, Bostrom BC, et al.: Early response to therapy and outcome in childhood acute lymphoblastic leukemia: a review. Cancer 1997, 80:1717-1726.
    • (1997) Cancer , vol.80 , pp. 1717-1726
    • Gaynon, P.S.1    Desai, A.A.2    Bostrom, B.C.3
  • 70
    • 0035102296 scopus 로고    scopus 로고
    • MRD at the end of induction therapy in childhood acute lymphoblastic leukemia: Outcome prediction strongly depends on the therapeutic regimen
    • zur Stadt U, Harms DO, Schluter S, et al.: MRD at the end of induction therapy in childhood acute lymphoblastic leukemia: Outcome prediction strongly depends on the therapeutic regimen. Leukemia 2001, 15:283-285.
    • (2001) Leukemia , vol.15 , pp. 283-285
    • zur Stadt, U.1    Harms, D.O.2    Schluter, S.3
  • 71
    • 0037097740 scopus 로고    scopus 로고
    • Detection of minimal residual disease identifies differences in treatment response between T-ALL and precursor B-ALL
    • Willemse MJ, Seriu T, Hettinger K, et al.: Detection of minimal residual disease identifies differences in treatment response between T-ALL and precursor B-ALL. Blood 2002, 99:4386-4393.
    • (2002) Blood , vol.99 , pp. 4386-4393
    • Willemse, M.J.1    Seriu, T.2    Hettinger, K.3
  • 72
    • 34547741263 scopus 로고    scopus 로고
    • Prognostic significance of minimal residual disease (MRD) in childhood B-precursor ALL and its relation to other risk factors. A Children's Oncology Group (COG) study [abstract]
    • Abstract 219
    • Borowitz MJ, Devidas M, Bowman WP, et al.: Prognostic significance of minimal residual disease (MRD) in childhood B-precursor ALL and its relation to other risk factors. A Children's Oncology Group (COG) study [abstract]. Blood (ASH Annual Meeting Abstracts) 2006, 108:69a (Abstract 219).
    • (2006) Blood (ASH Annual Meeting Abstracts) , vol.108
    • Borowitz, M.J.1    Devidas, M.2    Bowman, W.P.3
  • 73
    • 3042622767 scopus 로고    scopus 로고
    • Rationale and design of Total Therapy Study XV for newly diagnosed childhood acute lymphoblastic leukemia
    • Pui CH, Relling MV, Sandlund JT, et al.: Rationale and design of Total Therapy Study XV for newly diagnosed childhood acute lymphoblastic leukemia. Ann Hematol 2004, 83(suppl 1):S124-S126.
    • (2004) Ann Hematol , vol.83 , Issue.SUPPL. 1
    • Pui, C.H.1    Relling, M.V.2    Sandlund, J.T.3
  • 74
    • 0037085747 scopus 로고    scopus 로고
    • A randomized comparison of native Escherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: A Children's Cancer Group study
    • Avramis VI, Sencer S, Periclou AP, et al.: A randomized comparison of native Escherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: a Children's Cancer Group study. Blood 2002, 99:1986-1994.
    • (2002) Blood , vol.99 , pp. 1986-1994
    • Avramis, V.I.1    Sencer, S.2    Periclou, A.P.3
  • 75
    • 33746594853 scopus 로고    scopus 로고
    • Minimal residual disease (MRD) measurement as a tool to compare the efficacy of chemotherapeutic drug regimens using Escherichia coli-asparaginase or Erwinia-asparaginase in childhood acute lymphoblastic leukemia (ALL)
    • Kwok CS, Kham SK, Ariffin H, et al.: Minimal residual disease (MRD) measurement as a tool to compare the efficacy of chemotherapeutic drug regimens using Escherichia coli-asparaginase or Erwinia-asparaginase in childhood acute lymphoblastic leukemia (ALL). Pediatr Blood Cancer 2006, 47:299-304.
    • (2006) Pediatr Blood Cancer , vol.47 , pp. 299-304
    • Kwok, C.S.1    Kham, S.K.2    Ariffin, H.3
  • 76
    • 34547744573 scopus 로고    scopus 로고
    • Variables affecting kinetics of minimal residual disease clearance in children with lymphoblastic leukaemia; results of the United Kingdom Medical Research Council (UK MRC) Protocols ALL97, ALL97/99, and ALL2003 [abstract]
    • Abstract 86
    • Vora AJ, Richards S, Hancock J, et al.: Variables affecting kinetics of minimal residual disease clearance in children with lymphoblastic leukaemia; results of the United Kingdom Medical Research Council (UK MRC) Protocols ALL97, ALL97/99, and ALL2003 [abstract]. Blood 2005, 106:30a (Abstract 86).
    • (2005) Blood , vol.106
    • Vora, A.J.1    Richards, S.2    Hancock, J.3
  • 77
    • 34547753682 scopus 로고    scopus 로고
    • Changes in delivery of standard chemotherapeutic agents during induction affect early measures of minimal residual disease (MRD): POG 900 for patients with B-precursor low and standard risk ALL [abstract]
    • Abstract 2272
    • Winick N, Borowitz MJ, Devidas M, et al.: Changes in delivery of standard chemotherapeutic agents during induction affect early measures of minimal residual disease (MRD): POG 900 for patients with B-precursor low and standard risk ALL [abstract]. Blood 2006, 108:643a (Abstract 2272).
    • (2006) Blood , vol.108
    • Winick, N.1    Borowitz, M.J.2    Devidas, M.3
  • 78
    • 0035693627 scopus 로고    scopus 로고
    • Comparison of multidimensional flow cytometry with standard morphology for evaluation of early marrow response in pediatric acute lymphoblastic leukemia
    • Meshinchi S, Thomson B, Finn LS, et al.: Comparison of multidimensional flow cytometry with standard morphology for evaluation of early marrow response in pediatric acute lymphoblastic leukemia. J Pediatr Hematol Oncol 2001, 23:585-590.
    • (2001) J Pediatr Hematol Oncol , vol.23 , pp. 585-590
    • Meshinchi, S.1    Thomson, B.2    Finn, L.S.3
  • 79
    • 33846100277 scopus 로고    scopus 로고
    • • Conter V, Valsecchi MG, Silvestri D, et al.: Pulses of vincristine and dexamethasone in addition to intensive chemotherapy for children with intermediate-risk acute lymphoblastic leukaemia: a multicentre randomised trial. Lancet 2007, 369:123-131. Conter et al. demonstrate the redundancy of vincristine and steroid pulses in the context of intensive Berlin-Frankfurt-Münster (BFM)-based therapy. Vincristine and steroid pulses are commonly employed in the United States in this context.
    • • Conter V, Valsecchi MG, Silvestri D, et al.: Pulses of vincristine and dexamethasone in addition to intensive chemotherapy for children with intermediate-risk acute lymphoblastic leukaemia: a multicentre randomised trial. Lancet 2007, 369:123-131. Conter et al. demonstrate the redundancy of vincristine and steroid pulses in the context of intensive Berlin-Frankfurt-Münster (BFM)-based therapy. Vincristine and steroid pulses are commonly employed in the United States in this context.
  • 80
    • 34547733660 scopus 로고    scopus 로고
    • Treatment intensification of traditional BFM therapy with 3 chemotherapy blocks and double delayed intensification (Protocol II) improves outcome in infants with high risk (HR) acute lymphoblastic leukemia (ALL): Results of two consecutive AIEOP studies [abstract]
    • Rizzari C, Valsecchi MG, De Lorenzo P, et al.: Treatment intensification of traditional BFM therapy with 3 chemotherapy blocks and double delayed intensification (Protocol II) improves outcome in infants with high risk (HR) acute lymphoblastic leukemia (ALL): results of two consecutive AIEOP studies [abstract]. Blood 2005:256a.
    • (2005) Blood
    • Rizzari, C.1    Valsecchi, M.G.2    De Lorenzo, P.3
  • 81
    • 33645957325 scopus 로고    scopus 로고
    • Role of treatment intensification in infants with acute lymphoblastic leukemia: Results of two consecutive AIEOP studies
    • Biondi A, Rizzari C, Valsecchi MG, et al.: Role of treatment intensification in infants with acute lymphoblastic leukemia: results of two consecutive AIEOP studies. Haematologica 2006, 91:534-537.
    • (2006) Haematologica , vol.91 , pp. 534-537
    • Biondi, A.1    Rizzari, C.2    Valsecchi, M.G.3
  • 82
    • 70449560042 scopus 로고    scopus 로고
    • Double delayed intensification (DDI) is equivalent to single DI (SDI) in children with National Cancer Institute (NCI) standard-risk acute lymphoblastic leukemia (SR-ALL) treated on Children's Cancer Group (CCG) clinical trial 1991 (CCG-1991) [abstract]
    • Abstract 146
    • Matloub Y, Angiolillo A, Bostrom B, et al.: Double delayed intensification (DDI) is equivalent to single DI (SDI) in children with National Cancer Institute (NCI) standard-risk acute lymphoblastic leukemia (SR-ALL) treated on Children's Cancer Group (CCG) clinical trial 1991 (CCG-1991) [abstract]. Blood 2006, 108:47a (Abstract 146).
    • (2006) Blood , vol.108
    • Matloub, Y.1    Angiolillo, A.2    Bostrom, B.3
  • 83
    • 27244436741 scopus 로고    scopus 로고
    • No advantage of dexamethasone over prednisolone for the outcome of standard- and intermediate-risk childhood acute lymphoblastic leukemia in the Tokyo Children's Cancer Study Group L95-14 protocol
    • Igarashi S, Manabe A, Ohara A, et al.: No advantage of dexamethasone over prednisolone for the outcome of standard- and intermediate-risk childhood acute lymphoblastic leukemia in the Tokyo Children's Cancer Study Group L95-14 protocol. J Clin Oncol 2005, 23:6489-6498.
    • (2005) J Clin Oncol , vol.23 , pp. 6489-6498
    • Igarashi, S.1    Manabe, A.2    Ohara, A.3
  • 84
    • 3543054544 scopus 로고    scopus 로고
    • Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment
    • Holleman A, Cheok MH, den Boer ML, et al.: Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment. N Engl J Med 2004, 351:533-542.
    • (2004) N Engl J Med , vol.351 , pp. 533-542
    • Holleman, A.1    Cheok, M.H.2    den Boer, M.L.3
  • 85
    • 20244377046 scopus 로고    scopus 로고
    • Identification of genes associated with chemotherapy cross-resistance and treatment response in childhood acute lymphoblastic leukemia
    • Lugthart S, Cheok MH, den Boer ML, et al.: Identification of genes associated with chemotherapy cross-resistance and treatment response in childhood acute lymphoblastic leukemia. Cancer Cell 2005, 7:375-386.
    • (2005) Cancer Cell , vol.7 , pp. 375-386
    • Lugthart, S.1    Cheok, M.H.2    den Boer, M.L.3
  • 86
    • 33746649033 scopus 로고    scopus 로고
    • Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: Prognostic significance of CASP8AP2
    • Flotho C, Coustan-Smith E, Pei D, et al.: Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2. Blood 2006, 108:1050-1057.
    • (2006) Blood , vol.108 , pp. 1050-1057
    • Flotho, C.1    Coustan-Smith, E.2    Pei, D.3
  • 87
    • 30444446961 scopus 로고    scopus 로고
    • The expression of 70 apoptosis genes in relation to lineage, genetic subtype, cellular drug resistance, and outcome in childhood acute lymphoblastic leukemia
    • Holleman A, den Boer ML, de Menezes RX, et al.: The expression of 70 apoptosis genes in relation to lineage, genetic subtype, cellular drug resistance, and outcome in childhood acute lymphoblastic leukemia. Blood 2006, 107:769-776.
    • (2006) Blood , vol.107 , pp. 769-776
    • Holleman, A.1    den Boer, M.L.2    de Menezes, R.X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.