Isolation of two bioactive ent-kauranoids from the leaves of Isodon xerophilus

Journal of Agricultural and Food Chemistry

Volumn 55, Issue 15, 2007, Pages 6039-6043

  Weng, Zhi Ying ^a,b,c   Huang, Sheng Xiong ^a,b   Li, Ma Lin ^c   Zeng, Yue Qin ^d   Han, Quan Bin ^a   Rios, Jose Luis ^d   Sun, Han Dong ^a  

^a KUNMING INSTITUTE OF BOTANY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c KUNMING MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Anti inflammation; Cytotoxicity; ent kaurene diterpenoid; Herbal tea; Isodon xerophilus

Indexed keywords

ANTINEOPLASTIC AGENT; KAURANE DERIVATIVE; UNCLASSIFIED DRUG; XEROPHINOID A; XEROPHINOID B;

ANIMAL; ARTICLE; CELL DEATH; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; HUMAN; ISODON; ISOLATION AND PURIFICATION; PLANT LEAF; RAT; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL DEATH; CELL LINE, TUMOR; DITERPENES, KAURANE; HUMANS; ISODON; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PLANT LEAVES; RATS;

ISODON; ISODON XEROPHILUS;

EID: 34547770931     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf070734w     Document Type: Article

References (18)

1. Bremner, P.; Heinrich, M. Natural products as targeted modulators of the nuclear factor-κB pathway. J. Pharm. Pharmacol. 2002, 54, 453-472.
2. Sun, H. D.; Huang, S. X.; Han, Q. B. Diterpenoids from Isodon species and their biological activities. Nat. Prod. Rep. 2006, 23, 673-698.
3. Hou, A. J.; Li, M. L.; Jiang, B.; Lin, Z. W.; Ji, S. Y.; Zhou, Y. P.; Sun, H. D. New 7,20:14,20-diepoxy ent-kauranoids from Isodon xerophilus. J. Nat. Prod. 2000, 63, 599-601.
4. Hou, A. J.; Yang, H.; Jiang, B.; Zhao, Q. S.; Liu, Y. Z.; Lin, Z. W.; Sun, H. D. Two new ent-kaurane diterpenoids from Isodon xerophilus. Chin. Chem. Lett. 2000, 11, 795-798.
5. Hou, A. J.; Zhao, Q. S.; Li, M. L.; Jiang, B.; Lin, Z. W.; Sun, H. D.; Zhou, Y. P.; Lu, Y.; Zheng, Q. T. Cytotoxic 7,20-epoxy ent-kauranoids from Isodon xerophilus. Phytochemistry 2001, 58, 179-183.
6. Li, S. H.; Niu, X. M.; Peng, L. Y.; Zhang, H. J.; Yao, P.; Sun, H. D. ent-Kaurane diterpenoids from the leaves of Isodon xerophilus. Planta Med. 2002, 68, 946-948.
7. Niu, X. M.; Li, S. H.; Na, Z.; Lin, Z. W.; Sun, H. D. Two novel ent-abietane diterpenoids from Isodon xerophilus. Helv. Chim. Acta 2004, 87, 1951-1957.
8. Escandell, J. M.; Recio, M. C.; Máñez, S.; Giner, R. M.; Cerdá-Nicolás, M.; Ríos, J. L. Dihydrocucurbitacin B, isolated from Cayaponia tayuya, reduces damage in adjuvant-induced arthritis. Eur. J. Pharmacol. 2006, 532, 145-154.
9. Kuo, Y. C.; Weng, S. C.; Chou, C. J.; Chang, T. T.; Tsai, W. J. Activation and proliferation signals in primary human T lymphocytes inhibited by ergosterol peroxide isolated from Cordyceps cicadae. Br. J. Pharmacol. 2003, 40, 895-906.
10. Takeda, Y.; Takeda, K. I.; Fujita, T.; Sun, H. D.; Minami, Y. Rabdoternins D-G, ent-7β-20-epoxykaurenes from Rabdosia ternifolia. Phytochemistry 1994, 35, 1513-1516.
11. Cheng, P. Y.; Lin, Y. L.; Xu, G. Y. New diterpenoids of Rabdosia macrocalyx: the structure of macrocalin A and macrocalin B. Acta Pharm. Sin. 1984, 19, 593-598.
12. Hou, A. J.; Jiang, B.; Yang, H.; Zhao, Q. S.; Lin, Z. W.; Sun, H. D. Three new ent-kaurane diterpenoids from Isodon xerophilus. Acta Bot. Yunnanica 2000, 22, 197-200.
13. Abbaskhan, A.; Choudhary, M. I.; Tsuda, Y.; Parvez, M.; Attaur-Rahman; Shaheen, F.; Parween, Z.; Tareen, R. B.; Zaidi, M. A. A new diepoxy-ent-kauranoid, rugosinin, from Isodon rugosus. Planta Med. 2003, 69, 94-96.
14. Sun, H. D.; Chao, J. H.; Lin, Z. W.; Marunaka, T.; Minami, Y.; Fujita, T. The structure of rubescensin C: a new minor diterpenoid isolated from Rabdosia rubescens. Chem. Pharm. Bull. 1982, 50, 341-343.
15. Sun, H. D.; Zhou, Q. Z.; Fujita, T.; Takeda, Y.; Minami, Y.; Marunaka, T.; Lin, Z. W.; Shen, X. Y. Rubescensin D, a diterpenoid from Rabdosia rubescens. Phytochemistry 1992, 31, 1418-1419.
16. Suzuki, I.; Kondoh, M.; Harada, M.; Koizumi, N.; Fujii, M.; Nagashima, F.; Asakawa, Y.; Watanabe, Y. An ent-kaurene diterpene enhances apoptosis induced by tumor necrosis factor in human leukemia cells. Planta Med. 2004, 70, 723-727.
17. Hwang, B. Y.; Lee, J. H.; Koo, T. H.; Kim, H. S.; Hong, Y. S.; Ro, J. S.; Lee, K. S.; Lee, J. J. Kaurane diterpenes from Isodon japonicus inhibit nitric oxide and prostaglandin E2 production and NF-kappaB activation in LPS-stimulated macrophage RAW264.7 cells. Planta Med. 2001, 67, 406-410.
18. Lee, J. H.; Koo, T. H.; Hwang, B. Y.; Lee, J. Kaurane diterpene, kamebakaurin, inhibits NF-κ B by directly targeting the DNA-binding activity of p50 and blocks the expression of antiapoptotic NF-κ B target genes. J. Biol. Chem. 2002, 277, 18411-18420.