Effects of ifenprodil on voltage-gated tetrodotoxin-resistant Na + channels in rat sensory neurons

European Journal of Anaesthesiology

Volumn 24, Issue 9, 2007, Pages 782-788

  Tanahashi, S ^a   Iida, H ^a   Oda, A ^a   Osawa, Y ^a   Uchida, M ^a   Dohi, S ^a  

^a GIFU UNIVERSITY   (Japan)

Author keywords

Analgesics, mechanism of action; Ketamine; Rat; Receptors N methyl D aspartate, antagonists, ifenprodil; Sodium channels, tetrodotoxin resistant

Indexed keywords

IFENPRODIL; KETAMINE; LIDOCAINE; SODIUM CHANNEL; TETRODOTOXIN; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; HYPERPOLARIZATION; MALE; NERVE CELL MEMBRANE; NOCICEPTION; NONHUMAN; PATCH CLAMP; RAT; SENSORY NERVE CELL; SPINAL GANGLION;

ADRENERGIC ALPHA-ANTAGONISTS; ANALGESICS; ANESTHETICS, LOCAL; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GANGLIA, SPINAL; ION CHANNEL GATING; KETAMINE; LIDOCAINE; MALE; MEMBRANE POTENTIALS; NEURONS, AFFERENT; NOCICEPTORS; PATCH-CLAMP TECHNIQUES; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS; TETRODOTOXIN;

EID: 34547733595     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1017/S0265021507000440     Document Type: Article

References (21)

1. Chizh BA, Headley PM, Tzschentke TM. NMDA receptor antagonists as analgesics: focus on the NR2B subtype. T Pharmaco Sci 2001; 22: 636-642.
2. Ren K, Williams GM, Hylden JL et al. The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats. Eur J Pharmacol 1992; 219: 235-243.
3. Iida H, Dohi S, Tanahashi T et al. Spinal conduction block by intrathecal ketamine in dogs. Anesth Analg 1997; 85(1): 106-110.
4. Bai L, Zhao ZQ. Ketamine induced peripheral analgesia in rats. Acta Pharmacol Sinica 1997; 18: 377-379.
5. Carron C, Jullien A, Bucher B. Synthesis and pharmacological properties of a series of 2-piperidino alkanol derivatives. Arzneimittelforschung 1971; 21(12): 1992-1998.
6. Zhi-Shang Z, Zhi-Qi Z. Ketamine blockage of both tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels of rat dorsal root ganglion neurons. Brain Res Bull 2000; 52: 427-433.
7. Quasthoff S, Grosskreutz J, Schroder JM et al. Calcium potentials and tetrodotoxin-resistant sodium potentials in unmyelinated C fibers of biopsied human sural nerve. Neuroscience 1995; 69: 955-965.
8. + channels in rat dorsal root ganglia. J Physiol (Lond.) 1993; 466: 9-37.
9. + channels in rat dorsal root ganglion neurons. Anesth Analg 2000; 91: 1213-1220.
10. Song JH, Huang CS, Nagata K et al. Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. J Pharmacol Exp Ther 1997; 282: 707-714.
11. Akopian AN, Souslova V, England S et al. The tetrodotoxin- resistant sodium channel SNS has a specialized function in pain pathways. Nature Neurosci 1999; 2: 541-548.
12. Bean BP, Cohen CJ, Tsien RW. Lidocaine block of cardiac sodium channels. J Gen Physiol 1983; 81: 613-642.
13. Sanguinetti MC, Kass RS. Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists. Circ Res 1984; 55: 336-348.
14. Kim YS, Shin YK, Lee C, Song J. Block of sodium currents in rat dorsal root ganglion neurons by diphenhydramine. Brain Res 2000; 881: 190-198.
15. + current in nociceptors. Proc Natl Acad Sci USA 1996; 93: 1108-1112.
16. + currents in rat sensory neurons. Anesthesiology 2001; 94: 137-144.
17. Catterall WA. From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron 2000; 26: 13-25.
18. Wildsmith JA, Brown DT, Paul D, Johnson S. Structure-activity relationships in differential nerve block at high and low frequency stimulation. Br J Anaesth 1989; 63: 444-452.
19. Orser BA, Pennefather PS, MacDonald JF. Multiple mechanisms of ketamine blockade of N-methyl-D-aspartate receptors. Anesthesiology 1997; 86: 903-917.
20. Avenet P, Leonardon J, Besnard F et al. Antagonist properties of the stereoisomers of ifenprodil at NR1A/NR2A and NR1A/NR2B subtypes of the NMDA receptor expressed in Xenopus oocytes. Eur J Pharmacol 1996; 296: 209-213.
21. Porreca F, Lai J, Bian D et al. A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain. Proc Natl Acad Sci USA 1999; 96: 7640-7644.