Selective estrogen receptor modulator inhibits osteocyte apoptosis during abrupt estrogen withdrawal: Implications for bone quality maintenance

Calcified Tissue International

Volumn 81, Issue 2, 2007, Pages 139-144

  Huber, C ^a   Collishaw, S ^a   Mosley, J R ^a   Reeve, J ^b   Noble, B S ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

17 Estradiol; Apoptosis; Osteocyte; Selective estrogen receptor modulator

Indexed keywords

6 HYDROXY 2 (4 HYDROXYPHENYL) 3 [4 [2 (1 PYRROLIDINYL)ETHOXY]BENZOYL]BENZO[B]THIOPHENE; ESTRADIOL; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE; CONTROLLED STUDY; DNA NICK TRANSLATION; DRUG EFFECT; DRUG MECHANISM; FEMALE; NONHUMAN; OSTEOCYTE; OVARIECTOMY; PRIORITY JOURNAL; RADIUS; RAT; REGULATORY MECHANISM; ULNA;

ANIMALS; APOPTOSIS; BONE AND BONES; BONE DENSITY; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGENS; FEMALE; HUMANS; OSTEOCYTES; OSTEOPOROSIS, POSTMENOPAUSAL; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; SELECTIVE ESTROGEN RECEPTOR MODULATORS; THIOPHENES; TREATMENT OUTCOME;

EID: 34547732518     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-007-9049-6     Document Type: Article

References (26)

1. Lanyon LE (1993) Osteocytes, strain detection, bone modeling and remodeling. Calcif Tissue Int 53(suppl 1):S102-S107
2. Kamijou T, Nakajima T, Ozawa H (1994) Effects of osteocytes on osteoinduction in the autogenous rib graft in the rat mandible. Bone 15:629-637
3. Marrotti G, Remaggi F, Tartari F (1998) Morphometric investigation on osteocytes on human auditory ossicles. Ann Anat 180:449-453
4. Power J, Noble BS, Loveridge N, Bell KL, Rushton N, Reeve J (2001) Osteocyte lacunar occupancy in the femoral neck cortex: an association with cortical remodelling in hip fracture case and controls. Calcif Tissue Int 69:13-19
5. Qiu S, Rao DS, Palnitkar S, Parfitt AM (2002) Relationship between osteocyte density and bone formation rate in human cancellous bone. Bone 31:709-711
6. Hernandez CJ, Majeska RJ, Schaffler MB (2004) Osteocyte density in woven bone. Bone 35:1095-1099
7. Burr DB, Martin RB, Schaffler MB, Radin EL (1985) Bone remodeling in response to in vivo fatigue microdamage. J Biomech 18:189-200
8. Parfitt AM (2001) The bone remodeling compartment: a circulatory function for bone lining cells. J Bone Miner Res 16:1583-1585
9. Noble BS, Peet N, Stevens HY, Brabbs A, Mosley JR, Reilly GC, Reeve J, Skerry TM, Lanyon LE (2003) Mechanical loading: biphasic osteocyte survival and targeting of osteoclasts for bone destruction in rat cortical bone. Am J Physiol Cell Physiol 284:C934-C943
10. Allbright F, Smith PH, Richardson AM (1941) Postmenopausal osteoporosis. JAMA 116:2465-2474
11. Wronski TJ, Dann LM, Scott KS, Cintron M (1989) Long term effects of ovariectomy and aging on the rat skeleton. Calcif Tissue Int 45:360-366
12. Kalu DN (1991) The ovariectomized rat model of postmenopausal bone loss. Bone Miner 15:175-191
13. Tomkinson A, Gevers EF, Wit JM, Reeve J, Noble BS (1998) The role of estrogen in the control of rat osteocyte apoptosis. J Bone Miner Res 13:1243-1250
14. Tomkinson A, Reeve J, Shaw RW, Noble BS (1997) The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone. J Clin Endocrinol Metab 82:3128-3135
15. Kauffman RF, Bryant HU (1995) Effective therapeutic management of the postmenopausal state will be a cornerstone in strategies for preserving or improving women's health in the 21st century. Selective estrogen receptor modulators. Drug News Perspect 8:531-539
16. Delmas PD, Bjarnason NH, Mitlak BH, Ravoux AC, Shah AS, Huster WJ, Draper M, Christiansen C (1997) Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women. N Engl J Med 337:1641-1647
17. Curiel MD, Calero JA, Guerrero R, Gala J, Gazapo R, de la Piedra C (1998) Effects of LY-117018 HCl on bone remodeling and mineral density in the oophorectomized rat. Am J Obstet Gynecol 178:320-325
18. Li X, Takahashi M, Kushida K, Inoue T (1998) The preventive and interventional effects of raloxifene analog (LY117018 HCL) on osteopenia in ovariectomized rats. J Bone Miner Res 13:1005-1010
19. Hodsman AB, Drost D, Fraher LJ, Holdsworth D, Thornton M, Hock J, Bryant H, Watson PH (1999) The addition of a raloxifene analog (LY117018) allows for reduced PTH(1-34) dosing during reversal of osteopenia in ovariectomized rats. J Bone Miner Res 14:675-679
20. Bowman AR, Sass DA, Marshall I, Ma YF, Liang H, Jee WS, Epstein S (1996) Raloxifene analog (LY117018 HCL) ameliorates cyclosporin A-induced osteopenia in oophorectomized rats. J Bone Miner Res 11:1191-1198
21. Noble BS, Stevens H, Loveridge N, Reeve J (1997) Identification of apoptotic changes in osteocytes in normal and pathological human bone. Bone 20:273-282
22. Noble BS, Stevens HY (2003) Techniques for the study of apoptosis in bone. In: Helfrich MH, Ralston SH (eds), Methods in Molecular Medicine: Bone Research Protocols. Humana Press, Totowa, NJ, pp 225-236
23. Kousteni S, Chen JR, Bellido T, Han L, Ali AA, O'Brien CA, Plotkin L, Fu Q, Mancino AT, Wen Y, Vertino AM, Powers CC, Stewart SA, Ebert R, Parfitt AM, Weinstein RS, Jilka RL, Manolagas SC (2002) Reversal of bone loss in mice by nongenotropic signaling of sex steroids. Science 298:843-846
24. Kousteni S, Bellido T, Plotkin LI, O'Brien CA, Bodenner DL, Han L, Han K, DiGregorio GB, Katzenellenbogen JA, Katzenellenbogen BS, Roberson PK, Weinstein RS, Jilka RL, Manolagas SC (2001) Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell 104:719-730
25. Mann V, Huber C, Kogianni G, Collins F, Noble BS (2007) The antioxidant effect of estrogen and SERMs in the inhibition of osteocyte apoptosis in vitro. Bone 40:674-684
26. Poole KE, Van Bezooijen RL, Loveridge N, Hamersma H, Papapoulos SC, Lowik CW, Reeve J (2005) Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation. FASEB J 19:1842-1844